A5042979357- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- RNA modifications and cancer
- Bone health and osteoporosis research
- Osteoarthritis Treatment and Mechanisms
- Angiogenesis and VEGF in Cancer
- Rheumatoid Arthritis Research and Therapies
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- Apelin-related biomedical research
- Vitamin D Research Studies
- Signaling Pathways in Disease
- Inflammatory mediators and NSAID effects
- Capital Investment and Risk Analysis
- Immune Cell Function and Interaction
- Silk-based biomaterials and applications
- Bone fractures and treatments
- Bone and Joint Diseases
- Tryptophan and brain disorders
- Cardiac and Coronary Surgery Techniques
- Bone and Dental Protein Studies
China Medical University
2016-2023
Sheng Jing Hospital
2018-2023
University College London
2022
First Hospital of Lanzhou University
2018-2021
Lanzhou University
2018-2021
TRIM29 overexpression has been reported in several human malignancies and showed correlation with cancer cell malignancy. The aim of the current study is to examine its clinical significance biological roles bladder tissues lines.A total 102 cases were examined for expression by immunohistochemistry. siRNA plasmid transfection performed 5637 BIU-87 lines. Cell Counting Kit-8, flow cytometry, western blot, real-time polymerase chain reaction mechanism cells.We found that invading depth...
Glucocorticoid (GC)-induced osteoporosis (GIO) is one of the most common secondary and iatrogenic forms osteoporosis. GCs are widely used in clinical therapy play a key role normal regulation bone remodeling. However, prolonged high-dose administration results occurrence osteoporosis, which partially due to dysfunction apoptosis osteoblasts osteocytes. The aim present study was investigate effects gastrodin, natural bioactive compound isolated from traditional Chinese herbal agent Gastrodia...
Background: Prolonged administration of overdoses glucocorticoids results in increased bone remodeling, leading to glucocorticoid-induced osteoporosis (GIO), which is primarily due the dysfunction and apoptosis osteoblasts. The present study investigated therapeutic effect molecular mechanism action epigallocatechin-3-gallate (EGCG), a bioactive catechin green tea, high-dose dexamethasone-induced osteoblast differentiation vivo vitro. Methods: anti-dexamethasone (DEX) effects EGCG on primary...
Paeoniflorin, a natural product derived from Paeonia lactiflora, possesses diverse pharmacological activities such as anti-inflammatory, antitumor, and antidiabetic effects. It has been reported for promoting osteoblastogenesis inhibiting osteoclastogenesis. This study investigates the therapeutic effects of paeoniflorin in glucocorticoid-induced osteoporosis (GIOP) vitro vivo. MC3T3-E1 cells were incubated with dexamethasone (DEX; 200 μM) and/or (10 μM), followed by investigation cell...
Despite advances in the understanding of neoplasm, patients with cervical cancer still have a poor prognosis. Identifying prognostic markers may enable early detection recurrence and more effective treatment.Gene expression profiling data were acquired from Gene Expression Omnibus database. After normalization, genes large variation screened out. Next, we built co-expression modules by using weighted gene network analysis to investigate relationship between clinical traits related...
Prolonged and over-dosed administration of glucocorticoids results in more bone remodeling, leading to glucocorticoid-induced osteoporosis, which is primarily due dysfunction apoptosis osteoblasts. The present study investigated the therapeutic effect molecular mechanism gastrodin, a natural bioactive compound isolated from traditional Chinese herbal agent Gastrodia elata, on osteoblastic cells vivo vitro.The anti-dexamethasone (DEX) effects gastrodin primary osteoblasts were measured by...
MicroRNAs (miRNAs) are considered to be critical mediators of gene expression with respect tumor progression, although their role in ischemia‑induced angiogenesis is poorly characterized, including peripheral arterial disease (PAD). Furthermore, the underlying mechanism action specific miRNAs PAD remains unknown. Reverse transcription‑quantitative polymerase chain reaction analysis revealed that microRNA‑93 (miR‑93) was significantly upregulated patients and EA.hy926 endothelial cells...
