A5100691903- Autoimmune and Inflammatory Disorders
- Hidradenitis Suppurativa and Treatments
- Microscopic Colitis
- Inflammatory Bowel Disease
- Autoimmune Bullous Skin Diseases
- Nonmelanoma Skin Cancer Studies
- Tumors and Oncological Cases
- Mycobacterium research and diagnosis
- Cutaneous Melanoma Detection and Management
- Colorectal and Anal Carcinomas
- Systemic Lupus Erythematosus Research
- Genetic and rare skin diseases.
- Skin Diseases and Diabetes
- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Chronic Lymphocytic Leukemia Research
- Management of metastatic bone disease
- Magnesium in Health and Disease
- Insect Pheromone Research and Control
- Gastrointestinal Bleeding Diagnosis and Treatment
- Blood disorders and treatments
- Psoriasis: Treatment and Pathogenesis
- Medical Device Sterilization and Disinfection
- Soft tissue tumors and treatment
- Healthcare Systems and Technology
Hospital Braga
2024
Centro Hospitalar do Tâmega e Sousa
2023
Hospital de São João
2017-2023
Shionogi (Japan)
2020
Christie's
2019
Institut Gustave Roussy
2013
Abstract Background Faecal urgency (FU) is relatively neglected yet common among patients with inflammatory bowel disease (IBD) and has been correlated activity1,2. Its presence in ulcerative colitis easily understood; however, Crohn's (CD), where lesions are more proximal regions such as the ileum or right colon while left remain unaffected, of FU less straightforward. This study aims to compare prevalence severity CD involvement versus those distal involvement, using splenic flexure a...
Patients with inflammatory bowel diseases are prone to cutaneous manifestations. The aim of this study was investigate their prevalence, type and association demographic clinical factors.This a cross-sectional study. Information relative patients central Portuguese hospital definitive diagnosis an disease, who were prospectively recruited, collected.The final cohort included 342 patients, 62% whom had Crohn's disease 38% ulcerative colitis. Cutaneous extraintestinal manifestations present in...
Treatment of pyoderma gangrenosum (PG) remains a challenge, and there are currently no specific or uniformly effective therapies. Although widespread rapidly progressive disease often requires systemic treatment, localised mild lesions may be effectively controlled with topical agents. The most frequently applied drugs corticosteroids calcineurin inhibitors. Recently, patient idiopathic PG the lower limb was successfully treated timolol collagenase. Here, we report case collagenous colitis,...
Dermatitis neglecta is a condition affecting the skin caused by lack of hygiene. It may be related to psychiatric and neurological disturbances. The appearance lesions results from neglect, which helps distinguish this other similar clinical entities. Resolution with adequate cleansing aids definitive diagnosis.
Abstract Background Upadacitinib (UPA) demonstrated efficacy and safety in the phase 3 U-EXCEED (NCT03345836) U-EXCEL (NCT03345849) induction, U-ENDURE (NCT03345823) maintenance trials patients (pts) with moderately to severely active Crohn’s disease (CD). We evaluated impact of UPA on health-related quality life (QoL) pts CD. Methods Clinical responders 45 mg (UPA45) induction were re-randomised at Week 12 (1:1:1) 15 (UPA15), 30 (UPA30), or placebo (PBO) for 52 weeks treatment U-ENDURE;...
ResultsThe overall response rate was 62% (366 of 593), with 283 women (77%).Among the respondents, 187 were GP residents in their 1st year (51%), 84 2nd (23%), 58 3rd (16%), 21 4th (6%), and 16 consultants (4%; Table 1).For a patient boils and/or recurrent cysts located at folds, 327 considered diagnosis HS (90%), whereas 35 did not (10%), no significant difference responses according to years experience (p = 0.429).In addition, 169 (46%) reported evaluating
Recognition of facial lentigo maligna (LM) is often difficult, particularly at early stages. Algorithms and multivariate diagnostic models have recently been elaborated on the attempt to improve accuracy. We conducted a cross-sectional retrospective study evaluate dermatoscopic criteria aiding in diagnosis flat pigmented lesions (FPFL). examined 46 FPFL 42 Caucasian patients found that 4 20 reached significance level required for features indicating malignancy namely, hyperpigmented...
Systemic inflammatory diseases such as psoriasis, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) are associated with an increased prevalence of cardiovascular (CVD) other comorbidities. The primary aim this study was to assess the screening practices general practitioners (GPs) regard most frequent comorbidities in patients psoriasis.We adapted, permission, a questionnaire that used by Parsi et al. 2012, which then distributed GP residents consultants.Overall, 372...
Hidradenitis suppurativa (HS) is a chronic and recurrent inflammatory disease characterized by the presence of painful deep lesions usually located in intertriginous areas. It rarely occurs children, especially prepubertal age. Treatment for HS this age group challenging considering scant data available risk adverse effects younger patients. We report case 10-year-old girl with Hurley III HS, refractory to multiple topical systemic therapies. After introducing adalimumab, there was...
Alopecia areata (AA) is a form of nonscarring alopecia and one the most common autoimmune disorders. Persistent or severe variants lead to potential disfigurement are associated with significant negative impact on patient's quality life.A 51-year-old female patient presenting refractory universalis was successfully treated oral tofacitinib. Recurrence not observed following 17 months therapy.None currently employed therapies for AA reliably effective nor they approved disease. In this...
Lyme disease is a tick-borne infectious caused by the spirochete
O objetivo deste estudo foi identificar quais os graus de insolvência das companhias capital aberto do setor agronegócio da B3 nos últimos 6 anos, conforme as informações contábeis aplicadas ao Termômetro Kanitz. Para atingir este objetivo, critérios selecionados foram utilizados determinando a importância destes rácios financeiros para previsão insolvabilidade empresa por meio análises, sendo elas análises estatísticas e aplicação técnicas análise discriminantes. tal, delineou-se pesquisa...
Necrobiotic xanthogranuloma (NXG) is a rare form of inflammatory granulomatous disease the skin characterized by presence pruritic to painful lesions, generally located in periorbital area, although trunk and proximal extremities may also be involved. We report case 69-year-old male patient with extensive involvement trunk, upper lower extremities, an associated gamma monoclonal gammopathy. The biopsy was consistent diagnosis NXG. Necrobiosis lipoidica granuloma annulare were major...
Introduction: Systemic inflammatory diseases such as psoriasis, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) are associated with an increased prevalence of cardiovascular (CVD) other comorbidities.The primary aim this study was to assess the screening practices general practitioners (GPs) regard most frequent comorbidities in patients psoriasis.Methods: We adapted, permission, a questionnaire that used by Parsi et al. 2012, which then distributed GP residents...
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Systemic immunoglobulin light chain amyloidosis is the most common and severe type of amyloidosis. There an abnormal fibrillary protein deposition in tissues that leads to progressive irreversible organ dysfunction. The commonly affected organs are kidney heart. Although rare, cutaneous manifestations may be first clinical sign disease usually present as hemorrhagic lesions, such purpura, petechiae, ecchymosis. We a 71-year-old man presented our department because exuberant purpuric plaques...