A5032680618- Antifungal resistance and susceptibility
- Ginkgo biloba and Cashew Applications
- Essential Oils and Antimicrobial Activity
- Plant chemical constituents analysis
- Medicinal Plants and Neuroprotection
- Fungal Infections and Studies
- Advanced Drug Delivery Systems
- Synthesis and biological activity
Pontificia Universidad Javeriana
2020-2024
Universidade Federal Fluminense
2022
Invasive fungal disease causes high morbidity and mortality among immunocompromised patients. Resistance to conventional antifungal drugs the toxicity associated with doses highlight need for effective therapies. In this study, potential of ethanolic extract
Amphotericin B (AmB) is a broad spectrum of antifungal drug used to treat diseases. However, due the high toxicity AmB, treated patients may suffer risk side effects, such as renal failure. Nanoencapsulation strategies have been reported elicit low toxicity, albeit most them possess encapsulation efficiency. The aim this research develop micellar delivery systems for AmB with reduced while maintaining its affectivity by employing retinol (RET)-conjugated amphiphilic block copolymers (ABCs)...
Invasive fungal disease causes high morbidity and mortality among immunocompromised patients. Anti-fungal drug resistance cytotoxicity highlight the need for effective antifungal therapeutics. In this study, potential of ethanolic extract Anacardium occidentale (Cashew Leaf) leaves were evaluated against Candida albicans C. auris. The activity was tested by broth microdilution method growth kinetic test. To further explore its action mode, spectrofluorophotometry, confocal microscopy...
Mycoses annually affect about 2 million individuals worldwide, especially in tropical countries. Candida spp., one of the main etiologic agents these mycoses, and particular albicans has been most isolated pathogen patients with severe clinical cases invasive candidiasis candidemia, causing frequent infections or opportunistic chronic systemic forms. However, emergence non-albicans become a public health concern worldwide. In discovering har.mless molecules, pyrazoles have attracted many...