Abstract Background Osteosarcoma is a malignant tumor that usually occurs in adolescents aged 10–20 years and associated with poor prognosis. Ferroptosis an iron-dependent cell death mechanism plays vital role cancer. Methods transcriptome data were downloaded from the public database TARGET previous studies. A prognostic risk score signature was constructed using bioinformatics analysis, its efficacy determined by analyzing typical clinical features. The then validated external data....
Arbutin is a natural compound extracted from various plants, including bearberry leaves, that exerts multiple effects skin whitening, anti‑inflammatory and oxidative stress‑protective properties. However, the of arbutin on osteoblasts remain unknown. The aim present study was to investigate function mechanisms proliferation differentiation MC3T3‑E1 mouse osteoblast precursor cells in vitro. treated with assessed using Cell Counting Kit‑8 assay 5‑ethynyl‑2'‑deoxyuridine labeling assay....
Shikonin, the predominant naphthoquinone pigment isolated from Chinese plant Lithospermum erythrorhizon, is anti‑inflammatory, antiviral and exerts anticancer effects, amongst other biological activities. However, it unknown whether shikonin affects bone formation. In present study, role of on cell proliferation was assessed via MTT assay, identified to markedly promote growth in a time‑ dose‑dependent manner MC3T3‑E1 line. addition, flow cytometric analysis performed evaluate effect cycle,...
Leonurine hydrochloride (LH) is a synthetic chemical compound derived from leonurine that can be extracted Leonurus sibiricus and possesses antioxidant, anti-apoptosis, neuroprotective activities. In previous studies, LH has been demonstrated to attenuate osteoclast activity prevent bone loss. However, it unknown whether accelerates formation promotes osteogenic differentiation. We systematically examined the effects of on ovariectomized-induced osteoporotic mice MC3T3-E1 osteoblastic cell...
Background: Osteosarcoma (OSA) is the most prevalent form of malignant bone cancer and it occurs predominantly in children adolescents. OSA associated with a poor prognosis highest cause cancer-related death. However, there are few biomarkers that can serve as reasonable assessments prognosis. Methods: Gene expression profiling data were downloaded from dataset GSE39058 GSE21257 Expression Omnibus database well TARGET database. Bioinformatic analysis integration was conducted to discover...
Osteoarthritis (OA) is a chronic arthropathy that frequently occurs in the middle-aged and elderly population. The aim of this study was to investigate molecular mechanism OA based on autophagy theory.We downloaded gene expression profile from Gene Expression Omnibus repository. Differentially expressed genes (DEGs) related keyword "autophagy" were identified using scanGEO online analysis tool. DEGs representing same trend screened MATCH function. Clinical synovial specimens collected for...
Effect of revascularization in the treatment thromboangiitis obliterans (TAO) and predictive value serum vascular endothelial growth factor (VEGF), interleukin-1 (IL-1) tumor necrosis factor-α (TNF-α) risk factors amputation were investigated. From April 2012 to August 2015, a total 117 patients with TAO admitted First Hospital Lanzhou University selected. Patients treated combined prostaglandin sodium cilostazol enrolled group A (67 patients), B (50 patients). The clinical efficacy was...
Objective: Both exercise and cold exposure cause physiological stress they often occur in combination. However, the effects of during severe on variation bone metabolism humans have remained elusive. The aim this study was to investigate variations circulating markers after ice swimming (IS). Methods: Eighty-seven women men aged 42-84 years old were recruited perform regular IS activities. Serum parathyroid hormone (PTH), total calcium (Ca2+), phosphorus (Pi), magnesium (Mg2+), N-terminal...
The effects of different doses folic acid and vitamin B12 on rabbits with deep vein thrombosis (DVT) hyperhomocysteinemia were investigated. In total, 60 New Zealand divided into untreated control, low-dose high-dose groups. After inducing DVT, hemorheology coagulation indexes measured 3 10 days later. We found that both treatment groups performed better than the control group, low-dose. Ten after thrombosis, levels Hcy D-dimer lower in group. Moreover, changes extremity venous significantly...