A5008384468- Xenotransplantation and immune response
- 3D Printing in Biomedical Research
- Advanced Sensor and Energy Harvesting Materials
- Pneumocystis jirovecii pneumonia detection and treatment
- Mesenchymal stem cell research
- Organ and Tissue Transplantation Research
- Pluripotent Stem Cells Research
- Tactile and Sensory Interactions
- Tuberculosis Research and Epidemiology
- Tissue Engineering and Regenerative Medicine
- Corneal Surgery and Treatments
- Nanomaterials and Printing Technologies
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Advanced Materials and Mechanics
- Reproductive System and Pregnancy
- Retinal Diseases and Treatments
- Pneumonia and Respiratory Infections
- Parasites and Host Interactions
- Single-cell and spatial transcriptomics
- Liver physiology and pathology
- Ocular Surface and Contact Lens
Purdue University West Lafayette
2024
Indiana University School of Medicine
2018-2023
Indiana University – Purdue University Indianapolis
2020-2023
Rose–Hulman Institute of Technology
2022
Indiana University
2018
St Mary's Hospital
2005
Self-healing hydrogels are in high demand for wearable sensing applications due to their remarkable deformability, ionic and electrical conductivity, self-adhesiveness human skin, as well resilience both mechanical damage. However, these face challenges such delayed healing times unavoidable hysteresis, which limit practical effectiveness. Here, we introduce a self-healing hydrogel that exhibits exceptionally rapid with recovery time of less than 0.12 s an ultralow hysteresis 0.64% under...
Natural killer (NK) cells play an important role in immune rejection solid organ transplantation. To mitigate human NK cell activation xenotransplantation, introducing inhibitory ligands on xenografts via genetic engineering of pigs may protect the graft from cell-mediated cytotoxicity and ultimately improve xenograft survival. In this study, non-classical HLA class I molecules HLA-E HLA-G were introduced immortalized porcine liver endothelial line with disruption five genes ( GGTA1 , CMAH...
Strain gauges, particularly for wearable sensing applications, require a high degree of stretchability, softness, sensitivity, selectivity, and linearity. They must also steer clear challenges such as mechanical electrical hysteresis, overshoot behavior, slow response/recovery times. However, current strain gauges face in satisfying all these requirements at once due to the inevitable trade-offs between properties. Here, we present an innovative method creating from spongy Ag foam through...
Xenotransplantation (cross-species transplantation) using genetically-engineered pig organs offers a potential solution to address persistent organ shortage. Current evaluation of porcine genetic modifications is monitor the nonhuman primate immune response and survival after xenotransplantation. This measure an essential step before clinical xenotransplantation trials, but it time-consuming, costly, inefficient with many variables. We developed efficient approach quickly examine...
Abstract Persistent and saturated oxygen distribution from perfusion media (i.e., blood, or cell culture media) to cells within cell-dense, metabolically-active biofabricated tissues is required keep them viable. Improper poor supply the tissue bulk severely limits culturing potential of many bioreactors. We added an oxygenator module our modular FABRICA bioreactor in order provide stable oxygenation during culture. In this proof concept study oxygenated perfused bioreactor, we characterized...
Intravital microscopy studies of LysM-EGFP mice demonstrate that abdominal imaging windows placed over the kidney stimulated a variety changes consistent with foreign body response. Within day implantation, leukocytes were recruited to window where, next 16 days, they increased in number an expanding volume developed new vascular network. These accompanied by dramatic increase glomerular permeability albumin.
Background and Hypothesis: Hepatic stellate cells (HSC), which compromise ~15% of liver cells, are vital to hepatocellular function. Scaffold-free 3D-bioprinting (SF3DBP) offers an avenue for the creation realistic organ models without use biomaterials. Therefore, we hypothesized that co-culturing primary hepatocytes with HSC in SF3DBP model would uphold hepatocyte function over time, providing us a better 3D-liver research. 
 Experimental Design: We used freshly thawed pig immortalized...
Introduction: Natural killer (NK) cells play an important role in immune rejection solid organ transplantation. Introducing inhibitory ligands on xenografts via genetic engineering may mitigate human xenoreactive NK cell activation and improve xenograft survival. such as non-classical leukocyte antigens (HLA)-E -G are highly expressed the placenta contribute to establishing maintaining tolerance at maternal-fetal interface. HLA-E or HLA-G porcine attenuate distinct inhibition pathways have...