A5064081729- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Neural Engineering
- Vagus Nerve Stimulation Research
- Advanced Materials and Mechanics
- EEG and Brain-Computer Interfaces
- Electrochemical sensors and biosensors
- Analytical Chemistry and Sensors
- Structural Analysis and Optimization
- Electrochemical Analysis and Applications
- Tactile and Sensory Interactions
- Conducting polymers and applications
- Lipid Membrane Structure and Behavior
- Wireless Power Transfer Systems
- Veterinary Pharmacology and Anesthesia
- Exercise and Physiological Responses
- Non-Invasive Vital Sign Monitoring
- Advanced Memory and Neural Computing
- Surface Modification and Superhydrophobicity
- Microfluidic and Capillary Electrophoresis Applications
- Modular Robots and Swarm Intelligence
- Electrospun Nanofibers in Biomedical Applications
- Adhesion, Friction, and Surface Interactions
- Advancements in Transdermal Drug Delivery
- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
Purdue University West Lafayette
2019-2025
Korea Advanced Institute of Science and Technology
2017
Abstract For legged robots, collecting tactile information is essential for stable posture and efficient gait. However, mounting sensors on small robots weighing less than 1 kg remain challenges in terms of the sensor’s durability, flexibility, sensitivity, size. Crack-based featuring ultra-sensitivity, small-size, flexibility could be a promising candidate, but performance degradation due to crack growing by repeated use stumbling block. This paper presents an ultra-stable tough...
Self-healing hydrogels are in high demand for wearable sensing applications due to their remarkable deformability, ionic and electrical conductivity, self-adhesiveness human skin, as well resilience both mechanical damage. However, these face challenges such delayed healing times unavoidable hysteresis, which limit practical effectiveness. Here, we introduce a self-healing hydrogel that exhibits exceptionally rapid with recovery time of less than 0.12 s an ultralow hysteresis 0.64% under...
Continuous real-time monitoring of biomarkers in interstitial fluid is essential for tracking metabolic changes and facilitating the early detection management chronic diseases such as diabetes. However, developing minimally invasive sensors situ analysis addressing signal delays remain a challenge. Here, we introduce wearable sensor patch incorporating hydrogel microneedles rapid, collection from skin while simultaneously measuring biomarker levels situ. The stretchable to accommodate...
Abstract The vagus nerve (VN) plays an important role in regulating physiological conditions the gastrointestinal (GI) tract by communicating via parasympathetic pathway to enteric nervous system (ENS). However, lack of knowledge neurophysiology VN and GI limits development advanced treatments for autonomic dysfunctions related VN. To better understand complicated underlying mechanisms VN-GI neurophysiology, it is necessary use device enabled microfabrication technologies. Among several...
Glutamate, one of the main neurotransmitters in brain, plays a critical role communication between neurons, neuronal development, and various neurological disorders. Extracellular measurement such as glutamate brain is important for understanding these processes developing new generation brain–machine interfaces. Here, we demonstrate use perovskite nickelate–Nafion heterostructure promising sensor with low detection limit 16 nM response time 1.2 s via amperometric sensing. We have designed...
Vagus nerve stimulation (VNS) is a recognized treatment for neurological disorders, yet the surgical procedure carries significant risks. During process of isolating or cuffing vagus nerve, there danger damaging itself adjacent carotid artery jugular vein. To minimize this risk, here we introduce novel hydrogel adhesive-integrated and stretchable microdevice that provides less invasive, cuff-free option interfacing with nerve. The device features adhesive formulation enables crosslinking on...
Smart, ultrascaled, always-on wearable (and implantable) sensors are an exciting frontier of modern medicine. Among them, minimally invasive microneedles (MN) emerging technology platform for theragnostic applications. Compared to traditional continuous glucose measurement (CGM) devices, these MNs offer painless insertion and simple operation. These MN systems, however, rely on analyte diffusion from the interstitial fluid (ISF) sensing site, thus, 1) introduce a substantial intrinsic delay...
Here we demonstrate a simple and scalable nanotexturing method for both planar (films) nonplanar (tubes) polytetrafluoroethylene (PTFE) surfaces using commercial desktop oxygen plasma etcher. The process can generate semiordered nanopillar structures on tubular samples with high radial axial uniformity. We found that the resulting exhibit good in vitro bactericidal vivo anti-inflammatory properties. When tested against Staphylococcus aureus, nanotextured showed significantly decreased live...
Abstract Vagus nerve stimulation (VNS) has the potential to treat various peripheral dysfunctions, but traditional cuff electrodes for VNS are susceptible off‐target effects. Microelectrodes may enable highly selective that can mitigate effects, they suffer from increased impedance. Recent studies on microelectrodes with non‐Euclidean geometries have reported higher energy efficiency in neural applications. These previous use mm/cm‐scale dimensions, mostly targeted myelinated fibers. This...
Opioid-induced overdose is one of the leading causes death among US population under age 50. In 2021 alone, toll opioid users rose to a devastating number over 80,000. The process can be reversed by administration naloxone, an antagonist that rapidly counteracts effects opioid-induced respiratory depression. idea closed-loop detection and naloxone delivery has emerged as potential engineered solution mitigate deadly epidemic. this work, we introduce wrist-worn wearable device overcomes...
Abstract In this paper, a novel strategy to control the orientation of nanowrinkles by applying thickness‐gradient bilayer‐system is presented. Surface modification plasma treatment on ultraviolet light‐curable polysiloxane‐based resin applies biaxial compressive strain, resulting in formation randomly oriented over large‐area. The resin, given meniscus formed between groove made with patterned polydimethylsiloxane (PDMS) after spin‐coating directed wrinkle propagation. Given propagation...
Background and Hypothesis:Approximately 16% of the American population suffers from overactive bladder, with 25-40% patients reporting unsatisfactory results following first line treatments. Sacral neuromodulation is a well-established, minimally invasive treatment option for several forms bladder bowel dysfunction that are non-responsive to pharmacologic or behavioral therapies. While more broadly applicable stimulus parameters being investigated, precise set nerve fibers whose activity...
Soft, stretchable design can improve long-term stability of neural interface devices.Here we present our latest efforts to design, fabricate and evaluate thin-film cuff electrode devices for vagus nerve stimulation, which have Y-shaped kirigami microstructures.We fabricated Y-microstructured thinfilm electrodes by using conventional photolithography reactive ion etching.The monolithic device enables easier transfer a different substrate without having use the traditional PDMS-stamp-based...
Vagus nerve stimulation (VNS) is a moderately effective treatment option for intractable epilepsy, depression, and pain, with promising applications in the of gastrointestinal motility disorders like gastroparesis. The wide-ranging potential indications VNS suggest an opportunity better understanding underlying neural circuits that can be targeted using microscale electrodes. However, Platinum (Pt) electrodes often have limited charge injection capacity due to their high impedance. Recently,...