A5023650979- Bone health and osteoporosis research
- Connective tissue disorders research
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Bone Metabolism and Diseases
- Bone fractures and treatments
- Bone health and treatments
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Musculoskeletal pain and rehabilitation
- Connexins and lens biology
- Down syndrome and intellectual disability research
- Estrogen and related hormone effects
- Pregnancy-related medical research
- TGF-β signaling in diseases
- Cardiomyopathy and Myosin Studies
- Adipose Tissue and Metabolism
- Genetics and Physical Performance
- Genomics and Chromatin Dynamics
- Heat shock proteins research
- Thermoregulation and physiological responses
- Bone Tissue Engineering Materials
- Cardiovascular Function and Risk Factors
- RNA Research and Splicing
- Parathyroid Disorders and Treatments
Cook Biotech (United States)
2024
Purdue University West Lafayette
2017-2022
University of Indianapolis
2015-2016
Indiana University – Purdue University Indianapolis
2015-2016
University of Kentucky
2016
Strain-induced adaption of bone has been well-studied in an axial loading model the mouse tibia. However, most outcomes these studies are restricted to changes architecture and do not explore mechanical implications those changes. Herein, we studied both morphological adaptions three strain levels using a targeted tibial model. We hypothesized that would increase improve cortical properties dose-dependent fashion. The right tibiae female C57BL/6 mice (8 week old) were compressively loaded...
Abstract Abdominal aortic aneurysm (AAA) formation and expansion is highly complex multifactorial, the improvement of animal models an important step to enhance our understanding AAA pathophysiology. In this study, we explore ability influence growth in a topical elastase plus β-Aminopropionitrile (BAPN) mouse model by varying concentration altering cross-linking capability tissue. To do so, assess both chronic acute effects using volumetric ultrasound. Our results suggest that applied...
Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is characterized a spectrum phenotypes including skeletal abnormalities. The Ts65Dn DS mouse model exhibits similar as humans with DS. DYRK1A, kinase encoded on Hsa21, has been linked to deficiencies in bone homeostasis mice and individuals Treatment Epigallocatechin-3-gallate (EGCG), known inhibitor Dyrk1a, improves some abnormalities associated mice. EGCG supplements are widely available but the effectiveness different...
In vivo imaging has provided a unique framework for studying pathological progression in various mouse models of cardiac disease. Although conventional short-axis motion-mode (SAX MM) ultrasound and cine magnetic resonance (MRI) are two the most prevalent strategies used quantifying function, there few notable limitations including imprecision, inaccuracy, geometric assumptions with ultrasound, or large costly systems substantial infrastructure requirements MRI. Here we present an automated...
Abstract Tissue engineered vascular grafts (TEVGs) using scaffolds fabricated from braided poly(glycolic acid) (PGA) fibers coated with poly(glycerol sebacate) (PGS) are developed. The approach relies on in vivo tissue engineering by which neotissue forms solely within the body after a scaffold has been implanted. Herein, impact of altering braid design and coating formation is investigated. Several combinations braiding parameters manufactured evaluated Beige mouse model infrarenal...
Treadmill running and tibial loading are two common modalities used to assess the role of mechanical stimulation on skeleton preclinically. The primary advantage treadmill is its physiological relevance. However, applied load complex multiaxial, with observed results influenced by cardiovascular musculoskeletal effects. In contrast, loading, a direct uniaxial single bone, providing greater control but less Despite importance wide-spread use both modalities, comparisons lacking. this study,...
An abdominal aortic aneurysm (AAA), defined as a pathological expansion of the largest artery in abdomen, is common vascular disease that frequently leads to death if rupture occurs. Once diagnosed, clinicians typically evaluate risk based on maximum diameter aneurysm, limited metric not accurate for all patients. In this study, we worked additional distinguishing factors between growing and stable murine aneurysms toward aim eventually improving clinical assessment. With use relatively new...
Purpose: Raloxifene (RAL) is a selective estrogen receptor modulator (SERM) that has previously been shown to cause acellular benefits bone tissue. Due these improvements, RAL was combined with targeted tibial loading assess if treatment during periods of active formation would allow for further mechanical enhancements.Methods: Structural, mechanical, and microstructural effects were assessed in from C57BL/6 mice treated (0.5 mg/kg), loading, or both 6 weeks, beginning at 10 weeks...
Raloxifene (RAL) is an FDA-approved drug used to treat osteoporosis in postmenopausal women. RAL suppresses bone loss primarily through its role as a selective estrogen receptor modulator (SERM). This hormonal therapy promotes unintended side effects, such hot flashes and increased thrombosis risk, prevents the from being some patient populations at-risk for fracture, including children with disorders. It has recently been demonstrated that can have significant positive effects on overall...
The specifics of how the nanoscale properties collagen (e.g., crosslinking profile) affect mechanical integrity bone at larger length scales is poorly understood despite growing evidence that collagen's are altered with disease. Additionally, mass independent increases in postyield displacement due to exercise suggest loading-induced improvements quality associated collagen. To test whether disease-induced reductions driven by alterations can be rescued or prevented via exercise-mediated...
Reduced lower-limb blood flow has been shown to lead asymmetrical abdominal aortic aneurysms (AAAs) but the mechanism of action is not fully understood. Therefore, small animal ultrasound (Vevo2100, FUJIFILM VisualSonics) was used longitudinally study mice that underwent standard porcine pancreatic elastase (PPE) infusion (<i>n</i> = 5), and PPE with modified 20% iliac artery stenosis in left 4) right 5) arteries. Human AAA computed tomography images were obtained from patients...
Estrogen agonist raloxifene is an FDA-approved treatment of osteoporosis in postmenopausal women, which may also be a promising prophylactic for painful intervertebral disc (IVD) degeneration. Here, we hypothesized that 1) aging and biological sex contribute to IVD degeneration by reducing estrogen signaling 2) stimulates protect against age- sex-related mice. 2.5-month-old (male female) 22.5-month-old (female) C57Bl/6J mice were subcutaneously injected with hydrochloride 5x/week 6 weeks (n...
ABSTRACT Environmental mechanical cues are critical to guide cell fate. Forces transmit the nucleus through Linker of Nucleo- and Cytoskeleton (LINC) complex thought influence organization chromatin that is related differentiation; however, underlying mechanisms unclear. Here, we investigated reorganization during murine cardiac development found cardiomyocytes establish a distinct architecture characterized by relocation H3K9me3-modified from nuclear interior periphery co-localization...
Abstract Hemorrhage is the second leading cause of death in patients under 46 years age United States. Cessation hemorrhage prevents hemorrhagic shock and tissue hypoxia. Controlling bleed via direct pressure or tourniquet often first line defense, but long‐term care requires staples, hemostatic agents, sealants that seal vessel restore blood flow. Here, we compare a new photocurable extracellular matrix sealant (pcECM) with low, medium, high crosslink density formulations to commercially...