A5059033623- Receptor Mechanisms and Signaling
- Medicinal Plant Research
- Neuropeptides and Animal Physiology
- Phosphodiesterase function and regulation
- Curcumin's Biomedical Applications
- Natural Products and Applications
- Food and Agricultural Sciences
- Seaweed-derived Bioactive Compounds
- Protein Kinase Regulation and GTPase Signaling
- Medicinal Plants and Neuroprotection
- Proteoglycans and glycosaminoglycans research
- Synthesis and Catalytic Reactions
- Signaling Pathways in Disease
- Pharmacological Receptor Mechanisms and Effects
- Melanoma and MAPK Pathways
- Adenosine and Purinergic Signaling
- Pharmacological Effects of Medicinal Plants
- Agricultural and Biological Research
- Diverse Scientific Research Studies
- Allelopathy and phytotoxic interactions
- Cell death mechanisms and regulation
- Cancer and biochemical research
- Diabetes Treatment and Management
- Essential Oils and Antimicrobial Activity
- Chemical synthesis and alkaloids
Bandung Institute of Technology
2014-2022
University of Cambridge
2019-2022
Politeknik Kesehatan Kementerian Kesehatan Jakarta II
2018
Indra (Spain)
2018
Abstract The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity GPCRs to couple multiple intracellular signalling pathways. This promiscuous coupling leads numerous downstream cellular effects, some which are therapeutically undesirable. especially case adenosine A 1 (A Rs) whose clinical potential undermined sedation and cardiorespiratory depression caused conventional agonists. We have discovered that R-selective agonist,...
Abstract The adenosine A 3 receptor (A R) belongs to a family of four (AR) subtypes which all play distinct roles throughout the body. R antagonists have been described as potential treatments for numerous diseases including asthma. Given similarity between (adenosine receptors) orthosteric binding sites, obtaining highly selective is challenging but critical task. Here we screen 39 R, using agonist-induced inhibition cAMP. Positive hits were assessed AR subtype selectivity through cAMP...
Abstract Agonist bias occurs when different ligands produce distinct signalling outputs acting at the same receptor. However, its physiological relevance is not always clear. Using primary human cells and gene editing techniques, we demonstrate endogenous agonist with consequences for calcitonin receptor-like receptor, CLR. By switching receptor-activity modifying protein (RAMP) associated CLR can “re-route” pathways activated by agonists gene-related peptide (CGRP), adrenomedullin (AM) 2...
This study was conducted to evaluate the potential benefit of particle reduction down nanoscale on curcumin, a unique natural active compound facing therapeutic problems due low solubility and permeability. In addition, presence TPGS as surfactant for multiple functions curcumin nanoparticle addressed. Observation focused bioavailability enhancement after oral administration local anti-inflammatory improvement rectal dosing. Nanonization performed using an up-scalable top method. Specific...
Curcumin, a hydrophobic polyphenol compound derived from the rhizome of Curcuma genus, has wide spectrum biological and pharmacological applications. Previously, curcumin nanoparticles with different stabilizers had been produced successfully in order to enhance solubility per oral absorption. In present study, we tested anti-inflammatory effect d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)-stabilized vivo. Lambda-carrageenan (λ-carrageenan) was used induce inflammation rats; it...
Abstract Gastric inhibitory polypeptide (GIP) receptor is a class B1 GPCR, that responds to GIP and physiologically potentiates glucose-stimulated insulin secretion. Like most GPCRs, GIPR has been shown interact with RAMPs, yet the effects of RAMPs on its signalling trafficking remain poorly understood. We demonstrate modulate G protein activation internalisation profiles. RAMP3 reduced s cAMP production but retained at cell surface, this was associated prolonged ERK1/2 phosphorylation...
Bromelain is a mixture of proteolytic enzymes presence in all tissues pineapple ( Ananas comosus ). It known for clinical use as debridement burn treatment. However, it easily degraded by light, high temperature and pH. Nanoemulsion bromelain promising to increase its stability. In this study, we investigated the nanoemulsion formulation into gel preparation order efficacy Spontaneous or self-nanoemulsifying was applied form (NEB). incorporated various types oil phase i.e virgin coconut...
Objective: This study aimed to determine antihyperlipidemic activity of binahong leaves and murbey extracts in combination.Methods: A total 28 rats were divided into seven groups: normal, control, simvastatin 3.6 mg/kg bw, extract 100 bw (B100), mulberry 200 (M200), combination 50 (B50+M100), (B100+M200). Hyperlipidemia was induced by giving a high fat diet along with cholesterol (200 mg/kg), cholic acid (0.2% chow), propylthiouracil (10 bw) for 30 days orally. Then, the next 14 days, all...
Abstract Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP, the A 2A receptor (A R) and phosphodiesterase 10A (PDE10A), are differentially co-expressed in various types non-small lung (NSCLC) cell-lines. Thus, finding dual-target compounds, which simultaneously agonists at R whilst also inhibiting PDE10A, could be novel anti-proliferative approach. Using ligand- structure-based modelling combined...
