A5016344857- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- Spinal Fractures and Fixation Techniques
- Orthopedic Surgery and Rehabilitation
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Bone fractures and treatments
- Musculoskeletal pain and rehabilitation
- Cell death mechanisms and regulation
- Rheumatoid Arthritis Research and Therapies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cervical and Thoracic Myelopathy
- Chemokine receptors and signaling
- Atherosclerosis and Cardiovascular Diseases
- Tendon Structure and Treatment
- Blood properties and coagulation
- Pelvic and Acetabular Injuries
- Pregnancy-related medical research
- Elbow and Forearm Trauma Treatment
- Cancer Mechanisms and Therapy
Bam University of Medical Sciences
2022-2024
Shiraz University of Medical Sciences
2020-2022
In the article presented herein, a deoxyribonucleic acid (DNA) biosensor is introduced for Vincristine determination in pharmaceutical preparations based on modification of screen printed electrode (SPE) with double-stranded DNA (ds-DNA), polypyrrole (PP), peony-like CuO:Tb 3+ nanostructure (P-L NS). The developed sensor indicated wide linear response to concentration ranged from 1.0 nM 400.0 μM limit detection as low .21 nM. intercalation guanine led response. optimized parameters...
Cardiomyocyte differentiation is a complex process that follows the progression of gene expression alterations. The ErbB signaling pathway necessary for various stages cardiac development. We aimed to identify potential microRNAs targeting genes by in silico approaches. Small RNA-sequencing data were obtained from GSE108021 cardiomyocyte differentiation. Differentially expressed miRNAs acquired via DESeq2 package. Signaling pathways and ontology processes identified determined targeted those...
Osteoarthritis (OA) is one of the principal causes chronic joint disease with a series pathological features. The present study aimed to identify key microRNAs (miRNAs) and signaling pathways in OA biological fluids explain potential mechanisms underlying introduce biomarkers using computational analysis. Differentially expressed (DEmiRNAs) serum, plasma, synovial patients were identified GEO2R, limma, DESeq2 packages R software based on dataset from GSE151341, GSE105027, GSE126677. gene...
Background: Osteoarthritis is one of the principal causes chronic joint disease and may progressively engender disability in elderly individuals. The present study aimed to identify differentially expressed genes associated signaling pathways end-stage osteoarthritis. Methods: Differentially messenger RNAs early end stages osteoarthritis were examined through gene expression omnibus 2R (GEO2R) GSE32317 dataset. Subsequently, ontology (GO) enrichment, Kyoto Encyclopedia Genes Genomes (KEGG),...
Intervertebral disc degeneration (IDD) is widely known as the principal cause of low back pain, diminishing patients' quality life and imposing a huge economic burden on healthcare systems worldwide. However, underlying mechanisms IDD remain to be determined. This study aimed scrutinize data sets via bioinformatics identify microRNAs (miRNAs)/genes pathways associated with IDD. The array profiling patients individuals without was acquired from Gene Expression Omnibus (GEO) database (viz.,...
Carpal tunnel syndrome (CTS) is a common disease resulting from the median nerve entrapment at wrist. Although CTS (prevalence=5%-10% in general population) most neuropathy, its molecular mechanisms need elucidation. We used bioinformatics to detect genes with differential expressions and introduce regulatory noncoding RNAs signaling pathways involved.
Osteoarthritis (OA) and rheumatoid arthritis (RA) treatment requires exact type diagnosis. We compared inflammatory molecular mechanisms between OA RA to introduce reliable biomarkers. The GSE55235 GSE100786 microarray datasets were acquired from the GEO. Data preprocessing differential expression analysis conducted in groups their control applying GEO2R. Differentially expressed genes (DEGs) with a |LogFC|>1 adj.
Cadaver study.To investigate the risk of L5 nerve injury following sacral ala decortication performed during lumbosacral posterolateral fusion surgery.Fourteen fresh cadaver pelvises were dissected through an anterior approach and nerves on both sides explored macroscopically examined by direct observation. Then, corticotomy was at 0°, 20°, 30° angles to sagittal plane posterior approach. The site checked each side its distance root measured.The tip osteotome in danger zone (5 mm medial 5...
Background: Intervertebral disc degeneration (IDD) is a common disability in the working-age population. The underlying pathogenesis of IDD needs elucidation. This study aimed to determine differentially expressed circular RNAs (circRNAs) by bioinformatics. Additionally, environmental and clinical factors involved were reviewed. Methods: circRNA array profiling patients with healthy individuals (GSE67566) was acquired from Gene Expression Omnibus (GEO). GEO2R employed analyze expression...
Traumatic cervical translational injury is a notably rare and highly unstable subtype of type C sub-axial spine with high morbidity mortality rates. Hereby, we report 41-years-old man who was case multiple trauma due to car rollover. He completely conscious, complaining pain, GCS score 15/15. His neurological examination unremarkable. The CT scan revealed vertical translation at the C6-C7 level (roughly 11 mm) bilateral facet joint diastases which are injuries. A two-stage combined anterior...
Background: We investigated the expression pattern of a human stem cell-specific, large intergenic noncoding RNA (lincRNA) regulator reprogramming (lincRNA-ROR) and its spliced transcript variants in breast tumors. Breast cancer is leading cause mortality women; therefore, finding reliable diagnostic tumor marker, based on molecular profile cells, warranted. Methods: qRT-PCR was used to investigate alteration specific cell-related lincRNA tumors which provided by Iran National Tumor Bank...
Plastic deformities usually occur in skeletally immature bones not completely ossified due to longitudinal forces on their distal ends, especially the forearm and lower legs. Pediatric lateral humeral condylar fractures (LHCFs) constitute second most common intra-articular fracture upper extremity. Nevertheless, plastic accompanied by other traumatic injuries, including LHCFs, are atypical rare. This study presents an exceedingly rare case of concurrence a deformity ipsilateral condyle...