A5039103241- Protease and Inhibitor Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Nutrition and Health in Aging
- Chemokine receptors and signaling
- Nutrition, Genetics, and Disease
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer survivorship and care
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Cancer Risks and Factors
- S100 Proteins and Annexins
- Galectins and Cancer Biology
- Cardiovascular Disease and Adiposity
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Angiogenesis and VEGF in Cancer
- Metabolism, Diabetes, and Cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
Istituto Tumori Bari
2010-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2021
Cancer has become a serious problem worldwide, as it represents the main cause of death, and its incidence increased over years. A potential strategy to counter growing spread various forms cancer is adoption prevention strategies, in particular, use healthy lifestyles, such maintaining weight, following diet; being physically active; avoiding smoking, alcohol consumption, sun exposure; vitamin D supplementation. These modifiable risk factors are associated with this disease, contributing...
Abstract Although relatively good therapeutic results are achieved in non‐advanced cancer, the prognosis of advanced colon cancer still remains poor, dependent on local or distant recurrence disease. One factors responsible for is supposed to be stem cells (CSCs) tumor‐initiating cells, which a population with ability perpetuate themselves through self‐renewal and generate differentiated thought tumor recurrence. This study globally approach possible role tissue‐derived initiation its...
The standard treatment for advanced hepatocellular carcinoma (HCC) is sorafenib, a multikinase inhibitor of tumor cell proliferation and angiogenesis. Hyperthermia inhibits angiogenesis promotes apoptosis. Potential synergic antiangiogenic proapoptotic effects represent the rationale combining sorafenib with electro‑hyperthermia (EHY) in HCC. A total 21 patients (median age, 64 years; range, 55‑73 years) HCC were enrolled current study between February 2009 September 2010. EHY was achieved...
Colorectal cancer is the most common of gastrointestinal system and has a marked preference to metastasize distant organs. In this study, we investigated whether levels circulating serum pro-angiogenic cytokine such as chemokine (C-X-C motif) ligand 1 (melanoma growth-stimulating activity, alpha; CXCL1) vascular endothelial growth factor (VEGF) have role in favoring colonization metastatic cells at preferential sites determined their prognostic significance cohort 103 patients with...
Background/Aim: Colorectal Cancer is the fourth most frequent cause of cancer death worldwide and its incidence increases from 50 years age. It often associated with protein-caloric malnutrition 20% deaths occur due to this event. The aim study was assess prevalence inflammatory status in 78 patients undergoing surgery for colorectal carcinoma. Patients Methods: Nutritional Status assessed by Mini Assessment (MNA). Serum levels interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α) were...
The epidermal growth factor receptor (EGFR) is a member of family cell membrane receptors that use tyrosine kinase activity as the signal transduction mechanism. It commonly expressed or overexpressed by many solid tumors and correlates with disease progression poor clinical prognosis. Increased EGFR expression might therefore be strong prognostic feature in multiple tumor types, inhibition its cellular actions may have substantial therapeutic benefit. aim this study was to estimate serum...
Although several molecular markers have been proposed as prognostic of disease progression in Hepatocellular carcinoma (HCC), predictive response to treatment are still unsatisfactory. Here, we propose a genetic polymorphism potential factor poor prognosis HCC patients treated with transcatheter arterial chemoembolization (TACE). In particular, show that the guanosine insertion/deletion promoter region SERPINE1 gene at − 675 bp position, named 4G/4G, predicts cohort 75 undergoing TACE. By...
Background: ADIPOQ gene, which encode for Adiponectin (APN), is sited on chromosome 3q27 and linked to a susceptibility locus metabolic syndrome (MetS).The rs266729 G/C gene polymorphism significantly associated with low APN levels develop cancer.In addition, decreased serum are tumor development progression inversely markers of inflammation.Here, we investigate the influence adipocytokine circulating their association MetS in colorectal cancer patients (CRC).Methods: Blood samples from 105...