Xin‐lu Cai

ORCID: 0000-0003-2260-4772
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About
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Research Areas
  • Functional Brain Connectivity Studies
  • Advanced Neuroimaging Techniques and Applications
  • Child and Adolescent Psychosocial and Emotional Development
  • Neural dynamics and brain function
  • Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Psychosomatic Disorders and Their Treatments
  • Neural and Behavioral Psychology Studies
  • Obsessive-Compulsive Spectrum Disorders
  • Schizophrenia research and treatment
  • Mental Health Research Topics
  • Empathy and Medical Education
  • Advanced MRI Techniques and Applications
  • Neurology and Historical Studies
  • Impact of Technology on Adolescents
  • Child Development and Digital Technology
  • Neuroendocrine regulation and behavior
  • Educational and Psychological Assessments
  • Youth Substance Use and School Attendance
  • Bipolar Disorder and Treatment
  • Gaze Tracking and Assistive Technology
  • Neuroscience and Neuropharmacology Research
  • Hereditary Neurological Disorders
  • Biochemical Analysis and Sensing Techniques
  • Spatial Neglect and Hemispheric Dysfunction
  • Fibromyalgia and Chronic Fatigue Syndrome Research

Hangzhou Normal University
2022-2024

East China Normal University
2024

Institute of Psychology, Chinese Academy of Sciences
2017-2022

Sino-Danish Centre for Education and Research
2017-2022

University of Chinese Academy of Sciences
2017-2022

Czech Academy of Sciences, Institute of Psychology
2019-2020

Chinese Academy of Sciences
2017-2019

Abstract Machine learning has increasingly been applied to classification of schizophrenia in neuroimaging research. However, direct replication studies and seeking investigate generalizability are scarce. To address these issues, we assessed within‐site between‐site a machine framework which achieved excellent performance previous study using two independent resting‐state functional magnetic resonance imaging data sets collected from different sites scanners. We established the main set...

10.1002/hbm.24797 article EN cc-by Human Brain Mapping 2019-10-01

Schizotypy refers to schizophrenia-like traits below the clinical threshold in general population. The pathological development of schizophrenia has been postulated evolve from initial coexistence 'brain disconnection' and connectivity compensation' decompensation'.In this study, we examined brain changes associated with schizotypy by combining white matter structural connectivity, static dynamic functional analysis diffusion tensor imaging data resting-state magnetic resonance data. A total...

10.1017/s0033291720002445 article EN Psychological Medicine 2020-07-17

Cerebellar dysfunction is associated with neurological soft signs (NSS), which a promising endophenotype for schizophrenia spectrum disorders. However, the relationship between cerebellar-cerebral resting-state functional connectivity (rsFC) and NSS largely unexplored. Moreover, both rsFC have been found to be correlated negative symptoms of schizophrenia. Here, we investigated correlations rsFC, explored their in main dataset, validated significant findings replication dataset. Both...

10.1093/schbul/sbaa200 article EN Schizophrenia Bulletin 2020-12-29

Functional magnetic resonance imaging is capable of estimating functional activation and connectivity in the human brain, lately there has been increased interest use these modalities combined with machine learning for identification psychiatric traits. While methods bear great potential early diagnosis better understanding disease processes, are wide ranges processing choices pitfalls that may severely hamper interpretation generalization performance unless carefully considered. In this...

10.1093/schbul/sby026 article EN Schizophrenia Bulletin 2018-02-28

The adverse effects of smartphone addiction (SPA) and Internet gaming disorder (IGD) on adolescents' mental health have been widely recognized. However, the influence parenting styles these high-risk use behaviors adolescents still remain elusive. Aiming to identify preventable patterns for with SPA or IGD, this study compared status between IGD used path analysis confirm actual IGD.Participants were enrolled at a junior high school in Hunan Province senior Shanxi Province, China [n = 3,049,...

10.3389/fpsyg.2022.1044190 article EN cc-by Frontiers in Psychology 2022-12-14

Alterations of empathy have been observed in patients with various mental disorders. The Perth Empathy Scale (PES) was recently developed to measure a multidimensional construct across positive and negative emotions. However, its psychometric properties clinical applications not examined the Chinese context.

