A5051341850- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Advanced biosensing and bioanalysis techniques
- Histone Deacetylase Inhibitors Research
- Metal complexes synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Suicide and Self-Harm Studies
- Hydrogels: synthesis, properties, applications
- T-cell and B-cell Immunology
- Advanced X-ray and CT Imaging
- Immune cells in cancer
- Hematopoietic Stem Cell Transplantation
- Poisoning and overdose treatments
- Kidney Stones and Urolithiasis Treatments
- Nanoplatforms for cancer theranostics
- Cancer, Stress, Anesthesia, and Immune Response
- Renal and Vascular Pathologies
- Catalytic C–H Functionalization Methods
- RNA Interference and Gene Delivery
- Polymer composites and self-healing
- Nanocluster Synthesis and Applications
- Advanced Sensor and Energy Harvesting Materials
- Synthetic Organic Chemistry Methods
- Forensic Entomology and Diptera Studies
Università della Svizzera italiana
2024
Ente Ospedaliero Cantonale
2024
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2017-2021
Ente Ospedaliero Ospedali Galliera
2021
Fondazione IRCCS Istituto Nazionale dei Tumori
2020
Torino e-district
2020
Polytechnic University of Turin
2020
Azienda Sanitaria Locale Alessandria
2017-2018
University of Genoa
2010-2011
The design, synthesis, characterization and biological properties of a Pt(iv) complex containing the very active inhibitor histone deacetylase (2-propynyl)octanoic acid, POA, as an axial ligand are reported here. title complex, namely (OC-6-44)-acetatodiamminedichlorido(2-(2-propynyl)octanoato)platinum(iv), 1, POA in racemic or enantiomeric forms, was one/two orders magnitude more than cisplatin, depending on chemo-sensitivity cancer cell lines. Moreover, 1 exhibited similar even better...
Multi-action cisplatin-based mono- (1) and di-clofibric acid (2) Pt(iv) "combo" derivatives were synthesized via both traditional microwave assisted procedures. The two complexes offered very good performances (IC50 values in a nanomolar range) on panel of human tumor cell lines, including the highly chemoresistant malignant pleural mesothelioma ones. Moreover, 1 2 bypass cisplatin resistance. Indeed, clofibric acid, metabolites → Pt(ii) intracellular reduction, proved to act...
Comparison between the antiproliferative properties of a Pt(<sc>iv</sc>)-valproato complex and its metabolites indicates that former is more active because it unremoved from cells.
Oxidation of [Pt(II)Cl(terpy)]+ (terpy = 2,2':6',2''-terpyridine) has been attempted with several oxidizing agents and under different experimental conditions in order to obtain a Pt(iv) complex suitable for the conjugation nanovectors be used drug delivery targeting anticancer therapy. The best compromise terms yield purity final was obtained by microwave-assisted reaction at 70 °C 50% aqueous H2O2 2 h. Under these quantitative formation [Pt(IV)Cl(OH)2(terpy)]+ observed. subsequent...
A library of poly(ether urethane)-based supramolecular hydrogels was designed, showing quick gelation, no phase separation, remarkable mechanical and self-healing properties.
Abstract Piezoelectric ceramic nanomaterials have recently attracted attention in the biomedical field thanks to their interesting electrical properties response mechanical stimulation (and vice versa) combined with a good biocompatibility and ability promote regeneration of electrically sensitive tissues. In tissue engineering approaches, order obtain smart scaffolds these materials must be other biomaterials for processing through conventional as well non-conventional technologies. this...
In Italy, an HLA-matched unrelated donor is currently the primary when a HLA matched sibling not found for allogeneic haematopoietic stem cell transplantation (HSCT). Better outcomes require optimal matching between and recipient at least HLA-A, -B, -C, -DRB1 loci; therefore, availability of donors important. The enormous polymorphism has always necessitated registries with large number individuals in order to be able provide well-matched substantial percentage patients. increase efficiency...
Introduction Every year between 100’000 and 200’000 young people die by suicide possibly 40 times as many attempt it [1]. Several studies analyze the seasonality of in general population, but few them investigate among adults. Objectives We look for a seasonal pattern suicidal behaviors performed adults evaluate lethality their behaviors. Aims test hypothesis that (a) follow (b) acts males have different those carried out females. Methods Analyses are based on data 3614 cases behaviours...
Objectives Suicide is a complex phenomenon accounting for 1 million deaths per year. This study aims to assess the profiles of those individuals at higher risk suicide, which may be help clinicians while evaluating patients. Methods A sample 30.000 suicides belonging two age-bands, i.e. 18 24 and over-45s, was analysed compared with respect gender, fatality act, season, reason it, time methods employed. Data were provided by ISTAT records concern completed attempted in Italy from 2001-2008....