A5001987287- Hormonal and reproductive studies
- Pharmacology and Obesity Treatment
- Nonmelanoma Skin Cancer Studies
- Amoebic Infections and Treatments
- Lipoproteins and Cardiovascular Health
- Hedgehog Signaling Pathway Studies
- Health Systems, Economic Evaluations, Quality of Life
- Muscle metabolism and nutrition
- Sexual Differentiation and Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatitis Pathology and Treatment
- Sexual function and dysfunction studies
- Skin Protection and Aging
- Cancer and Skin Lesions
- Diet and metabolism studies
- Pharmacological Effects and Assays
- Gallbladder and Bile Duct Disorders
- Cutaneous Melanoma Detection and Management
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Doping in Sports
- Metabolism, Diabetes, and Cancer
- Folate and B Vitamins Research
- Peroxisome Proliferator-Activated Receptors
- Ovarian function and disorders
University Hospitals Birmingham NHS Foundation Trust
2018-2024
Brunel University of London
2018-2024
University Hospitals of North Midlands NHS Trust
2016-2024
University of Staffordshire
2016-2024
Keele University
2004-2024
NIHR Surgical Reconstruction and Microbiology Research Centre
2021-2023
University of Hull
2022
Good Hope Hospital
2007-2019
Heartlands Hospital
2016-2019
University of Warwick
2019
Background Low testosterone levels occur in over 40% of men with type 2 diabetes mellitus (T2DM) and have been associated increased mortality. Testosterone replacement together statins phosphodiesterase 5 inhibitors (PDE5I) are widely used T2DM. Purpose To determine the impact therapy (TRT) on mortality assess independence this effect by adjusting statistical models for statin PDE5I use. Methods We studied 857 T2DM screened from five primary care practices during April 2007–April 2009. Of...
To evaluate the sexual function response to 30 weeks' treatment with long-acting testosterone undecanoate (TU) or placebo in 199 men type 2 diabetes and either severe mild hypogonadism (HG).Men HG were identified from seven primary care registers. A 30-week randomized placebo-controlled study of TU was carried out these (placebo, n = 107, TU, 92). The patient-reported outcome measure 15-item International Index Erectile Function score. Men completing (n=189) stratified, firstly, by baseline...
Abstract Aims To describe changes in homeostasis model assessment of insulin resistance index (HOMA‐IR) following testosterone therapy men with hypogonadism and metabolic syndrome (MetS). Materials Methods A randomized, placebo‐controlled, double‐blind randomized controlled trial (RCT) comprising 184 MetS (testosterone undecanoate [TU]: 113 men, placebo: 71 men) was conducted. This followed by an open‐label phase which all were given TU. We focused on who not receiving antiglycaemic agents...
AIMTo determine how statins, testosterone (T) replacement therapy (TRT) and phosphodiesterase 5-inhibitors (PDE5I) influence age related mortality in diabetic men. METHODSWe studied 857 men screened for the BLAST study, stratifying them (mean follow-up = 3.8 years) into: (1) Normal T levels/untreated (total > 12 nmol/L free 0.25 nmol/L), Low T/untreated T/treated; (2) PDE5I/untreated PDE5I/treated; (3) statin/untreated statin/treated groups.The relationship between mortality, alone with...
Patients with basal cell carcinoma (BCC) demonstrate marked variation in clinical phenotype, suggesting the presence of distinct subgroups. truncal lesions comprise an interesting subgroup, because, although pathogenesis these tumors is unclear, there evidence to suggest that their development mediated by different mechanisms than mediate BCC on other sites. The authors now speculate some patients inherit a predisposition and develop disproportionately more this site patients.The studied 100...
AimsThe aim of this study was to determine whether growth differentiation factor-15 (GDF-15) predicts mortality and morbidity after cardiac resynchronization therapy (CRT). Growth factor-15, a transforming factor-β-related cytokine which is up-regulated in cardiomyocytes via multiple stress pathways, patients with heart failure treated pharmacologically.
To further characterize the beneficial impact of testosterone replacement therapy (TRT) on association between mortality and hypogonadism (HG) in men with type 2 diabetes (T2DM), by determining, firstly, if changes cardiovascular disease (CVD) risk factors after TRT play a role, secondly, whether reduction is lost when discontinued and, finally, presence subgroups where benefit may be greater.We studied 857 T2DM, screened for BLAST randomized controlled trial, over 3.8 years follow-up. The...
The clinico-pathological features of cardiac and pulmonary involvement were studied in seven cases fatal leptospirosis. Petechial haemorrhages occurred the heart pericardium all with blood-stained pericardial effusions five. Interstitial myocarditis was noted five patients probably caused changing electrocardiographic abnormalities clinical cardiovascular effects during illness. Sub-pleural intrapulmonary pleural four. Pulmonary oedema a striking feature early stages illness, while surviving...
Cutaneous basal cell carcinoma (BCC) risk is mediated by interactions between ultraviolet radiation (UVR) and host factors, including DNA repair efficiency. We investigated the association BCC SNPs in exon 6 (c.466C>A, dbSNP238406:g.C>A; designated C/A156), 10 (c.932G>A, dbSNP1799793:g.G>A; G/A312), 23 (c.2251A>C, dbSNP13181:g.A>C; A/C751) of nucleotide excision gene, XPD (ERCC2; cross-complementing deficiency, complementation 2 [xeroderma pigmentosum D]). genotype frequencies were not...
Ultraviolet radiation exposure increases basal cell carcinoma (BCC) risk, but may be protective against prostate cancer. We attempted to identify patterns that confer reduced cancer risk without increasing of BCC. used a questionnaire assess in 528 patients and 442 men with carcinoma, using 365 benign prostatic hypertrophy as controls. Skin type 1 (odds ratio (OR)=0.47, 95% CI=0.26-0.86), childhood sunburning (OR=0.38, CI=0.26-0.57), occasional/frequent sunbathing (OR=0.21, CI=0.14-0.31),...
The ever increasing interventional CVD outcome studies have resulted in statins being an essential factor of cardiovascular prevention strategies. JUPITER study 2008, despite reducing and overall mortality, highlighted increase new onset diabetes the rosuvastatin treated arm. Since then there been many meta-analyses RCTs largest carried out by Sattar et al showed a significant incidence during trials. findings from individual when comparing different were less clear. A higher statin dosage...
To describe the 4-year metabolic follow-up results from BLAST study. Baseline hemoglobin A1c (HbA1c), weight, and waist circumference (WC) data were recorded in 185 men recruited for randomised controlled trial (RCT) erectile function (EF) scores also available an additional 48 screened RCT. Intra/inter-group associations between these parameters testosterone replacement therapy (TRT) assessed at 1) end of RCT (30 weeks), 2) open-label phase (82 3) final assessment via non-parametric...
Introduction A number of guidance documents have been published in recent years for the diagnosis and management hypogonadism (HG). Laboratory practice has a major role supporting guidelines with accurate precise serum total testosterone (TT) methods standardised pre- post-analytical protocols. Our study investigated whether laboratory currently supports HG. Methods An internet-based questionnaire survey senior biochemists (UK/Republic Ireland) was conducted (April-May 2018). Questions...