A5010056437- Parkinson's Disease Mechanisms and Treatments
- Healthcare Decision-Making and Restraints
- Emergency and Acute Care Studies
- Folate and B Vitamins Research
- Intensive Care Unit Cognitive Disorders
- Cerebral Palsy and Movement Disorders
- Parkinson's Disease and Spinal Disorders
- Psychiatric care and mental health services
- Pregnancy and preeclampsia studies
- Long-Term Effects of COVID-19
- Fibroblast Growth Factor Research
- Dysphagia Assessment and Management
- Frailty in Older Adults
- Epigenetics and DNA Methylation
- Voice and Speech Disorders
- Dementia and Cognitive Impairment Research
- RNA regulation and disease
- Alcoholism and Thiamine Deficiency
- Vitamin D Research Studies
- Neurological Complications and Syndromes
- Kruppel-like factors research
- Pharmacological Effects and Toxicity Studies
University of Aberdeen
2019-2021
Newcastle University
2016-2019
Newcastle Hospitals - Campus for Ageing and Vitality
2016-2017
Royal Victoria Infirmary
2015-2016
Aberdeen Royal Infirmary
2013-2014
King's College London
2012
Abstract Introduction Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty unclear. Methods This multi-centre cohort study involved patients aged 18 years and hospitalised COVID-19, using routinely collected data. We used Cox regression analysis to assess impact age, delirium on risk inpatient mortality, adjusting for sex, illness severity, inflammation co-morbidities. ordinal logistic Clinical Frailty Scale (CFS)...
Previous cross-sectional studies have shown that Parkinson's disease (PD) patients lower serum 25-hydroxy vitamin D (25(OH)D) concentrations than controls. Vitamin deficiency was associated with increased severity and cognitive impairment in prevalent PD patients.
Background: Urate and homocysteine are potential biomarkers for disease progression in Parkinson's (PD).Baseline serum urate concentration has been shown to predict motor but not cognitive decline.The relationship between impairment is unknown.Objectives: The aim of this study was examine the association baseline homocysteine, prospective measures cognition over 54 months early PD.Methods: 154 newly diagnosed PD participants 99 age-matched controls completed a schedule assessments at...
To define the incidence, predictors and prognosis of first hospital delirium episode in Parkinson's disease (PD) atypical parkinsonism (AP), we identified after diagnosis Parkinsonism Incidence North-East Scotland (PINE) study, a prospective community-based incidence cohort parkinsonism, using chart-based criteria to delirium. Of 296 patients (189=PD, 107=AP [dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, vascular parkinsonism]), 152 developed (PD = 98,...
Nitrous oxide is commonly used as an analgesic and anaesthetic agent. also in use industry aerosol propellant now recognised a recreational drug whose growing, especially among the young. from whipped cream canisters inhaled to produce dissociative, intoxicated state. known inactivate vitamin B12 via oxidation, which can precipitate demyelinating myelopathy akin classical deficiency syndrome, subacute combined degeneration of spinal cord. This case describes young woman with chronic pain...
The Mental Capacity Act (2005) was designed to protect and empower patients with impaired capacity. Despite an estimated 40% of medical inpatients lacking capacity, it is unclear how many undergo capacity assessments treatment under the Act. We audited number on general wards English-teaching hospital. A total 95 sets case notes were reviewed: mean age 78.6 years, 57 female. most common presenting complaints feeling ‘unwell’ ( n = 25) confusion 24). In all, 52 had conditions, such as...
How to navigate the laws around capacity Patients require capacity, sufficient information, and freedom from coercion give consent medical investigation or treatment. Capacity is defined as mental ability make communicate a decision, it estimated that 26-40% of inpatients lack because illness, learning disability, condition affects brain function, such delirium head injury.123 Most countries have legal framework for assessing guiding decisions relating incapacitated people. In UK, there...
Background Postural instability and resultant fractures are common in parkinsonism but no studies have analysed fracture rates prospective incident cohorts of parkinsonian patients controls. Methods Data from the PINE study (326 patients, 261 age-gender matched controls) were used. The database included prospectively collected data on falls annual reviews supplemented by hospital GP records. Major defined as skull, long bone or pelvis. Kaplan-Meier curves for time-to-first diagnosis...
Research can be a difficult area for the novice to break into. A number of different obstacles face new researcher, starting with selecting suitable supervisor, writing workable protocol and obtaining permissions from all relevant organisations. This beginner's guide walks fledging researcher through required steps, including formulating research question, designing completing Integrated Application System form obtain permissions. The aim is demystify terms used in expose some pitfalls...