A5068589257- Acne and Rosacea Treatments and Effects
- Osteoarthritis Treatment and Mechanisms
- Viral Infections and Immunology Research
- Nail Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Knee injuries and reconstruction techniques
- Skin Protection and Aging
- Cardiovascular Function and Risk Factors
- Lower Extremity Biomechanics and Pathologies
- Autism Spectrum Disorder Research
- melanin and skin pigmentation
- Genetics and Neurodevelopmental Disorders
- Cardiac pacing and defibrillation studies
- Advanced Causal Inference Techniques
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Cancer Research and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Silk-based biomaterials and applications
- Genetic Neurodegenerative Diseases
- Muscle Physiology and Disorders
- Neurological disorders and treatments
- Cutaneous lymphoproliferative disorders research
- Cardiac Ischemia and Reperfusion
Vital Research
2014-2023
Carrick Institute
2019
Stephens College
2019
Statistical Research (United States)
2013-2014
Celladon Corporation (United States)
2008-2013
Hospital of the University of Pennsylvania
2011-2013
University of California San Diego Medical Center
2011-2013
Piramal (Canada)
2013
San Diego Cardiac Center
2011
Columbia University
2011
Adeno-associated virus type 1/sarcoplasmic reticulum Ca(2+)-ATPase was assessed in a randomized, double-blind, placebo-controlled, phase 2 study patients with advanced heart failure.Thirty-nine received intracoronary adeno-associated or placebo. Seven efficacy parameters were 4 domains: symptoms (New York Heart Association class, Minnesota Living With Failure Questionnaire), functional status (6-minute walk test, peak maximum oxygen consumption), biomarker (N-terminal prohormone brain...
The Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In Cardiac Disease (CUPID 1) study was a phase 1/phase 2 first-in-human clinical gene therapy trial using an adeno-associated virus serotype 1 (AAV1) vector carrying the sarcoplasmic reticulum calcium ATPase (AAV1/SERCA2a) in patients with advanced heart failure. explored potential benefits at 12 months, and results were previously reported.To report long-term (3-year) effects transgene expression CUPID 1.A total 39...
Mesenchymal precursor cells (MPCs) are allogeneic, immunoselected with anti-inflammatory properties that could improve outcomes in heart failure reduced ejection fraction (HFrEF). This study assessed the efficacy and safety of MPCs patients high-risk HFrEF. randomized, double-blind, multicenter evaluated a single transendocardial administration procedure or sham-control 565 intention-to-treat HFrEF on guideline-directed therapies. The primary endpoint was time-to-recurrent events caused by...
<h2>Abstract</h2><h3>Background</h3> We analyze the safety and tolerability of trofinetide provide a preliminary evaluation its efficacy in adolescent adult males with fragile X syndrome. <h3>Methods</h3> This study was an exploratory, phase 2, multicenter, double-blind, placebo-controlled, parallel group orally administered 72 Subjects were randomly assigned 1:1:1 ratio to 35 or 70 mg/kg twice daily placebo for 28 days. Safety assessments included adverse events, clinical laboratory tests,...
In vitro electromechanical and biomechanical testing of articular cartilage provide critical information about the structure function this tissue. Difficulties obtaining fresh tissue lengthy experimental procedures often necessitate a storage protocol, which may adversely affect functional properties cartilage. The effects at either 4°C for periods 6 days 12 days, or during single freeze-thaw cycle −20°C were examined in young bovine Non-destructive measurements unconfined compression on 3...
BackgroundGSK3β is an intracellular regulatory kinase that dysregulated in multiple tissues type 1 myotonic dystrophy, a rare neuromuscular disorder manifests at any age. AMO-02 (tideglusib) inhibits GSK3β activity preclinical models of dystrophy and promotes cellular maturation as well normalizes aberrant molecular behavioral phenotypes. This phase 2 study assessed the pharmacokinetics, safety tolerability, preliminary efficacy adolescents adults with congenital childhood-onset...
This paper considers the analysis of a repeat event outcome in clinical trials chronic diseases context dependent censoring (e.g. mortality). It has particular application recurrent heart failure hospitalisations failure. Semi‐parametric joint frailty models (JFMs) simultaneously analyse and time to cardiovascular death, estimating distinct hazard ratios whilst individual‐specific latent variables induce associations between two processes. A simulation study was carried out assess...
Recent advances in the development of new drugs to halt or even reverse progression Osteoarthritis at an early-stage requires tools detect early degeneration articular cartilage. We investigated ability electromechanical probe and automated indentation technique characterize entire human surfaces for rapid non-destructive discrimination between degenerated healthy Human cadaveric asymptomatic (four pairs distal femurs four tibial plateaus) were used. They assessed ex vivo: macroscopically,...
Recurrent event data arise frequently in longitudinal medical studies. In many situations, there are a large portion of subjects without any recurrent events, manifesting the "zero-inflated" nature data. Some zero events may be "structural zeros" as patients unsusceptible to while others "random due censoring before events. On other hand, often exists terminal which correlated with this article, we propose two joint frailty models for zero-inflated presence event, combining logistic model...
Current cartilage repair histological scoring systems are unable to explain the relationship between collagen type II deposition and overall quality.The purpose of this study was develop a novel zonal (ZCT) 5-point system measure chondroinduction in human clinical biopsy specimens collected after marrow stimulation. The hypothesis that ZCT scores would correlate with International Cartilage Repair Society-II (ICRS-II) assessment score glycosaminoglycan (GAG) content.Descriptive laboratory...
Malassezin is a natural indole compound produced by the fungus Malassezia furfur and preclinical investigations have demonstrated an ability to suppress melanogenesis.To investigate histopathological effects of malassezin for treatment facial hyperpigmentation.In this proof-of-concept study, seven subjects with hyperpigmentation caused melasma or photodamage applied topical twice daily 14 weeks, followed eight weeks observation. At baseline, 2 mm punch biopsies were taken from hyperpigmented...