A5008312473- Fluorine in Organic Chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Enzyme Catalysis and Immobilization
- Biosensors and Analytical Detection
- Cyclopropane Reaction Mechanisms
- Inorganic Fluorides and Related Compounds
- Advanced biosensing and bioanalysis techniques
- Catalytic C–H Functionalization Methods
- Analytical Chemistry and Sensors
- Acoustic Wave Resonator Technologies
- Chemical Synthesis and Analysis
- Microbial Metabolic Engineering and Bioproduction
- Catalytic Cross-Coupling Reactions
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Asymmetric Synthesis and Catalysis
- Advanced Biosensing Techniques and Applications
- Synthesis and Catalytic Reactions
- Lipid Membrane Structure and Behavior
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Biochemical and Molecular Research
- Click Chemistry and Applications
- Biotin and Related Studies
Shanghai Institute of Organic Chemistry
2020-2025
Chinese Academy of Sciences
2022-2025
The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
2025
Scripps (United States)
2025
Taizhou University
2023-2024
Tianjin Institute of Industrial Biotechnology
2022-2023
Anhui University
2022
University of Chinese Academy of Sciences
2020-2021
Nanyang Institute of Technology
2016-2018
Soochow University
2018
Selective functionalization of inactive C(sp3)-F bonds to prepare medicinally interesting aryldifluoromethylated compounds remains challenging. One promising route is the transition-metal-catalyzed cross-coupling through oxidative addition bond in trifluoromethylarenes (ArCF3), which are ideal precursors for this process due their ready availability and low cost. Here, we report an unprecedented excited-state palladium catalysis strategy selective defluoroarylation with arylboronic acids....
Asymmetric dearomative [3 + 2] cycloaddition reactions of 3-nitroindoles with vinyl aziridine and cyclopropanes have been respectively successfully developed in the presence a chiral box/Pd(0) complex. A series enantiomerically enriched 3a-nitro-hexahydropyrrolo[2,3-b]indole 8b-nitrohexahydrocyclopenta[b]indole derivatives containing three contiguous centers are smoothly obtained high yields satisfactory regio-, chemo-, enantioselectivity. Remarkably, synthetic utility this process was...
This work summarizes recent progress in nickel-catalyzed propargylic substitution reactions, categorizing them based on the diverse types of nucleophiles involved, with a specific focus exploring asymmetric transformations.
Photocatalytic proximity labeling has emerged as a valuable technique for studying interactions between biomolecules in cellular context, providing precise spatiotemporal control over protein labeling. One significant advantage of these methods is their modularity, allowing the use single photocatalyst with different reactive probes to expand interactome coverage and capture diverse interactions. Despite advances, fewer have been developed using red-light excitation, limiting photoproximity...
Abstract Biocatalysis is increasingly replacing traditional methods of manufacturing fine chemicals due to its green, mild, and highly selective nature, but biocatalysts, such as enzymes, are generally costly, fragile, difficult recycle. Immobilization provides protection for the enzyme enables convenient reuse, which makes immobilized enzymes promising heterogeneous biocatalysts; however, their industrial applications limited by low specific activity poor stability. Herein, we report a...
Efficient construction of optically pure molecules from readily available starting materials in a simple manner is an ongoing goal asymmetric synthesis. As straightforward route, transition-metal-catalyzed enantioconvergent coupling between widely secondary alkyl electrophiles and organometallic nucleophiles has emerged as powerful strategy to construct chiral center(s). However, the scope racemic alkylmetallic for this remains limited specific substrates because difficulties stereoselective...
Photoinduced decarbonylative C-C bond formation with readily accessible aldehydes as alkyl sources is described. This protocol provides a sustainable alternative for the effective construction of diverse valuable 4-alkylated sulfonyl ketimines under metal- and photosensitizer-free conditions. Significantly, in this reaction, air serves green oxidant, cyclic sulfamidate imines play dual role substrate photocatalyst, thus affording concise reaction system C-H alkylation imines.
Abstract The enantioselective construction of C–CF 2 R (R: alkyl or fluoroalkyl) bonds has attracted the attention synthetic chemists because importance chiral fluorinated compounds in life and materials sciences. Catalytic asymmetric fluoroalkylation mainly been realized under organocatalysis Lewis acid catalysis, with substrates limited to carbonyl compounds. Few examples using transition-metal catalysis exist, owing side reactions including decomposition isomerization fluoroalkylating...
Propargylic alcohols and amines are versatile building blocks in organic synthesis. We demonstrate a straightforward enzymatic cascade to synthesize enantiomerically pure propargylic from readily available racemic starting materials. In the first step, peroxygenase Agrocybe aegerita converted into corresponding ketones, which then were using (R)-selective alcohol dehydrogenase Lactobacillus kefir or (S)-selective Thermoanaerobacter brokii. Moreover, an Mitsunobu-type conversion of enriched...
Abstract Proximity labeling traditionally identifies interactomes of a single protein or RNA, though this approach limits mechanistic understanding biomolecules functioning within complex systems. Here, we demonstrate strategy for deciphering ligand-induced changes to global biomolecular interactions by enabling proximity labelling at the mesoscale, across an entire cellular system. By inserting nanoscale catalysts throughout chromatin, system, MesoMap, provided new insights into how HDAC...
Fluoroalkylated amines play a pivotal role in medicinal chemistry, yet the general and efficient synthesis of β‐difluoroalkylated remains elusive. Here, we developed nickel‐catalyzed umpolung strategy that enables difluoroalkylation 2‐azaallyl anions generated from aliphatic aromatic imines, effectively overcoming previous limitations. By inverting polarity this allows for coupling variety readily accessible difluoroalkyl bromides iodides. This approach is characterized by its high...
Fluoroalkylated amines play a pivotal role in medicinal chemistry, yet the general and efficient synthesis of β‐difluoroalkylated remains elusive. Here, we developed nickel‐catalyzed umpolung strategy that enables difluoroalkylation 2‐azaallyl anions generated from aliphatic aromatic imines, effectively overcoming previous limitations. By inverting polarity this allows for coupling variety readily accessible difluoroalkyl bromides iodides. This approach is characterized by its high...
Unraveling the mechanism of “Switches” (positions 294 and 295) that specifically control inversion product chirality by dry wet experimental analysis.
A new multichannel series piezoelectric quartz crystal (MSPQC) cell sensor for real time monitoring of living cells in vitro was reported this paper. The constructed used successfully to monitor adhesion, spreading, proliferation, and apoptosis MG63 osteosarcoma investigate the effects different concentrations cobalt chloride on cells. Quantitative dynamic analyses data were conducted using MSPQC sensor. Compared with methods such as fluorescence staining morphology observation by...
Chiral amino alcohols are prevalent synthons in pharmaceuticals and synthetic bioactive compounds. The efficient synthesis of chiral using ammonia as the sole donor under mild conditions is highly desired challenging organic chemistry biotechnology. Our previous work explored a panel engineered amine dehydrogenases (AmDHs) derived from acid dehydrogenase (AADH), enabling one-step via asymmetric reductive amination α-hydroxy ketones. Although AmDH-directed reduction high stereoselective...
For the first time, a porous gel-monolithic microreactor with high catalytic-activity and stability was developed via in situ assembling of alcohol-dehydrogenase.
Biological information is obtained from the interaction between series detection electrode and organism or physical field of biological cultures in non-mass responsive piezoelectric biosensor. Therefore, electric parameter will affect biosensor signal. The distribution microelectrode used this study was simulated using COMSOL Multiphysics analytical tool. This process showed that spatial affected by width finger space electrodes. In addition, characteristic response sensor constructed...