A5103228987- Radiomics and Machine Learning in Medical Imaging
- Long-Term Effects of COVID-19
- MRI in cancer diagnosis
- Colorectal Cancer Screening and Detection
- COVID-19 and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Intensive Care Unit Cognitive Disorders
- Bioinformatics and Genomic Networks
- COVID-19 Clinical Research Studies
- Pancreatic and Hepatic Oncology Research
- Gene expression and cancer classification
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Microtubule and mitosis dynamics
- Ovarian cancer diagnosis and treatment
- Pharmaceutical Practices and Patient Outcomes
- Colorectal Cancer Treatments and Studies
- Pituitary Gland Disorders and Treatments
- Pharmacogenetics and Drug Metabolism
- Statistical Methods in Clinical Trials
- Medical Imaging and Analysis
- Mosquito-borne diseases and control
Fudan University
2018-2025
Zhongshan Hospital
2018-2024
The First Affiliated Hospital, Sun Yat-sen University
2018-2024
Sun Yat-sen University
2018-2024
Optum (United States)
2021-2023
UnitedHealth Group (United States)
2020-2023
Okinawa Prefectural Chubu Hospital
2023
United Imaging Healthcare (China)
2021
Shanghai Institute of Organic Chemistry
2021
Chinese Academy of Sciences
2021
To evaluate the excess risk and relative hazards for developing incident clinical sequelae after acute phase of SARS-CoV-2 infection in adults aged 18-65.Retrospective cohort study.Three merged data sources from a large United States health plan: national administrative claims database, an outpatient laboratory testing inpatient hospital admissions database.Individuals 18-65 with continuous enrollment plan January 2019 to date diagnosis infection. Three comparator groups, matched by...
Abstract Objective To characterize the risk of persistent and new clinical sequelae in adults aged ≥65 years after acute phase SARS-CoV-2 infection. Design Retrospective cohort study. Setting UnitedHealth Group Clinical Research Database: deidentified administrative claims outpatient laboratory test results. Participants Individuals who were continuously enrolled a Medicare Advantage plan with coverage prescription drugs from January 2019 to date diagnosis infection, matched by propensity...
Background: Whether angiotensin-converting enzyme (ACE) Inhibitors and angiotensin receptor blockers (ARBs) mitigate or exacerbate SARS-CoV-2 infection remains uncertain. In a national study, we evaluated the association of ACE inhibitors ARB with coronavirus disease-19 (COVID-19) hospitalization mortality among individuals hypertension. Methods: Among Medicare Advantage commercially insured individuals, identified 2,263 people hypertension, receiving ≥1 antihypertensive agents, who had...
Background Despite its clinical significance, the risk of severe infection requiring hospitalization among outpatients with acute respiratory syndrome coronavirus 2 who receive angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) remains uncertain. Methods Results In a propensity score-matched outpatient cohort (January-May 2020) 2263 Medicare Advantage commercially insured individuals hypertension positive SARS-CoV-2, we determined association ACE ARBs...
The aim of this study was to investigate whether quantitative and qualitative features extracted from PET/computed tomography (CT) can be used as imaging biomarkers for evaluating epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer patients.Eighty patients with stage II III January 2017 December were included study. All underwent PET/CT examination before operation. Patients 30 EGFR positive 50 negative confirmed by pathological verification gene detection....
Abstract The enantioselective construction of C–CF 2 R (R: alkyl or fluoroalkyl) bonds has attracted the attention synthetic chemists because importance chiral fluorinated compounds in life and materials sciences. Catalytic asymmetric fluoroalkylation mainly been realized under organocatalysis Lewis acid catalysis, with substrates limited to carbonyl compounds. Few examples using transition-metal catalysis exist, owing side reactions including decomposition isomerization fluoroalkylating...
Abstract Background Low back pain (LBP) is prevalent, management benefits from high-quality clinical practice guidelines, and yet LBP a common source of low value care. The purpose this retrospective cohort study was to examine the association between type initial contact health care provider (HCP), service utilization, total episode cost for LBP. Methods Episode used analyze US national sample episodes completed in 2017-2019. A combined surgical non-surgical (pooled) were separately...
