A5066007637- Diet and metabolism studies
- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Lipoproteins and Cardiovascular Health
- Cytokine Signaling Pathways and Interactions
- Muscle metabolism and nutrition
- Atherosclerosis and Cardiovascular Diseases
- Fatty Acid Research and Health
- Sports injuries and prevention
- Pharmaceutical Economics and Policy
- Neuroinflammation and Neurodegeneration Mechanisms
- Exercise and Physiological Responses
- Gut microbiota and health
- Neurological Disease Mechanisms and Treatments
- Electron Spin Resonance Studies
- Sphingolipid Metabolism and Signaling
- Cardiovascular Disease and Adiposity
- Ultrasound and Hyperthermia Applications
- Metabolism and Genetic Disorders
- Heart Rate Variability and Autonomic Control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Psoriasis: Treatment and Pathogenesis
- Ginkgo biloba and Cashew Applications
Biomedical Research Center of the Slovak Academy of Sciences
2018-2024
National Institute of Rheumatic Diseases
2023
Slovak Academy of Sciences
2020-2022
Inflammatory cytokines contribute to proatherogenic changes in lipid metabolism by reduction of HDL-cholesterol (HDL-C) levels, impairment its antiinflammatory and antioxidant functions. Therefore, the protective actions HDL-C can be limited chronic inflammatory diseases such as multiple sclerosis (MS). The aim this study was assess association between lipoprotein subfractions status early stages sclerosis.Polyacrylamide gel electrophoresis Lipoprint© System used for profile analysis 19...
Abstract Background Physical exercise has favorable effects on the structure of gut microbiota and metabolite production in sedentary subjects. However, little is known whether adjustments an athletic program impact overall changes microbiome high-level athletes. We therefore characterized fecal serum metabolites response to a 7-week, high-intensity training consumption probiotic Bryndza cheese. Methods Fecal blood samples logs were collected from young competitive male ( n = 17) female 7)...
Abstract Objectives. Sedentary lifestyle increasingly observed in the population contributes to incremental incidence of obesity, cardiovascular diseases, mental disorders, type 2 diabetes, hyper-tension, dyslipidemia, and others. Physical inactivity together with an imbalance caloric intake expenditure leads a loss muscle mass, reduced insulin sensitivity, accumulation visceral fat. Organokines (adipokines, myokines, hepatokines, etc.) serve organism for inter-organ communication. However,...
Increased metabolic and cardiovascular morbidity has been reported in multiple sclerosis (MS) patients. Previously, we have found decreased insulin sensitivity hyperinsulinemia a group of newly diagnosed MS We hypothesize that these features may be associated with an altered lipid profile low, intermediate, or high density lipoprotein (LDL, IDL, HDL) subclasses accelerating atherosclerosis thus contributing to the risk increase patients.In 19 untreated patients previously resistance matched...
Introduction: Epidemiological studies have suggested an increased vascular risk in patients with multiple sclerosis (MS). There is increasing evidence of the beneficial effects GLP-1 agonists (GLP-1a) preventing complications and slowing progression neurodegeneration. Our objective was to explore changes endothelial function MS after 12 months GLP-1a therapy. We also explored role lipoprotein subfractions antioxidant capacity plasma. Methods: were enrolled a prospective, unicentric study....
Alkaptonuria (AKU, OMIM, No. 203500) is a rare, slow-progressing, irreversible, multisystemic disease resulting from deficiency of the homogentisate 1,2-dioxygenase enzyme, which leads to accumulation homogentisic acid (HGA) and subsequent deposition as pigment in connective tissues called ochronosis. As result, severe arthropathy large joints spondyloarthropathy with frequent fractures, ligament ruptures, osteoporosis develops AKU patients. Since 2020, first-time treatment nitisinone has...
Proproteínkonvertáza subtilizín kexín typu 9 (PCSK9) zohráva kľúčovú úlohu v regulácii expresie LDL receptorov (LDLR). Klinické štúdie s monoklonálnymi protilátkami proti cirkulujúcemu PCSK9 (anti-PCSK9 MAbs) preukázali nielen potentný efekt na redukciu LDL-cholesterolu (až do asi 60 %), ale aj rizika veľkých kardiovaskulárnych príhod. Avšak mendelovské randomizačné ukázali, že nositelia loss-of-function variant génu pre majú okrem nižších hladín zvýšené riziko rozvoja diabetes mellitus 2....
Autonomic nervous system (ANS) disorders are common in multiple sclerosis (MS). Previous studies showed differences insulin resistance (IR) and lipoprotein levels MS subjects compared to controls. Lipolysis caused by increased sympathetic activity could be one of the possible linking mechanisms leading dyslipidemia MS. Our study aimed evaluate ANS context glucose lipid metabolism people with We prospectively measured short-term heart rate variability (HRV), fasting concentrations, calculated...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
<h3>Background</h3> Interleukin 35 (IL-35) is a recently identified member of the IL-12 family cytokines and represents novel target for therapies autoimmune, inflammatory, infectious diseases, including rheumatoid arthritis (RA).<sup>Choi et al. 2015</sup> IL-35 heterodimer consisting EBV-induced gene 3 (EBI3) IL-12α chain p35 (Nakano 2015). In contrast to other cytokine members, appears have anti-inflammatory immunosuppressive properties mediated by induction regulatory T B cells; (Choi...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Background Central obesity and dyslipidemia are a cardinal features of the metabolic syndrome represents increased cardiometabolic risk. It has been shown that weight loss is capable to improve insulin sensitivity lipid parameters. The aim our study was analyze effect weight-lowering program (diet physical activity) on LDL- HDL-cholesterol subfractions risk factors (waist circumference, blood pressure, sensitivity, fitness). Methods We studied 2 groups obese subjects, group A...