A5101523143- Spinal Cord Injury Research
- Immune cells in cancer
- Nerve injury and regeneration
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Flavonoids in Medical Research
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Neurological Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Estrogen and related hormone effects
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Pregnancy-related medical research
- Neurogenesis and neuroplasticity mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Mesenchymal stem cell research
- Venous Thromboembolism Diagnosis and Management
- Glaucoma and retinal disorders
- Chronic Lymphocytic Leukemia Research
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Inflammatory mediators and NSAID effects
Hebei Medical University
2013-2023
Third Hospital of Hebei Medical University
2017-2023
The University of Texas Health Science Center at Houston
2013-2017
The transplantation of neural stem/progenitor cells is a promising therapeutic strategy for spinal cord injury (SCI).In this study, we tested whether combination neurotrophic factors and glial-restricted precursor (GRPs)-derived astrocytes (GDAs) could decrease the promote functional recovery after SCI.We developed protocol to quickly produce sufficiently large, homogenous population young from GRPs, earliest arising progenitor cell restricted generation glia.GDAs expressed axonal...
Baicalin had neuroprotective effects on inhibiting neuronal cell apoptosis induced by spinal cord ischemic injury. This study aimed to explore the protective of rats with injury (SCI) and its mechanism action. The recovery nerve function in was evaluated Basso, Beattie, Bresnahan (BBB) score combine behavioral (CBS). expressions cytokines tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), IL-6 were detected enzyme-linked immunosorbent assay method. Expressions inflammation-related...
BACKGROUND Rheumatoid arthritis model (CIA) rats were treated by tail vein injection of IL-10-modified bone marrow mesenchymal stem cells (BMSCs) to investigate its feasibility and intrinsic molecular mechanism. MATERIAL AND METHODS The CIA rat was established induction type II collagen, BMSCs transfecting with adenovirus. used treat the rats. therapeutic effect evaluated measuring changes in body weight, ankle swelling, forced swimming time, as well observation synovial hyperplasia...
Background: Chemokines play a key role in post-traumatic inflammation and secondary injury after spinal cord (SCI).CCL28, the chemokine CC-chemokine ligand 28, is involved epithelial mucosal immunity.However, whether CCL28 participates physiopathologic processes SCI remains unclear. Results: upregulated SCI.In addition, neutralizing antibodies against IL-1β or TNF-α, treatment of ML120B, selective inhibitor IKK-β, remarkably decrease upregulation, suggesting that upregulation relies on NF-κB...
Background/Aims: Osteoarthritis (OA) is the most common joint disease. Recently, a novel variant near nuclear receptor coactivator 3 (NCOA3) has been identified in association with greater risk of developing OA. However, how NCOA3 regulated chondrocytes and involved OA pathogenesis remain elusive. Methods: The expression DNA methylation knee cartilage vitro dedifferentiated or without rs6094710 SNP were analyzed by qRT-PCR, immunoblotting, methylation-specific PCR bisulfite sequencing. was...
Spinal cord injury (SCI) is a devastating disease insulting neurological system, and it could be further exacerbated by overwhelming inflammatory responses, where macrophages play central role. Depending on their heterogeneous phenotypes, contribute intricately to SCI's pathological processes functional recovery. Although stimuli like interferons cytokines are known regulate phonotypical transition, remains elusive which epigenetic programs engage complete phenotype shift. We report here...
PMMA bone cement leads to the development of local thrombi. Our study found that ES-PMMA cement, a novel material, can reduce thrombosis. We used simple and reproducible animal model confirm reduction in thrombosis preliminarily explored associated molecular mechanism.New Zealand rabbits, which were using extracorporeal carotid artery shunts, divided into following three groups, with 10 rabbits each group: sham group, group group. Four hours after modelling, experimental samples collected,...
The implantation of PMMA bone cement results in an immune response and the release particles causes inflammatory cascade. Our study discovered that ES-PMMA can induce M2 polarization macrophages, which has anti-inflammatory immunomodulatory effect. We also delved into molecular mechanisms underlie this process.In study, we designed prepared samples cement. These included samples, were implanted back muscles rats. At 3, 7, 14 days after operation, removed a small amount surrounding tissue....
The study was designed to reveal the genetic relationship of lymphotoxin-α (LTA) polymorphisms with risk ankylosing spondylitis (AS) in Chinese Han population. LTA were genotyped by polymerase chain reaction-direct sequencing (PCR-DS) 138 AS patients and 141 healthy controls. genotype distribution control group checked status Hardy–Weinberg equilibrium (HWE). Odds ratio (OR) 95% confidence interval (95%CI) calculated χ2 test used show effects on risk. Logistic regressive analysis calculate...
Abstract Backgroud: During various stages of fracture healing, macrophages control mesenchymal stem cells' (BMSCs') proliferative behavior and osteogenic differentiation through varying polarization states. BMSCs also regulate their own the state to meet requirements tissue repair environment. A crucial role in cell proliferation, differentiation, death is played by evolutionarily conserved Notch signaling system. It plays an important regulation macrophage BMSCs. The NOTCH pathway typically...