A5029011325- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Click Chemistry and Applications
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Biotin and Related Studies
- Advanced Biosensing Techniques and Applications
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Nitric Oxide and Endothelin Effects
- Analytical Chemistry and Sensors
- Advanced Nanomaterials in Catalysis
- Synthesis and biological activity
- Neuroscience of respiration and sleep
- Metal-Organic Frameworks: Synthesis and Applications
- Synthesis and bioactivity of alkaloids
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Lanthanide and Transition Metal Complexes
- Microbial bioremediation and biosurfactants
- Synthesis and Reactivity of Heterocycles
- Pesticide and Herbicide Environmental Studies
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
- Monoclonal and Polyclonal Antibodies Research
Osaka University
2019-2024
University of Guelph
2019
Guru Nanak Dev University
2012-2017
Indian Institute of Management Amritsar
2014-2017
Centre of Advanced Studies
2014-2017
A TICT based NIR-fluorescent probe 3 has been designed and synthesized, which selectively detects HSA with fluorescence enhancement in blood plasma a detection limit of 11 nM among the various proteins, nucleotides thiols tested.
An oxime based fluorescent probe has been designed and synthesized, which detects free as well enzymatically generated hypochlorite. Further, the was successfully utilized for monitoring endogenously produced
A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (H2O2) with high selectivity sensitivity in brain tissues living nematodes among various ROS/RNS tested. Further, the LyNC was successfully employed exogenous endogenous imaging of H2O2 cell lines.
A chemosensor 3 based on the N,N-dimethylaminocinnamaldehyde has been synthesized which shows fluorescence turn-on response with Hg(2+) ions, and in situ prepared 3-Hg(2+) complex used for detection of picric acid via electrostatic interaction construction a combinatorial logic circuit NOR INHIBIT functions.
A bodipy based probe <bold>1</bold> has been explored for the identification of diseased cell population out normal cells on basis changes in intracellular viscosity.
A bodipy based dual functional probe<bold>1</bold>has been designed and synthesized, which selectively detects H<sub>2</sub>S as well monitors induced apoptosis in cells.
A thiacalix[4]arene-fluorescein based fluorescent probe for detection of CN<sup>−</sup> and Cu<sup>2+</sup> ions its application in a sequential logic circuit.
Abstract A fluorescein‐based fluorescent probe has been designed and synthesised that selectively detects H 2 S in aqueous medium, among various analytes tested. This also successfully utilised for real‐time imaging of exo‐ endogenously produced cancer cells normal cells. Moreover, the can detect rat brain hippocampus at variable depths living nematodes.
A d-PET coupled ESIPT based probe has been designed and synthesized for the selective detection of H2S, among other ions various sulfur species such as cysteine glutathione, in aqueous media via hydrogen sulfide induced reduction nitro functionalities, further utilized imaging H2S intracellular systems.
A rhodamine-phenanthroline dyad based fluorescent probe 4 has been designed and synthesized which selectively monitors Fe3+ ions among the various metal tested. Furthermore, explored for monitoring of dynamic changes in ion level under aggressive Fenton reaction conditions using a cell model study. More significantly, also utilized real time imaging endogenous living C6 lines, results demonstrated that acts as an efficient tool detection biological systems.
An efficient synthesis of 4-arylquinoline-2-carboxylates and their antioxidant, neuroprotective P-glycoprotein induction activity have been described.
A naphthalimide-based fluorescent probe, LyNP-NO, was designed and synthesized for the selective detection of exogenously endogenously generated nitric oxide (NO) in C6 glial cells. In addition, LyNP-NO also explored monitoring endogenous NO levels rat hippocampus at various tissue depths by stimulating brain with N-methyl-d-aspartate (NMDA).
A thiacalix[4]crown based di topic receptor <bold>3</bold> has been synthesized which shows negative allosteric behaviour between Zn<sup>2+</sup>/K<sup>+</sup> ions. Further, <bold>3</bold>-Zn<sup>2+</sup> complex used for detection of H<sub>2</sub>PO<sup>4−</sup>.
An “OFF–ON–OFF” fluorescence probe for real-time imaging of the expression (fluorescence ‘OFF’) and degradation ‘ON’) short lived PYP-tag proteins in cellular systems.
A new rhodamine–azaindole based fluorescence probe for Cu<sup>2+</sup> has been synthesized which shows resonance energy transfer process in acetonitrile. Further, the undergoes promoted hydrolysis mixed aqueous media as well intracellular systems.