A5041428404- Neuroinflammation and Neurodegeneration Mechanisms
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Neurogenesis and neuroplasticity mechanisms
- Brain Tumor Detection and Classification
- EEG and Brain-Computer Interfaces
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Blockchain Technology Applications and Security
- IoT and Edge/Fog Computing
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Pharmaceutical Quality and Counterfeiting
- Axon Guidance and Neuronal Signaling
- Memory and Neural Mechanisms
- Advanced Steganography and Watermarking Techniques
- User Authentication and Security Systems
- Alkaloids: synthesis and pharmacology
- Advanced Memory and Neural Computing
- Nitric Oxide and Endothelin Effects
- Glioma Diagnosis and Treatment
- Apelin-related biomedical research
- Metal-Organic Frameworks: Synthesis and Applications
- Medicinal Plants and Neuroprotection
- Neuroscience of respiration and sleep
Chandigarh University
2023-2024
Jain University
2024
University of Illinois Chicago
2021-2024
Illinois College
2024
University of Illinois Urbana-Champaign
2024
Indira Gandhi Delhi Technical University for Women
2022-2023
M S Ramaiah University of Applied Sciences
2022
ABES Engineering College
2022
Institute of Management Technology
2022
Guru Nanak Dev University
2015-2020
A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (H2O2) with high selectivity sensitivity in brain tissues living nematodes among various ROS/RNS tested. Further, the LyNC was successfully employed exogenous endogenous imaging of H2O2 cell lines.
Hippocampal neurogenesis is impaired in Alzheimer’s disease (AD) patients and familial (FAD) mouse models. However, it unknown whether new neurons play a causative role memory deficits. Here, we show that immature were actively recruited into the engram following hippocampus-dependent task. their recruitment severely deficient FAD. Recruited exhibited compromised spine density altered transcript profile. Targeted augmentation of FAD mice restored number engram, dendritic density,...
Abstract Brain tumor classification using MRI images is a crucial yet challenging task in medical imaging. Accurate diagnosis vital for effective treatment planning but often hindered by the complex nature of morphology and variations Traditional methodologies primarily rely on manual interpretation images, supplemented conventional machine learning techniques. These approaches lack robustness scalability needed precise automated classification. The major limitations include high degree...
Here, we provide an in-depth consideration of our current understanding engrams, spanning from molecular to network levels, and hippocampal neurogenesis, in health Alzheimer's disease (AD). This review highlights novel findings these emerging research fields future directions for therapeutic avenues memory failure dementia. Engrams, AD, neurogenesis have each been extensively studied. The integration topics, however, has relatively less deliberated, is the focus this review. We primarily on...
Abstract Sleep deprivation (SD) leads to the spectrum of mood disorders like anxiety, cognitive dysfunctions and motor coordination impairment in many individuals. However, there is no effective pharmacological remedy negate effects SD. The current study examined whether 50% ethanolic extract Tinospora cordifolia (TCE) can attenuate these negative Three groups adult Wistar female rats - (1) vehicle treated-sleep undisturbed (VUD), (2) deprived (VSD) (3) TCE (TSD) animals were tested...
A bodipy based probe <bold>1</bold> has been explored for the identification of diseased cell population out normal cells on basis changes in intracellular viscosity.
A bodipy based dual functional probe<bold>1</bold>has been designed and synthesized, which selectively detects H<sub>2</sub>S as well monitors induced apoptosis in cells.
Abstract A fluorescein‐based fluorescent probe has been designed and synthesised that selectively detects H 2 S in aqueous medium, among various analytes tested. This also successfully utilised for real‐time imaging of exo‐ endogenously produced cancer cells normal cells. Moreover, the can detect rat brain hippocampus at variable depths living nematodes.
A naphthalimide-based fluorescent probe, LyNP-NO, was designed and synthesized for the selective detection of exogenously endogenously generated nitric oxide (NO) in C6 glial cells. In addition, LyNP-NO also explored monitoring endogenous NO levels rat hippocampus at various tissue depths by stimulating brain with N-methyl-d-aspartate (NMDA).
Neuroinflammation is a major risk factor associated with the pathogenesis of neurodegenerative diseases. Conventional non-steroidal anti-inflammatory drugs are prescribed but their long term use adverse effects. Thus, herbal based medicines attracting attraction worldwide as potential therapeutic candidates. Tylophora indica (Burm. f) Merrill valuable medicinal plant well known in Ayurvedic practices for its immunomodulatory, anti-oxidant, anti-asthmatic and antirheumatic activities. The...
Counterfeit drugs are an immense threat for the pharmaceutical industry worldwide due to limitations of supply chain. Our proposed solution can overcome many challenges as it will trace and track while in transit, give transparency along with robust security ensure legitimacy across It provides a reliable certification process well. Fabric architecture is permissioned private. Hyperledger preferred framework over Ethereum because makes use features like modular design, high efficiency,...
Abstract Precise monitoring and diagnosis of epilepsy by manual analysis EEG signals are challenging due to the low doctor‐to‐patient ratio, shortage medical resources. To automate this in real‐time, based Brain–Computer Interface (BCI) system with integration artificial intelligence techniques will prove be propitious. This work proposes an end‐to‐end, one‐dimensional atrous conv‐net‐based architecture for automatic using a conceptual framework EEG‐BCI routine clinical use. The proposed has...
It is unknown whether adult-born hippocampal neurons play a role in memory deficits Alzheimer’s disease (AD). Here we show that significantly less new granule neurons, but similar number of mature were recruited into contextual engram ensemble mouse model AD compared to wild type. Augmentation neurogenesis mice increased the and restored memory. The correlated with strength Chemogenetic inactivation following enhanced AD, reversed performance diminished Collectively, these observations...
Epilepsy is a rapidly spreading chronic, ne\-rve illness which results from recurring seizures and has an annual impact on more than five million individuals worldwide. Precise treatment diagnosis by manual analysis of EEG signals, MRI, CT scans are still challenging due to the low doctor-to-patient ratio, shortage medical resources. Hence, researchers have taken help Brain-Compu\-ter Interfacing (BCI) systems Artificial Intelligence (AI) methods expedite this task develop real-time,...