A5061371173- Virus-based gene therapy research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- RNA Research and Splicing
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Microbial infections and disease research
- Rabies epidemiology and control
- Oral microbiology and periodontitis research
- HIV/AIDS oral health manifestations
- Gut microbiota and health
- Cervical Cancer and HPV Research
- Yersinia bacterium, plague, ectoparasites research
- Herpesvirus Infections and Treatments
- RNA modifications and cancer
Konkuk University
2014-2023
Yale University
2021-2023
Kansas State University
2017-2020
The oral microbiome, which is closely associated with many diseases, and the resident pathogenic bacteria, can be transferred by close physical contact, are important public health considerations. Although dog most common companion animal, composition of canine may include human its relationship that their owners unclear. In this study, 16S rDNA pyrosequencing was used to compare microbiomes 10 dogs identify zoonotic pathogens. Pyrosequencing revealed 246 operational taxonomic units in...
Oral fluid analysis for herd monitoring is of interest to the commercial pig production in Korea.The aim this study was investigate pathogen-positive rates and correlations among eight pathogens associated with porcine respiratory disease complex by analyzing oral samples from 214 groups 56 farms.Samples collected a rope-chewing method underwent reverse-transcriptase polymerase chain reaction (RT-PCR) or standard (PCR) analysis, depending on microorganism.Pathogens were divided into virus...
Porcine Epidemic Diarrhea Virus (PEDV) is a coronavirus that infects the intestinal tract and causes diarrhea vomiting in older pigs or extreme dehydration death could reach 100% mortality neonatal piglets. In US, first PEDV outbreaks occurred 2013 since then US strains have quickly spread throughout worldwide, causing significant economic public health concerns. Currently two conditionally approved vaccines exist but there no live attenuated vaccine, which considered best option controlling...
Rottlerin (R) is a natural extract from Mallotus philippensis with antiviral properties. Feline infectious peritonitis (FIP) fatal disease caused by feline coronavirus (FCoV) that characterized systemic granulomatous inflammation and high mortality. We investigated the effect of liposome-loaded R, i.e., rottlerin-liposome (RL), against FCoV. demonstrated RL inhibited FCoV replication in dose-dependent manner, not only early endocytosis stage but also late replication. resolved low solubility...
The activity of proteins is thought to be invariably determined by their amino acid sequence or composition, but we show that a long segment viral protein can support infection independent its composition. During virus entry, the papillomavirus L2 capsid protrudes through endosome membrane into cytoplasm bind cellular factors such as retromer required for intracellular trafficking. Here, an ~110 predicted disordered and large deletions in this abolish infectivity HPV16 pseudoviruses...
Rottlerin(R) is a natural extract from Mallotus philippensis with antiviral properties. Feline Infectious Peritonitis (FIP) fatal disease characterized by systemic granulomatous inflammation and high mortality, no established prevention or cure. We investigated effect of liposome loaded R, Rottlerin-liposome(RL) against infectious peritonitis virus (FIPV), the causative agent. demonstrated that R RL inhibited FIPV replication in dose dependently PKCδ related manner, not only early...
Abstract The papillomavirus L2 capsid protein protrudes through the endosome membrane into cytoplasm during virus entry to bind cellular factors required for intracellular trafficking. Cytoplasmic protrusion of HPV16 L2, trafficking, and infectivity are inhibited by large deletions in an ∼110 amino acid segment that is predicted be disordered. activity these mutants can restored inserting segments with diverse compositions chemical properties this region, including scrambled sequences, a...