A5085607731- Cholangiocarcinoma and Gallbladder Cancer Studies
- Muscle metabolism and nutrition
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Clinical Nutrition and Gastroenterology
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Nutrition and Health in Aging
- Viral-associated cancers and disorders
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Animal Nutrition and Health
- Vitamin C and Antioxidants Research
- Gastrointestinal disorders and treatments
- Reproductive Physiology in Livestock
- Trace Elements in Health
- Cannabis and Cannabinoid Research
- Extracellular vesicles in disease
- Selenium in Biological Systems
- Burn Injury Management and Outcomes
- Cancer, Hypoxia, and Metabolism
Shanghai Jiao Tong University
2025
Tongren Hospital
2025
Chinese Center For Disease Control and Prevention
2025
National Health and Family Planning Commission
2020-2023
Second Affiliated Hospital of Zhejiang University
2023
First Affiliated Hospital Zhejiang University
2019-2021
Zhejiang University
2019-2020
Police General Hospital
1990
Abstract Exosomes play an important role in intercellular communication and metastatic progression of hepatocellular carcinoma (HCC). However, cellular between heterogeneous HCC cells with different potentials the resultant cancer are not fully understood HCC. Here, high-metastatic capacity (97hm Huhm) were constructed by continually exerting selective pressure on primary (MHCC-97H Huh7). Through performing exosomal miRNA sequencing 97hm), many significantly candidates found. Among these...
Abstract Hepatocellular carcinoma (HCC) is a highly heterogeneous, multigene-driven malignant tumor. Long chain acyl-CoA synthetase 4 (ACSL4), an enzyme has pivotal roles in arachidonic acid (AA) metabolism. However, its function and the underlying molecular mechanisms HCC are still not fully elucidated. Here, we identified ACSL4 as novel marker for AFP high subtype through transcriptome profiling. was frequently upregulated samples associated with poor prognosis. Functionally, knockdown...
Despite the high efficacy of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) in treating acute promyelocytic leukemia (APL), approximately 10-20% patients develop drug resistance due to mutations PML-RARα other factors. Here, it is demonstrated that inhibiting USP2 with ML364 or silencing reduces protein levels both ATRA-sensitive -resistant APL cells, an effect reversed by proteasome inhibition. Conversely, overexpression enhances stability. Mechanistically, interacts...
Background: Hepatocellular carcinomas (HCC) constantly rank among the malignancies with highest death tolls on global scale.Moreover, HCC are associated a limited set of therapeutic options.This is particularly true in case advanced stage cancers, where long-term survival uncommon.For inoperable, patients, chemotherapy main modality treatment.Due to lack known molecular targets, efficacy limited.Conclusion: These findings clearly indicate that DNA methylation plays key role regulating ACADS...
Background Although protein supplementation may be desirable in the management of sarcopenia, appropriate requirements for older adults with sarcopenia are presently unclear. Objective The aim this study was to determine (65–81 year) by using indicator amino acid oxidation (IAAO) technology. Methods Nine (four male participants and five female participants) participated study, intakes ranging from 0.1 1.8 g/(kg·d). Each participant consumed an adapted diet a level 1.0 g/(kg·d) 1.7 resting...
Inhibiting ferroptosis represents a promising strategy to combat ferroptosis-related diseases. Here we show that 428, selenide-containing noscapine derivative, effectively inhibits in various cell lines by enhancing the stability and activity of GPX4. TRIM41 was identified as novel E3 ubiquitin ligase GPX4 428 demonstrated bind selenocysteine residue Sec46 via formation transient reversible Se-Se bond, thereby blocking interaction between TRIM41, stabilizing its activity. This unique dynamic...
Objectives: Although some studies have assessed Selenium nutritional status in different populations, determining the plasma levels and describing distribution of dietary intake Chinese female adults by using nationally representative data was lacking. The objective to describe plasma/dietary analyze possible influencing factors related levels. Method: A total 3016 from China Nutrition Health Surveillance 2015 (CNHS 2015) were included. concentration detected inductively coupled mass...
To assess the status of vitamin K(VK) dietary intake in healthy Chinese middle-aged and elderly population. The population sample was extracted from Adult Chronic Disease Nutrition Surveillance(CACDNS) 2015-2017. A total 1409 subjects were enrolled after screening. Food frequency questionnaire used to investigate data, VK food composition database(including VK_1, MK-4, MK-7 MK-9) established by "China Composition Database" team updated for analysis intake. We calculated various subtypes...
Methylation landscape is important for maintaining the silence of cannabinoid receptor-interacting protein 1 (CNRIP1) in some tumors. However, role CNRIP1 intrahepatic cholangiocarcinoma (ICC) remains poorly defined.In our study, we showed that was down-regulated ICC tissues, and low expression significantly associated with poor prognosis patients 3-year overall survival tumor-free survival. Investigating genomic DNA methylation profile, disclosed a CpG island site named MS-2 (CNRIP1 site-2)...
Cholangiocarcinoma (CCA) is a subtype of highly malignant hepatic tumor, which has low 5-year survival rate and poor clinical outcome. Only few patients can be detected early accepted with the surgery. Most CCA are diagnosed in advanced stage, treatments limited. As for inoperable, patients, chemotherapy main treatment, due to lacking molecular targets, therapeutic effect limited.To explore potential targets CCA, we analyzed three microarray datasets derived from Gene Expression Omnibus...
Abstract It is now generally believed that elderly may have slightly higher dietary protein requirements than those of the young-middle-aged adults. We previously conducted related studies by indicator amino acid oxidation (IAAO) technique, but more research data are needed to revise elderly. The main objective was reevaluate healthy Chinese adults (65–80 years) without sarcopenia using IAAO technique. Nine adult men and seven women participated in study, with intakes ranging from 0·1 1·8...
Abstract: Heterotopic pancreas (HP) is a developmental anomaly defined as aberrantly located pancreatic tissue with no anatomical, vascular, or neural connection to the pancreas. Bowel intussusception and gastrointestinal bleeding caused by isolated HP extremely rare. This study explores clinical, radiographical, pathologic, treatment features of four patients incidental HP, aim providing important insight into diagnosis management these patients. In this paper, charts who underwent...
To evaluate the changes in protein requirements of elderly during past five years.
Abstract Goals: We aim to draw a conclusion which side of hepatectomy could be the priority for hilar cholangiocarcinoma patients. Background: Surgery is established as only potentially curative treatment cholangiocarcinoma. However, whether should preferred left-side hepatectomy, contains left hemihepatectomy, extended hemihepatectomy and trisectionectomy, or right-side represents right debated. In this meta-analysis, we evaluated compared efficacy safety in patients with Study:...
Abstract Goals: We aim to draw a conclusion which type of hepatectomy could be the priority for hilar cholangiocarcinoma patients. Background: Surgery is established as only potentially curative treatment cholangiocarcinoma. However, whether should preferred left-side hepatectomy, includes left hemihepatectomy, extended hemihepatectomy and trisectionectomy, or right-side represents right debated. In this meta-analysis, we evaluated compared efficacy safety in patients with Study:...
Accurate and continuous blood pressure (BP) monitoring is essential to the early prevention of cardiovascular diseases. Non-invasive cuff-less BP estimation algorithm has gained much attention in recent years. Previous studies have demonstrated that brain bio-impedance (BIOZ) a promising technique for non-invasive intracranial (ICP) monitoring. Clinically, treatment patients with traumatic injuries (TBI) requires ICP simultaneously. Estimating by BIOZ directly can reduce number sensors...