A5045328411- Bacterial biofilms and quorum sensing
- Plant-Microbe Interactions and Immunity
- Fungal and yeast genetics research
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Plant and Fungal Interactions Research
- RNA and protein synthesis mechanisms
- Cellular Mechanics and Interactions
- Glycosylation and Glycoproteins Research
- Plant Disease Resistance and Genetics
- Microtubule and mitosis dynamics
- Studies on Chitinases and Chitosanases
- Protein Structure and Dynamics
Inserm
2022-2025
Université de Montpellier
2022-2025
Centre National de la Recherche Scientifique
2022-2025
Centre de Biologie Structurale
2022-2025
Magnaporthe AVRs and ToxB-like (MAX) effectors constitute a family of secreted virulence proteins in the fungus Pyricularia oryzae (syn . oryzae) , which causes blast disease on numerous cereals grasses. In spite high sequence divergence, MAX share common fold characterized by ß-sandwich core stabilized conserved disulfide bond. this study, we investigated structural landscape diversity within effector repertoire P Combining experimental protein structure determination silico modeling...
Does a similar 3D structure mean folding pathway? This question is particularly meaningful when it concerns proteins sharing structure, but low sequence identity or homology. MAX effectors secreted by the phytopathogenic fungus
Abstract Fungal effectors play crucial roles in plant infection. Despite low sequence identity, were recently classified into structural families. In this study, we have elucidated the structures of Zt-NIP1 and Mycgr3-91409 wheat fungal pathogen Zymoseptoria tritici, using X-ray crystallography NMR. These displayed a homology with, respectively, KP4 KP6α killer toxins, from UmV dsRNA viruses infecting corn Ustilago maydis . Consequently, renamed Zt-KP4-1 Zt-KP6-1. Orthologs paralogs Zt-KP6-1...
Despite advances in experimental and computational methods, the mechanisms by which an unstructured polypeptide chain regains its unique three-dimensional structure remains one of main puzzling questions biology. Single-molecule techniques, ultra-fast perturbation detection approaches improvement all-atom coarse-grained simulation methods have greatly deepened our understanding protein folding effects environmental factors on landscape. However, a major challenge detailed characterization...
ABSTRACT Magnaporthe AVRs and ToxB-like (MAX) effectors constitute a family of secreted virulence proteins in the fungus Pyricularia oryzae (syn. oryzae) , which causes blast disease on numerous cereals grasses. In spite high sequence divergence, MAX share common fold characterized by ß-sandwich core stabilized conserved disulfide bond. this study, we investigated structural landscape diversity within effector repertoire P. oryzae. Combining experimental protein structure determination...