A5021151324- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Liver physiology and pathology
- Various Chemistry Research Topics
- Innovative Teaching Methods
Indiana University School of Medicine
2018-2020
Indiana University – Purdue University Indianapolis
2020
Indiana University
2018
Butler University
2016
Abstract Persistent and saturated oxygen distribution from perfusion media (i.e., blood, or cell culture media) to cells within cell-dense, metabolically-active biofabricated tissues is required keep them viable. Improper poor supply the tissue bulk severely limits culturing potential of many bioreactors. We added an oxygenator module our modular FABRICA bioreactor in order provide stable oxygenation during culture. In this proof concept study oxygenated perfused bioreactor, we characterized...
This article presents a series of Proteopedia pages about the structure and function five G-protein coupled receptors (GPCRs). GPCRs are responsible for roughly 80% cellular signal transduction targets over 40% approved therapeutic agents. Until recently, structural knowledge has, however, lagged behind their biological understanding. Yet with experimental advancements, GPCR structures now available across families, in different conformations, various signaling partners. In five-linked...
Background and Hypothesis: Hepatic stellate cells (HSC), which compromise ~15% of liver cells, are vital to hepatocellular function. Scaffold-free 3D-bioprinting (SF3DBP) offers an avenue for the creation realistic organ models without use biomaterials. Therefore, we hypothesized that co-culturing primary hepatocytes with HSC in SF3DBP model would uphold hepatocyte function over time, providing us a better 3D-liver research. 
 Experimental Design: We used freshly thawed pig immortalized...