A5074793736- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Psychosomatic Disorders and Their Treatments
- Eating Disorders and Behaviors
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Advanced Neuroimaging Techniques and Applications
- Extracellular vesicles in disease
- Animal Vocal Communication and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural and Behavioral Psychology Studies
- Biochemical Analysis and Sensing Techniques
- Inflammasome and immune disorders
- Mental Health and Psychiatry
- Hearing, Cochlea, Tinnitus, Genetics
- Marine animal studies overview
- Neurotransmitter Receptor Influence on Behavior
- Cardiac Health and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Neuroendocrine regulation and behavior
- Animal Behavior and Reproduction
- Olfactory and Sensory Function Studies
- Myofascial pain diagnosis and treatment
Laureate Institute for Brain Research
2016-2025
University of Oklahoma
2012-2025
University of Tulsa
2016-2025
Oklahoma State University Center for Health Sciences
2025
Mercy Research
2025
Oklahoma State University
2024
KU Leuven
2017
Johnson & Johnson (United States)
2016
University of Oklahoma Health Sciences Center
2011
University of Colorado Boulder
1992
Appetite and weight changes are common but variable diagnostic markers in major depressive disorder: some depressed individuals manifest increased appetite, while others lose their appetite. Many of the brain regions implicated appetitive responses to food have also been depression. It is thus remarkable that there exists no published research comparing neural stimuli patients with versus decreased appetites.Using functional MRI, activity was compared unmedicated or appetite healthy control...
The insula serves as the primary gustatory and viscerosensory region in mammalian cortex. It receives visceral afferent projections through dedicated brainstem thalamic nuclei, which suggests a potential role site for homeostatic integration. For example, while human neuroimaging studies of gustation have implicated dorsal mid-insular cortex one regions insula, other recent this same interoception. This apparent convergence interoceptive information could reflect common neural representation...
Abstract Major depressive disorder (MDD) is associated with interoceptive processing dysfunctions, but the molecular mechanisms underlying this dysfunction are poorly understood. This study combined brain neuronal-enriched extracellular vesicle (NEEV) technology and serum markers of inflammation metabolism Functional Magnetic Resonance Imaging (fMRI) to identify contribution gene regulatory pathways, in particular micro-RNA (miR) 93, MDD. Individuals MDD ( n = 41) healthy comparisons (HC;...
Abstract The homeostatic regulation of feeding behavior requires an organism to be able integrate information from its internal environment, including peripheral visceral signals about the body's current energy needs, with external such as palatability energy‐rich food stimuli. insula, which serves brain's primary sensory cortex for representing both body and taste mouth tongue, is a likely candidate region in this integration might occur. However, date it has been unclear whether these two...
Unmedicated individuals with major depressive disorder (MDD) show abnormal interoception, but it is unclear whether antidepressant treatment via serotonergic medication alters this relationship. The current cross-sectional study examined associations between neural and behavioral indices of interoceptive processing chronic administration in MDD. 47 selective serotonin reuptake inhibitor (SSRI)-medicated MDD (MDD-SSRI) were propensity-matched 48 unmedicated (MDD-UnMed) 41 healthy comparison...
ABSTRACT Extracellular vesicles (EV) which play critical roles in intercellular communication, have garnered interest as biomarkers with researchers studying brain‐related disease processes due to their ability be isolated from various biofluids. Astrocytes, a type of glial cell, role neuronal regulation and function. As such, EV enriched astrocytes can used interrogate cargo identify mechanisms by communicate other cells the central nervous system or shed light on pathophysiological...
The authors sought to determine whether an inflammatory challenge with lipopolysaccharide (LPS) differentially impacts symptoms of anhedonia in participants major depressive disorder high (≥3 mg/L) and low (≤1.5 serum C-reactive protein (CRP) concentrations. Sixty-eight were randomly assigned, a 1:1 ratio, receive LPS (0.8 ng/kg body weight) or placebo (saline) parallel-group double-blind design. Participants stratified according baseline CRP concentrations, yielding four groups: high-CRP...
Abstract Major depressive disorder (MDD) is associated with reductions in white matter microstructural integrity as measured by fractional anisotropy (FA), an index derived from diffusion tensor imaging (DTI). The neurotropic herpesvirus, human cytomegalovirus (HCMV), a major cause of pathology immunosuppressed populations but its relationship FA has never been tested MDD despite the presence inflammation and weakened antiviral immunity subset depressed patients. We between HCMV infection...
A subset of major depressive disorder (MDD) is characterized by immune system dysfunction, but the intracellular origin these changes remains unclear. Here we tested hypothesis that abnormalities in endoplasmic reticulum (ER) stress, inflammasome activity and mitochondrial biogenesis contribute to development systemic inflammation MDD. RT-qPCR was used measure mRNA expression key organellar genes from peripheral blood mononuclear cells (PBMCs) isolated 186 MDD 67 healthy control (HC)...
Background: Dysregulated ventral striatum function has been proposed as one important process occurring in individuals with substance use disorder. This study investigates the role of altered reward and loss anticipation, which is an component impaired decision-making, impulsivity, vulnerability to relapse amphetamine disorder (AMP). Aims: To determine whether AMP associated blunted striatum, prefrontal cortex, insula signals during win anticipation. Methods: Participants without (AMP+ n =...
The classic steroid hormone estradiol is rapidly produced by central auditory neurons in the songbird brain and instantaneously modulates coding to enhance neural behavioral discrimination of acoustic signals. Although recent advances highlight novel roles for regulation processing, current knowledge on functional neurochemical organization estrogen-associated circuits, as well impact sensory experience these forebrain networks, remains very limited. Here we show that both estrogen-producing...
Human cytomegalovirus (HCMV) is a neurotropic herpes virus known to cause neuropathology in patients with impaired immunity. Previously, we reported reduction the gray matter volume (GMV) of several brain regions two independent samples participants who were seropositive for HCMV (HCMV+) compared matched seronegative (HCMV-). In addition an replication GMV findings, this study aimed examine whether HCMV+ was associated differences resting-state functional connectivity (rsfMRI-FC). After...
Abstract Elevated serum concentrations (>3 mg/L) of the acute-phase protein, C-reactive protein (CRP), is used as a clinical marker inflammation and reported to be strong risk factor for cardiovascular disease. In psychiatric populations, CRP concentration higher in depressed versus healthy individuals. Positive associations between depression have been established both community samples, but effect sizes are attenuated after controlling confounding variables. Similarly, emerging research...
The classic female estrogen, 17β-estradiol (E2), has been repeatedly shown to affect the perceptual processing of visual cues. Although gonadal E2 often thought influence these processes, possibility that central may be modulated by brain-generated hormone not explored. Here we show estrogen-associated circuits are highly prevalent in mouse primary cortex (V1). Specifically, cloned aromatase, a marker for estrogen-producing neurons, and estrogen receptors (ERs) ERα ERβ, as markers...