Symmetric dimethylarginine (SDMA) has been shown to be an accurate and precise biomarker for calculating estimated glomerular filtration rate (GFR) in humans, as well a more sensitive than serum creatinine concentration (sCr) assessing renal dysfunction.The purpose of this retrospective study was report on the utility measuring SDMA concentrations cats detection chronic kidney disease (CKD) before diagnosis by conventional measurement sCr.Chronic (n = 21) included those persistently azotemic...

Abstract Objective —To evaluate the effects of a food supplemented with fish oil omega-3 fatty acids on weight bearing in dogs osteoarthritis. Design —Randomized, double-blinded, controlled clinical trial. Animals —38 client-owned osteoarthritis examined at 2 university veterinary clinics. Procedures —Dogs were randomly assigned to receive typical commercial (n = 16) or test (22) containing 3.5% acids. On day 0 (before trial began) and days 45 90 after began, investigators conducted...

Serum concentrations of symmetric dimethylarginine (SDMA) detected chronic kidney disease (CKD) in cats an average 17.0 months before serum creatinine (Cr) increased above the reference interval.To report on utility measuring SDMA dogs for detection CKD diagnosis by measurement Cr.CKD (n = 19) included those persistently azotemic ≥3 5), that were at time death 4), and nonazotemic 10). compared with healthy control 20).Retrospective study, whereby Cr determined enzymatic colorimetry liquid...

Background Symmetric dimethylarginine ( SDMA ) is an accurate and precise biomarker for estimating glomerular filtration rate GFR in humans cats. Serum creatinine sC r) also correlates with , but has limitations as a of renal function because nonrenal factors can influence its concentration. Hypothesis Differences lean body mass LBM r, not serum concentrations. Animals Forty‐one healthy Beagles, mean age 9.9 years (range: 3.1–14.8 years), were studied over 6 month period. Methods biomarkers...

Abstract Objective —To assess the effect of food containing high concentrations fish oil omega-3 fatty acids and a low omega-6–omega-3 acid ratio on clinical signs osteoarthritis in dogs. Design —Randomized, double-blinded, controlled trial. Animals —127 client-owned dogs with 1 or more joints from 18 privately owned veterinary clinics. Procedures —Dogs were randomly assigned to be fed for 6 months typical commercial test 31-fold increase total content 34-fold decrease ratio, compared...

Abstract Objective: Obesity is a significant public health problem that affecting people and their pets. The human‐companion animal bond the role of pets in providing social support provides rationale framework for studying effectiveness combined (PP) exercising together (PPET) weight loss program. Research Methods Procedures: Thirty‐six pairs overweight or obese with an pet 56 only (PO) participated 1‐year prospective controlled study. In group format, received dietary physical activity...

Abstract Objective —To determine the effects of feeding a diet supplemented with fish oil omega-3 fatty acids on carprofen dosage in dogs osteoarthritis. Design —Randomized, controlled, multisite clinical trial. Animals —131 client-owned stable chronic osteoarthritis examined at 33 privately owned veterinary hospitals United States. Procedures —In all dogs, was standardized over 3-week period to approximately 4.4 mg/kg/d (2 mg/lb/d), PO. Dogs were then randomly assigned receive food or...

Dietary fiber is a key component in gastrointestinal health maintenance partly due to its fermentation by the gut microbiome. The food-dependent effects of novel bundle added hydrolyzed meat (HM) or grain-rich (GR) foods healthy dogs (n = 16) those with chronic enteritis/gastroenteritis were examined. Addition either food improved stool quality regardless status; microbiome diversity became more similar dogs. abundance bacteria mediating beneficial saccharolytic processes (eg,...

Background: Food supplemented with fish oil improves clinical signs and weight bearing in dogs osteoarthritis (OA). Objective: Determine whether increasing the amount of food provides additional symptomatic improvements OA. Animals: One hundred seventy-seven client-owned stable chronic OA hip or stifle. Methods: Prospective, randomized trial using pet dogs. Dogs were randomly assigned to receive baseline therapeutic (0.8% eicosopentanoic acid [EPA] + docosahexaenoic [DHA]) experimental foods...

