A5102919208- Birth, Development, and Health
- Opioid Use Disorder Treatment
- Folate and B Vitamins Research
- Innovations in Medical Education
- Epigenetics and DNA Methylation
- Prenatal Substance Exposure Effects
- Food Security and Health in Diverse Populations
- Reproductive Biology and Fertility
- Child and Adolescent Health
- Reproductive tract infections research
- Mobile Health and mHealth Applications
- HIV/AIDS Research and Interventions
- Infant Development and Preterm Care
- Immunotherapy and Immune Responses
- Academic and Historical Perspectives in Psychology
- Genital Health and Disease
- Wireless Body Area Networks
- Electronic Health Records Systems
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Homelessness and Social Issues
- Substance Abuse Treatment and Outcomes
- Psychotherapy Techniques and Applications
- Obesity and Health Practices
- Immune Response and Inflammation
Montefiore Medical Center
2010-2021
Albert Einstein College of Medicine
2000-2021
Brown University
2019
ORCID
2019
University of Toronto
2013-2015
Montreal Neurological Institute and Hospital
2005-2006
Center for Children
2005
McGill University
2005
Families USA
2005
Nova Southeastern University
1994
Abstract The specific signals mediating the activation of microglia and astrocytes as a prelude to, or consequence of, CNS inflammation continue to be defined. We investigated TLRs novel receptors innate immune responses in human glial cells. find that express mRNA for 1–9, whereas robust TLR3, low-level TLR 1, 4, 5, 9, rare-to-undetectable 2, 6, 7, 8, 10 (quantitative real-time PCR). focused on 3 which can signal through both MyD88-dependent -independent pathways, MyD88-restricted TLR2. By...
<h3>Importance</h3> Treatment with methadone or buprenorphine is the current standard of care for opioid use disorder. Given paucity research identifying which patients will respond best to medication, both medications should be accessible all so that can determine works them. However, given differences in historical contexts their initial implementation, access each these may vary along racial/ethnic lines. <h3>Objective</h3> To examine extent capacity provide and measures segregation....
Reactive oxygen species (ROS) are implicated in fetal alcohol spectrum disorders (FASD) caused by (ethanol, EtOH). Although catalase detoxifies hydrogen peroxide, embryonic activity is only about 5% of maternal levels. To determine the roles ROS and FASD, pregnant mice with enhanced (expressing human catalase, hCat) or deficient (acatalasemic, aCat) activity, their respective wild-type (WT) controls, were treated ip on gestational day 9 4 6g/kg EtOH its saline vehicle, embryos fetuses were,...
The breast cancer 1 (brca1) gene is associated with and ovarian cancers, heterozygous (+/-) brca1 knockout progeny develop normally, suggesting a negligible developmental impact. However, our results show BRCA1 plays broader biological role in protecting the embryo from oxidative stress. Sox2-promoted Cre-expressing hemizygous males were mated floxed females, gestational day 8 +/- conditional embryos 28% reduction protein expression exposed culture to reactive oxygen species (ROS)-initiating...
A proportion of patients with multiple sclerosis (MS) receiving systemic interferon beta therapy will develop serum neutralizing antibodies (NAbs) that can reduce the activity drug. Interferon-beta (IFN-beta) is produced by glial cells within central nervous system. Although does not access system, titers NAbs may be sufficient some system.To address whether samples contain high could inhibit cell production chemokines and cytokines are regulated endogenous IFN-beta.We used an in vitro assay...
Abstract: Physicians who want to prescribe buprenorphine treat opioid use disorder require a waiver established by the Drug Addiction Treatment Act (DATA) of 2000, often through completion an eight-hour training course. This is issue for number reasons, including that overdose deaths continue rise nationally. However, on October 24, 2018, SUPPORT (Substance Use-Disorder Prevention Promotes Opioid Recovery and Treatment) Patients Communities was signed into law. bill allows any physician...