10.1002/jclp.23643 article EN Journal of Clinical Psychology 2024-01-18

A phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little known about neurobiological basis of schizo-obsessive (SOC). We aimed to investigate whether specific changes white matter exist SOC and relationship between such abnormalities clinical parameters. Twenty-eight SOC, 28 patients, 30 OCD demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics Probabilistic...

10.1093/schbul/sbz073 article EN Schizophrenia Bulletin 2019-06-18

Using Chinese characters, we investigated how stroke count and frequency of use influence attention short-term memory (STM) encoding in Mainland speakers. To isolate specific components employed the Theory Visual Attention (TVA), which allowed estimates STM capacity, processing speed, threshold visual perception. An analysis TVA parameters revealed that familiarity affects both capacity speed objects, whereas for perception remained unaffected. Interestingly, our results also indicate...

10.1037/xlm0000950 article EN Journal of Experimental Psychology Learning Memory and Cognition 2020-09-03

Background Childhood trauma has been found to have an important impact on mental health. However, little is known regarding the intercorrelations between childhood and health during COVID-19 pandemic. This study aimed investigate such complex interplay trauma, depression, anxiety, post-traumatic stress level pandemic, fear of using network analysis. Methods A total 1,247 college students were recruited asked complete a series questionnaires, including Trauma Questionnaire, Patient Health...

10.3389/fpsyt.2023.1251473 article EN cc-by Frontiers in Psychiatry 2023-09-08

Introduction Alteration of empathy is common in patients with psychiatric disorders. Reliable and valid assessment tools for measuring clinical samples needed. The Questionnaire Cognitive Affective Empathy (QCAE) a newly-developed instrument to capture cognitive affective components empathy. This study aimed validate the QCAE compared self-reported between groups varied diagnoses healthy sample.Methods present performed factor analysis on Chinese setting (n = 534), including schizophrenia...

10.1080/13546805.2020.1846025 article EN Cognitive Neuropsychiatry 2020-11-01

Background The alexithymia trait is of high clinical interest. Perth Alexithymia Questionnaire (PAQ) was recently developed to enable detailed facet-level and valence-specific assessments alexithymia. Aims In this paper, we introduce the first Chinese version PAQ examine its psychometric properties applications. Methods Study 1, administered 990 participants. We examined factor structure, internal consistency, test-retest reliability, as well convergent, concurrent discriminant validity. 2,...

10.1136/gpsych-2023-101281 article EN cc-by-nc General Psychiatry 2024-03-01

IntroductionInvestigating obsessive-compulsive symptoms in subclinical populations provides a useful framework for understanding the early development of spectrum disorders. The present study aimed to apply searchlight classification analysis on resting-state functional magnetic resonance imaging data identify potential brain markers individuals with symptoms.MethodsIn this observational study, 40 college students high symptom scores and low were recruited from universities China. We...

10.1080/13546805.2019.1658575 article EN Cognitive Neuropsychiatry 2019-08-26

Glutamatergic dysfunction has been implicated in sensory integration deficits schizophrenia, yet how glutamatergic function contributes to behavioural impairments and neural activities of remains unknown.Fifty schizophrenia patients 43 healthy controls completed assessments for underwent magnetic resonance spectroscopy (MRS) measuring the anterior cingulate cortex (ACC) glutamate levels. The correlation between levels was examined each group. A subsample 20 pairs further an audiovisual...

10.1017/s0033291722001817 article EN Psychological Medicine 2022-07-06

This Chinese translation of the Perth Empathy Scale (PES) was translated from original English version. An initial to conducted and refined by authorship team. These items were then back-translated into a translator with CATTI certification. Minor refinements some made team on basis this back-translation, resulting in final version PES presented document. Our has published psychometric study examine its validity reliability. 该中文翻译版珀斯共情量表(the...

10.31234/osf.io/5sd8b preprint EN 2024-01-19

Abnormalities of regulating positive and negative emotion have been documented in patients with mental disorders. Valid reliable psychological instruments for measuring regulation across different valences are needed. The Perth Emotion Regulation Competency Inventory (PERCI) is a 32-item self-report measure recently developed to compressively assess ability both valences.

10.2147/prbm.s478246 article EN cc-by-nc Psychology Research and Behavior Management 2024-09-01
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