Objective: This study aimed to look for new agents from extracted Indonesia herbs which have antifungal activity with better safety profile against Candida albicans, Microsporum gypseum, and Trichophyton mentagrophytes. Methods: Screening of eleven was perform determine the highest activity. Minimum Inhibitory Concentration (MIC) Fungicidal (MFC) selected extracts, rosemary (Rosmarinus officinalis) leaves, Java turmeric (Curcuma xanthorriza) rhizome, ginger (Zingiber rhizome; were determined...
Curcumin, a hydrophobic polyphenol compound derived from the rhizome of Curcuma genus, has wide spectrum biological and pharmacological applications. Previously, curcumin nanoparticles with different stabilizers had been produced successfully in order to enhance solubility per oral absorption. In present study, we tested anti-inflammatory effect D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)-stabilized vivo. Lambda-carrageenan (λ-carrageenan) was used induce...
Summary The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity GPCRs to couple multiple intracellular signalling pathways. This promiscuous coupling leads numerous downstream cellular effects, some which are therapeutically undesirable. especially case adenosine A1 (A 1 Rs) whose clinical potential undermined sedation and cardiorespiratory depression caused conventional agonists. We have discovered that A R-selective agonist, BnOCPA, a...
Buah semangka adalah buah yang sering dijumpai dan dikonsumsi. Akan tetapi, pada umumnya hanya dikonsumsi daging buahnya saja, sedangkan kulit putihnya (mesokarp) seringkali menjadi limbah. Penelitian ini bertujuan untuk mengetahui efek antilelah ekstrak air mesokarp sehingga bisa dijadikan suplemen energi alami. Pengujian dilakukan dengan metode Weight-loaded Forced Swimming Test (WFST). Mencit Swiss Webster jantan dibagi empat kelompok, yaitu kelompok kontrol, uji diberikan dosis 1 g/kg...
Curcumin, a hydrophobic polyphenol compound derived from the rhizome of Curcuma genus has wide spectrum biological and pharmacological activities. Previously, curcumin nanocrystal with different stabilizers had been produced successfully in order to enhance solubility per oral absorption. In present study, we tested anti-inflammatory effect TPGS-stabilized vivo. Lambda-carrageenan was used induce inflammation rat, given by intraplantar route intrapelurally through surgery pleurisy test....
The paucity of currently available therapies for glioblastoma multiforme requires novel approaches to the treatment this brain tumour. Disrupting cyclic nucleotide-signalling through phosphodiesterase (PDE) inhibition may be a promising way suppressing growth. Here, we examined effects 28 PDE inhibitors, covering all major classes, on proliferation human U87MG, A172 and T98G cells. PDE10A inhibitors PF-2545920, PQ10 papaverine, PDE3/4 inhibitor trequinsin putative PDE5 MY-5445 potently...
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The banyan plant (Ficus benjamina Linn.) is one of the plants that has benefit as a traditional medicine. Almost all parts have efficacy source medicine and furniture or decoration. However, bark often considered waste. Based on results phytochemical screening been carried out, contains chemical compounds tannins, saponins, flavonoids, alkaloids glycosides. Flavonoids are group flavanols derived from benzene can be used basic natural dyes. Therefore, aim this research to try make herbal hair...
ABSTRACT G protein-coupled receptors (GPCRs) are the largest family of cell surface and a common drug target. They can be stabilised in different conformational states by ligands to activate multiple transducers effectors leading variety cellular responses. The potential agonists select pathways has important implications for discovery. Thus, there is clear need profile initial GPCR signal transduction event, activation proteins, enhance understanding receptor coupling guide design....
Abstract Agonist bias at G protein-coupled receptors has attracted considerable interest, although its relevance for physiologically-produced agonists is not always clear. Here, using primary human cells and gene editing techniques, we demonstrate the first time, endogenous agonist with physiological consequences calcitonin-like receptor (CLR). We reveal that by switching accessory protein: activity-modifying protein (RAMP) associated CLR can re-route pathways activated stimulating peptide...
<p>ABSTRACT<br />Objective: To determine the combination of extract Rosmarinus officinalis leaves, Zingiber officinale rhizome, and Curcuma xanthorrhiza rhizome in<br />2 form topical preparations, cream, ointment, through in situ study, as well to evaluate safety aspect both cream ointment.<br />Methods: Irritation skin eye test were performed according OECD guideline. Rabbits also used an object study. A suspension<br />of Trichophyton mentagrophytes was...
The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect weight loss. Since it will become longterm using, toxicity effectvresearch is needed. This study was conducted determine the subchronic ethanol extract (EEDS) belanda (EEJB) on kidney function, with parameters: urea creatinine, macroscopic histopathological kidney. were 120 Wistar rats (60 males, 60 females), 90 days (treatment group) (satellite group). Rats divided into six treatment groups. Test results...