A5000990368- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Advanced Glycation End Products research
- Acute Ischemic Stroke Management
- Diet, Metabolism, and Disease
- Biochemical effects in animals
- Drug-Induced Hepatotoxicity and Protection
- Alcoholism and Thiamine Deficiency
- Vitamin C and Antioxidants Research
- Bacterial Infections and Vaccines
- Tryptophan and brain disorders
- Metabolism and Genetic Disorders
- Sports Performance and Training
- Infectious Diseases and Tuberculosis
- Cancer, Lipids, and Metabolism
- Genetics and Physical Performance
- Medical and Biological Ozone Research
- Biochemical Acid Research Studies
- Chemical Reactions and Isotopes
- Cardiac Arrest and Resuscitation
- Alzheimer's disease research and treatments
- Sirtuins and Resveratrol in Medicine
- Sulfur Compounds in Biology
- Cardiac Ischemia and Reperfusion
Dnipropetrovsk State Medical Academy
2018-2021
Ministry of Health
2019-2020
Introduction: Diabetes mellitus is associated with the development of carbonyl-oxidative stress (COS) and an increased risk a cerebral hemorrhage. Vitamin D3 considered additional drug to have impact on COS proteolysis in extracellular matrix. Objective: The study aimed evaluate COS-markers matrix metallo-proteinases MMP2/MMP9 activity after acute intracerebral hemorrhage (ICH) rats experimental type 2 diabetes (Т2DM) compared metformin (Met). Methods: T2DM was induced via intraperitoneal...
The aim of this study was to the effect metformin (Met) on formation conditional passive avoidance skills, markers neurogenesis and oxidative stress in brain rats with acute intracerebral hemorrhage (ICH) setting streptozotocin-nicotinamide-induced diabetes. Type 2 diabetes mellitus (T2DM) induced via intraperitoneal injection streptozotocin (STZ) nicotinamide (NA), ICH – by microinjection bacterial collagenase into striatum. Rats were randomly divided four groups: 1 intact animals (n=8),...
Type 2 diabetes mellitus (T2DM) is associated with a higher incidence of hemorrhagic stroke in severe form. The aim this study was to estimate the markers oxidative stress and neuroinflammation brain rats acute intracerebral hemorrhage (ICH) T2DM after treatment edaravone. induced by single intraperitoneal injection nicotinamide/streptozotocin, ICH – stereotactic microinjection bacterial collagenase. Rats were randomized into four groups: 1 intact control; T2DM; 3 T2DM+ICH; 4...
Stroke, especially hemorrhagic form, is one of the most serious comorbidity disease diabetes mellitus, often associated with high mortality, particularly in type 2 DM (T2DM). Therefore, it relevant search for drugs a metabolically justified protective effect. Edaravone (Eda) widely used treating ischemic stroke but its biochemical effects intracerebral hemorrhage (ICH) T2DM not still confirmed. The aim study was to assess impact Eda on markers oxidative modification proteins (OMP), such as...
Diabetes mellitus is characterized by numerous pathological changes in the body. Under conditions of diabetes, hyperglycemic intoxication organism rapidly develops, which turn leads to an increase oxidative stress with subsequent disturbance anatomical and functional integrity components organisms. Today, search for substances that would contribute multi-vectoral effect on negative consequences diabetes actively being pursued. Melatonin one such substances. In this work, we studied melatonin...
The aim of this study was to determine the correlations between markers oxidant-antioxidant stress in blood experimental animals, as well content bilirubin and activity enzymes obstructive jaundice. Studies were conducted on 84 adult male Wistar rats (180-230 g). Animals divided into 4 groups: intact (n = 12), control 24), L-lysine escinate (0,5 mg/kg, n 24) glutargin (40 24). isolation ligation common bile duct below confluence carried out under general anesthesia. test preparations...
Clinical evidence suggests that type 2 diabetes mellitus can increase the risk of intracerebral hemorrhage and provocation neurodegeneration. This study was aimed at evaluating biomarkers glycemic control, lipid profile, oxidative modification proteins, as well functional state endothelium in Wistar rats with complicated by hemorrhage. Experimental induced intraperitoneal injection streptozotocin (65 mg/kg) nicotinamide (230 mg/kg). The microinjection sterile saline containing 0.2 IU...
Chronic hyperglycemia, insulin resistance, endothelial dysfunction, and disturbance of the integrity blood-brain barrier are considered as strategically important links in development cognitive deficits diabetic encephalopathy. Taking this into account, one modern trends optimization treatment impairments induced by prolonged hyperglycemia is co-administration agents with antihyperglycemic nootropic activity, particular, metformin piracetam. It has been shown that under conditions...
This comparative research is aimed to study the effect of perindopril and metformin on levels biochemical markers endothelial dysfunction in rats with type 2 diabetes mellitus (T2DM) complicated by a brain hemorrhage. The was carried out 30 white male Wistar rats. T2DM simulated single intraperitoneal injection nicotinamide streptozotocin (NA/STZ). Intracerebral hemorrhage (ICH) induced microinjection 1 μL bacterial collagenase 0.2 IU/μL into striatum 60th day experiment. Animals were...
Hyperproduction of highly active carbonyl compounds and reactive oxygen species initiates the development oxidative stress in various pathological conditions protein carbonylation is considered to be one key factors progression diabetes mellitus associated complications. This comparative research aimed study effect metformin rosuvastatin on levels biochemical markers stress, glycemic control, lipid profile rats with type 2 (T2DM) complicated by a brain hemorrhage.T2DM was simulated single...
<p>In this study we examined the activity of antioxidant enzymes and gelatinases in rats with epinephrine-induced<br />myocardial ischemia impact corvitin (C) doxycycline (D) on these indicators. The administration<br />of epinephrine (0.2 mg/100 g) for 10 days leads to an increase lipid peroxidation elevated of<br />antioxidant blood heart experimental animals. Under application C and<br />D was reduced, especially SOD gelatinases. Our data suggest that D<br...
Background. Investigation of metabolic mechanisms cerebrovascular and cognitive disorders in patients with syndrome are still relevant. According to different data Resveratrol is a powerful antioxidant that improves insulin sensitivity, prevents decline mental functions, inhibits oxidative stress, etc. Objective. To identify morphological changes the neocortex rats experimental fructose-induced conditions course administration Resveratrol. Methods. The study included 24 white weighing...
Еволюція лікарських засобів у XXI столітті ознаменувалася істотним підвищенням вимог до їх ефективності та безпеки. При цьому досить жорстким критеріям безпеки відповідає вельми обмежений спектр препаратів, зокрема представники популяції ноотропів, що мають унікальні клініко-фармакологічні можливості. У статті запропоновані варіанти оптимізації ноотропної терапії препаратом Олатропіл, представляє собою поєднання в одній лікарській формі двох «істинних» ноотропів — аміналону (125 мг) і...
Topicality. The main disadvantage of the first-line anti-TB drugs isoniazid and rifampicin is their ability to cause drug-induced liver injury. At same time, in addition hepatotoxic, 12-24 % cases are neurological disorders. consequence these processes a disturbance synaptic plasticity, learning memory. In addition, significant factor development disorders may be an imbalance intestinal microflora. One possible options at eliminating or attenuating manifestations cognitive deficiency various...
Introduction. Recently, more attention is being paid to the drug-induced liver injury (DILI) as a consequence of tuberculos treatment and need for new medicine emphasized. The use isoniazid rifampicin has potentiating effect, which increases risk substancial damage. In turn, systemic accumulation toxic metabolites leads negative changes in various organs, including brain. It causes an imbalance biochemical neurophysiological processes brain, ultimately giving onset development hepatic...