A5102852688- Click Chemistry and Applications
- Biotin and Related Studies
- Primary Care and Health Outcomes
- Protein Degradation and Inhibitors
- S100 Proteins and Annexins
- Neurological disorders and treatments
- Computational Drug Discovery Methods
- RNA regulation and disease
- Health Services Management and Policy
- Healthcare Policy and Management
- RNA Interference and Gene Delivery
- World Wars: History, Literature, and Impact
- European Political History Analysis
- Historical and Contemporary Political Dynamics
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
Scripps (United States)
2023-2025
Scripps Research Institute
2024-2025
Massachusetts General Hospital
2025
University of Montana
2023
Huntington's disease, one of more than 50 inherited repeat expansion disorders1, is a dominantly neurodegenerative disease caused by CAG in HTT2. Inherited length the primary determinant age onset, with human genetic studies underscoring that driven length-dependent propensity to further expand brain3–9. Routes slowing somatic expansion, therefore, hold promise for disease-modifying therapies. Several DNA repair genes, notably mismatch pathway, modify mouse models10. To identify novel...
mRNA lipid nanoparticles (LNPs) have emerged as powerful modalities for gene therapies to control cancer and infectious immune diseases. Despite the escalating interest in mRNA-LNPs over past few decades, endosomal entrapment of delivered mRNAs vastly impedes therapeutic developments. In addition, molecular mechanism LNP-mediated delivery is poorly understood guide further improvement through rational design. To tackle these challenges, we characterized using a library small molecules...
Abstract Proximity labeling traditionally identifies interactomes of a single protein or RNA, though this approach limits mechanistic understanding biomolecules functioning within complex systems. Here, we demonstrate strategy for deciphering ligand-induced changes to global biomolecular interactions by enabling proximity labelling at the mesoscale, across an entire cellular system. By inserting nanoscale catalysts throughout chromatin, system, MesoMap, provided new insights into how HDAC...
If you have three quarters of an hour to spare and happen be in the right place at time, there are few gatherings match a decent medical funeral. In teaching centre like ours they provide unpredictable but nonetheless welcom reunions that allow sentiment, certain amount communal pride, - not incidentally chance agree old Joe had his rough side/cross bear/undoubted shortcomings, nevertheless did great deal/a fair bit/as much as could been expected, for Edinburgh medicine general own specialty...
Here in Auchendreich, far removed from the frenetic pace of events common great teaching centres, we pride ourselves on taking longer view. This is part a feature innate stolidity semi-rural Scot, and matter evidence based realism: our flagship new hospital, opened only last May, was, after all, its planning stages for more than 30 years. So at all levels there recognition that …