Abstract Objective Clinical sequelae have not been well characterized during the post-acute phase of SARS-CoV-2 among adults 18 to 65 years old, and this study sought fill that gap by evaluating excess risk relative hazards for developing incident clinical phase. Design Retrospective cohort including three propensity-matched groups. Setting This merged data sources from a large United States health plan: national administrative claims database, an outpatient lab testing inpatient hospital...
We investigate the training and generalization errors of overparameterized neural networks (NNs) with a wide class leaky rectified linear unit (ReLU) functions. More specifically, we carefully upper bound both convergence rate error such NNs dependence these bounds on Leaky ReLU parameter, $\alpha$. show that $\alpha =-1$, which corresponds to absolute value activation function, is optimal for bound. Furthermore, in special settings, it also Numerical experiments empirically support...
Accurate estimation of the recurrence pancreatic neuroendocrine tumors help with prognosis, guide follow-up, and avoid futile treatments.To investigate whether MRI features could preoperatively estimate (PNETs) to refine a novel prognostic model through developing nomogram incorporating various features.Retrospective.In all, 81 patients clinicopathologically confirmed nonmetastatic PNETs.1.5 T MR, including T1 -weighted, T2 diffusion-weighted imaging sequences.Qualitative quantitative PNET...
To explore whether monoclonal antibodies (MAb) administered to high-risk patients with COVID-19 during the first week of illness prevent postacute sequelae SARS-CoV-2 infection.Retrospective cohort study.USA.A sample 3809 individuals who received MAbs and a matched one-to-one comparison group from set 327 079 eligible did not receive MAb treatment were selected deidentified administrative data commercial Medicare Advantage health plan enrollees in USA, including claims outpatient laboratory...
Gene set analysis methods rely on knowledge-based representations of genetic interactions in the form both gene collections and protein-protein interaction (PPI) networks. However, explicit often fail to capture complex interdependencies among genes, limiting analytic power such methods.
While colorectal cancer (CRC) is the second leading cause of cancer-related mortality in United States (US), outcomes can be improved through timely screening. Despite benefits and widespread availability screening tests, adherence to recommended strategies low. The study aimed provide recent evidence regarding rates recommendations among adults at average risk for CRC a commercially insured Medicare Advantage population. De-identified administrative data from large US research database were...
Abstract Although vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been successful, there are no good treatments those who actively infected. While SARS-CoV-2 primarily infects the tract, clinical evidence indicates that cells from sensory organs and brain also susceptible to infection. many patients suffer diverse neurological symptoms, virus’s neuronal entry remains mysterious. To discover host factors involved in viral entry, we performed CRISPR activation...
Effective colorectal cancer (CRC) screening requires proper adherence beginning at the recommended age. For those with positive results on stool-based tests (SBTs), a follow-up colonoscopy is warranted. The objectives of this study were to 1) examine initial rates after turning 50 years old; and 2) assess SBT.This retrospective used de-identified administrative claims data from 01/01/2006 06/30/2020 for commercially insured Medicare Advantage enrollees. objective 1, index year was enrollees...
Unmanaged pharmacogenomic and drug interaction risk can lengthen hospitalization may have influenced the severe health outcomes seen in some COVID-19 patients. To determine if unmanaged risks were associated with longer lengths of stay (LOS) among patients hospitalized COVID-19, we retrospectively reviewed medical pharmacy claims from 6025 Medicare Advantage members COVID-19. Patients a moderate or high pharmacogenetic probability (PIP), which indicates likelihood that testing would identify...
<title>Abstract</title> Purpose Pituitary neuroendocrine tumors (PitNETs) with invasion of the cavernous sinus (CS) are particularly challenging to treat. Cancer associated fibroblasts (CAFs) recognized for their pivotal role in reprogramming extracellular matrix (ECM). Herein, we aimed explore potential involvement CAFs ECM and elucidate underlying mechanism involved. Methods We applied dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measure tumor vessel permeability atomic...