Because animal studies are labor intensive, predictive equations used extensively for calculating metabolizable energy (ME) concentrations of dog and cat pet foods. The objective this retrospective review digestibility studies, which were conducted over a 7-year period based upon Association American Feed Control Officials (AAFCO) feeding protocols, was to compare the accuracy precision developed from these commonly equations. Feeding in dogs cats (331 227 respectively) showed that using...

Serum concentrations of symmetric dimethylarginine (SDMA) correlate with renal function in cats and SDMA has been shown to be a more reliable earlier marker for chronic kidney disease (CKD) compared serum creatinine (Cr). Calcium oxalate uroliths tend develop mid-to-older aged stones may cause reduction increased SDMA, but normal Cr. The purpose this retrospective study was determine if had concentrations, whether than concentrations. Cats the colony diagnosed between August 2010 December...

The optimal ranges of protein for healthy adult dogs are not known. This study evaluated the impact long-term consumption foods containing low, medium, and high levels on serum, urine, fecal metabolites, gut microbiome in beagles. Following maintenance a prefeed food 14 days, (15 neutered males, 15 spayed females, aged 2–9 years, mean initial weight 11.3 kg) consumed low (18.99%, dry matter basis), medium (25.34%), or (45.77%) foods, each 90 William’s Latin Square Design sequence. In serum...

The objective of this study was to determine the effect supplemental milk replacer on sow and litter performance. conducted in 12 farrowing groups (171 litters) over a 3.5-yr period (October 1990 April 1994). Commercial prepared fresh daily (150 g/L) offered with ad libitum access crates within 24 h parturition continued through weaning (d 21). Average pig weight (control, 5.5 kg/pig; supplemented, 6.4 P < .001) total 52.2 kg/litter; 60.9 at were greater for litters receiving replacer. There...

To assess effects of foods fortified with docosahexaenoic acid (DHA)-rich fish oil on cognitive, memory, psychomotor, immunologic, and retinal function other measures development in healthy puppies.Evaluation study.48 Beagle puppies.Puppies were assigned to 3 groups after weaning (n = 16/group) received 1 (low-DHA, moderate-DHA, or high-DHA food) as their sole source nutrition until year age. Visual discrimination learning memory tasks, psychomotor performance physiologic tests including...

A prospective study was conducted in client-owned geriatric cats to evaluate the short- term effects of a test food on serum symmetric dimethylarginine (SDMA) and creatinine (Cr) concentrations. Test contained functional lipids (fish oil), antioxidants (vitamins C E), L-carnitine, botanicals (vegetables), highly bioavailable protein, amino acid supplements. Cats (n = 80) were fed either or owner's-choice foods (non-nutritionally controlled cohort). included based age (≥ 9 years), indoor...

The objectives were to determine the effects of feeding different fiber types healthy cats and with chronic kidney disease (CKD) on plasma metabolites fecal microbiome. Methods A cross-over study within a split-plot design was performed using (n = 10) CKD [IRIS Stage 1 2; n 10]. Cats fed dry Prescription Diet® k/d® Feline chicken, during pre-trial period then randomly assigned two treatments for 4 weeks each. Treatment foods formulated similar food, exception that they contained 0.500%...

Abstract Alpha-tocopherol (vitamin E) is an antioxidant that largely involved in immune defense and enhancing the ability of biological systems to respond oxidative stress. During process free radical scavenging, vitamin C supports regeneration E. Although functions antioxidants their importance have been widely studied, intricate interplay between has yet be fully elucidated, especially dogs cats. As such, objective present study was determine effect a combination dietary on DNA damage...

Dogs and cats make short-term food choices based on palatability. We hypothesized that if palatability were masked, long-term would be physiologic requirements, circulating metabolite concentrations reflect those choices. Four experimental foods with similar palatability, but varying in macronutrient composition, prepared for healthy adult dogs (n=17) (n=27). Food 1 was high protein; 2 fat; 3 carbohydrates; 4 balanced macronutrients. By choosing any combination of foods, could individually...