A5064755492- Electroconvulsive Therapy Studies
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Schizophrenia research and treatment
- Takotsubo Cardiomyopathy and Associated Phenomena
- Pharmacy and Medical Practices
- Transcranial Magnetic Stimulation Studies
- Intensive Care Unit Cognitive Disorders
- Perfectionism, Procrastination, Anxiety Studies
- Family Caregiving in Mental Illness
- Neurological and metabolic disorders
- Diabetes and associated disorders
- Cardiac pacing and defibrillation studies
- Neurological disorders and treatments
- Folate and B Vitamins Research
- Tryptophan and brain disorders
- Epilepsy research and treatment
- Prenatal Substance Exposure Effects
- Atomic and Subatomic Physics Research
- Pharmacological Effects and Toxicity Studies
- Cardiac Arrhythmias and Treatments
- Cardiac tumors and thrombi
- Alcoholism and Thiamine Deficiency
- Functional Brain Connectivity Studies
- Anesthesia and Sedative Agents
Kyoto University
2019-2025
Kyoto University Hospital
2022-2025
Toyooka Hospital
2014-2024
Kansai Medical University
2023
University of Yamanashi
2023
Ketamine, a rapid-acting antidepressant, has undesirable psychotomimetic effects, including dissociative effect. There is currently no effective strategy to suppress these side effects while preserving its antidepressant Here, we investigated the of D2/D3 receptor antagonist and partial agonists on ketamine in mice humans. Aripiprazole, agonist, attenuated effect, but maintaining even enhancing antidepressant-like effect forced swim test, whereas raclopride, an antagonist, suppressed both...
Abstract Background Seizure threshold increases with age and the frequency of electroconvulsive therapy (ECT). Therefore, therapeutic seizures can be difficult to induce, even at maximum stimulus charge available ECT devices. Such cases are known as difficult-to-induce-seizures (DECs). However, no clinical guidelines exist for DECs; thus, clinicians often face difficulties determining treatment strategies. This study aimed obtain a consensus among experts regarding DECs. Methods We asked...
Electroconvulsive therapy (ECT) is one of the most effective treatments for depression and schizophrenia, particularly in urgent or treatment-resistant cases. After ECT, regional gray matter volume (GMV) increases have been repeatedly reported both schizophrenia. However, interpretation these findings remains entangled because GMV changes do not necessarily correlate with treatment effects may be influenced by intervention itself. We hypothesized that comparison longitudinal magnetic...
Abstract: Inducing adequate therapeutic seizures during electroconvulsive therapy is sometimes difficult, even at the maximum stimulus charge, due to a high seizure threshold. Here, we describe two patients with very poor responses charge using conventional parameters in whom were successfully augmented by widening pulse width same or lower charge. This strategy could be an additional option for augmentation clinical practice. The potential utility of parameter modifications should further...
Abstract Background Post-stroke delirium affects between 24% and 43% of patients, negatively impacts patient outcomes. Recently, research attention has been on preventive interventions for delirium, with melatonin receptor agonists orexin antagonists reported to be effective in preventing intensive care unit patients. However, the efficacy these agents post-stroke remain unclear. This study examined ramelteon, suvorexant, lemborexant symptoms patients stroke. Methods A retrospective survey...
Inducing adequate therapeutic seizures during electroconvulsive therapy (ECT) is sometimes difficult due to a high seizure threshold, even at the maximum stimulus charge. Previous studies have demonstrated that threshold lower in patients treated with right unilateral ultrabrief pulse (RUL-UBP) ECT than those bilateral or brief (BL-BP) ECT. Therefore, switching RUL-UBP may be beneficial for whom induction conventional In present report, we discuss case of patient suffering from catatonic...
Abstract Background The weaknesses of classical explanatory randomized controlled trials (RCTs) include limited generalizability, high cost, and time burden. Pragmatic RCTs nested within electronic health records (EHRs) can be useful to overcome such limitations. Serum lithium monitoring has often been underutilized in real-world practice Japan. This trial aims evaluate the effectiveness EHR-nested reminder system for serum level maintenance therapeutic concentration improvement quality care...
To provide an overview of how electroconvulsive therapy (ECT) practice in Japan has changed as the coronavirus disease 2019 (COVID-19) pandemic continues.We surveyed healthcare institutions, primarily university and general hospitals, regarding changes number patients undergoing ECT infection control measures early (August 2020) recent 2021) stages COVID-19 pandemic. Data for were also compared between urban non-urban areas.Among 32 facilities, decreased 11 facilities (34.4%) from April 2020...
Background Clinical guidelines recommend regular serum lithium monitoring every 3 to 6 months. However, in the real world, only a minority of patients receive adequate monitoring. Objective This study aims examine whether use electronic health record (EHR)–nested reminder system for can help achieve concentrations within therapeutic range on maintenance therapy. Methods We conducted an unblinded, single-center, EHR-nested, parallel-group, superiority randomized controlled trial comparing...
Lurasidone has few metabolic adverse effects and is recommended as an alternative when other antipsychotic drugs considerably increase body weight or blood sugar concentrations.An 81-year-old man with bipolar disorder developed hyperosmolar hyperglycemic syndrome a side effect of lurasidone. Routine monitoring glucose concentrations led to the early detection treatment this disease, preventing life-threatening complications.We describe rare case lurasidone-induced syndrome. The mortality...
Hemorrhage inside the mammillary bodies (MMBs) is known to be one of findings Wernicke encephalopathy. Brain MRI two patients with Wernicke-Korsakoff syndrome (WKS) demonstrated high susceptibility values representing hemosiderin deposition in MMBs by using quantitative mapping (QSM). QSM provided additional information susceptibility-weighted imaging diagnosis WKS.
Abstract Electroconvulsive therapy (ECT) has been used as an effective treatment modality for psychiatric disorders. In patients with high seizure thresholds, augmentation strategies are considered such changing anesthetic agents, hyperventilation, and premedication theophylline. We tried to switch “long (1.5 ms)” brief pulse ECT in all six from October 2020. The successful induction of seizures “long” stimulation five who could not be treated adequately standard ECT. the current situation...
Abstract Background: The weaknesses of classical explanatory randomized controlled trials (RCTs) include limited generalizability, high cost, and time burden. Pragmatic RCTs nested within electronic health records (EHRs) can be useful to overcome such limitations. Serum lithium level monitoring has often been underutilized in real-world practice Japan. This trial aims evaluate the effectiveness EHR-nested reminder system for serum maintenance therapeutic concentration improvement quality...
A 76-year-old woman underwent 123I-FP-CIT brain SPECT due to postural reflex impairment. The transverse slices demonstrated increased uptake in the right middle cerebral artery territory. MR images obtained 2 weeks earlier showed infarction corresponding area. has high binding affinity for dopamine transporters, especially nerve endings of nigrostriatal dopaminergic neurons.