A5082226030- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and gingival health research
- Head and Neck Cancer Studies
- Salivary Gland Disorders and Functions
- Autoimmune Bullous Skin Diseases
- Vascular Malformations and Hemangiomas
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders
- Neurofibromatosis and Schwannoma Cases
- Tryptophan and brain disorders
- Periodontal Regeneration and Treatments
- Neurological Complications and Syndromes
- Dysphagia Assessment and Management
- Pediatric health and respiratory diseases
- Glycogen Storage Diseases and Myoclonus
- Sleep and related disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hedgehog Signaling Pathway Studies
- Cancer and Skin Lesions
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
- Bone Tumor Diagnosis and Treatments
Kuopio University Hospital
2014-2025
University of Eastern Finland
2018-2025
University of Oulu
2008-2023
Finland University
2019-2020
Oulu University Hospital
2007-2018
Objective To carry out a double‐blind randomized controlled trial ( RCT ) to compare the effectiveness of topical tacrolimus TAC ), triamcinolone acetonide TRI and placebo PLA in symptomatic oral lichen planus OLP ). Subjects Methods A clinical score CS , range 0–130) was developed measure signs symptoms . Twenty‐seven patients with ≥20 were randomly allocated receive 0.1% ointment n = 11), paste 7), or Orabase ® as 9) for 3 weeks. If dropped ≥20% (interpreted response), continued same...
ABSTRACT Background Updated and comprehensive epidemiological data on odontogenic tumors are not available for the Nordic countries. The aim of study was to retrospectively examine prevalence clinical radiological characteristics primary over a 10‐year period in Sweden, Norway, Finland, Denmark. Methods Primary diagnosed by oral pathologists from 2010 2020 at nine different diagnostic laboratories Denmark were identified. Using histopathology referrals their corresponding histopathological...
J Oral Pathol Med (2012) 41 : 741–747 Background: The role of Toll‐like receptors (TLRs) has been elucidated in many human infectious, autoimmune and neoplastic diseases. Previously, TLR2 TLR4 expression oral lichen planus (OLP) was described. aim our study to examine patterns TLR9 normal mucosa OLP describe the effect topical tacrolimus treatment on OLP. Methods: receptor 4 analysed by immunohistochemistry five samples 50 (31 representing clinically white 19 erythematous/erosive lesions)....
Matrix metalloproteinase‐8 (MMP‐8) participates in skin wound healing and inflammation. We hypothesized that MMP‐8 plays a role after tooth extraction periapical Bone formation, collagen metabolism, inflammation socket lesions were analyzed wild‐type mice MMP‐8‐deficient (MMP‐8 −/− ) mice. New trabecular bone area the sockets similar both groups. In significantly more type III procollagen was synthesized, neutrophil MMP‐9 levels lower The amount of Fas ligand, identified as substrate for...
Abstract Background Oral lichen planus (OLP) is a chronic T‐cell‐mediated inflammatory disease, which associated with increased risk of developing oral squamous cell carcinoma. Epithelial‐to‐mesenchymal transition physiological phenomenon occurring during growth and organogenesis, but it has also an important role in tumorigenesis. In the present work, we studied expression known epithelial‐to‐mesenchymal markers planus. Methods total, 54 22 control samples were analyzed for markers. Samples...
Abstract Several quantitative studies have sought to determine the factors affecting unauthorized copying of software, particularly in North America. However, we find no statistically reliable on situation Europe. In order address this gap literature, explored attitudes and computer software 249 Finnish university students: nine hypotheses derived from existing research or theories ethics were tested. A questionnaire was used as instrument. The results shed new light characteristics users...
Abstract Background Oral erythroplakia (OE) is a rare oral potentially malignant disorder, that has high rate of transformation. The definition OE still lacks uniformity. In particular, lesions look clinically like erythroplakias, but are histopathologically diagnosed as squamous cell carcinomas sometimes called erythroplakias. purpose this study to present demographic and clinicopathologic features series OEs -like (OELSCC), their differences discuss the OE. Methods A multicenter...
Angiokeratoma is a rare, cutaneous vascular disorder that can occur in several clinically distinct conditions. It usually presents as multiple, red to blue or black, asymptomatic papules on the skin. Oral mucosal involvement common systemic form, but very rare localized forms of angiokeratomas. We report second case solitary papular angiokeratoma oral cavity.
A role for incisional biopsy in preoperative prognostication is increasingly being advocated oral tongue squamous cell carcinomas (OTSCC). Biopsies at two locations were compared, and prognostic factors biopsies their corresponding resections evaluated. total of 138 OTSCC slides from Finland Saudi Arabia compared size (horizontal vertical) invasive front. The Finnish cases assessed tumor stroma ratio (TSR) tumor‐infiltrating lymphocytes (TILs) using light microscopy digital image analysis...
Background Oral lichen planus ( OLP ) is an idiopathic T‐cell‐mediated mucosal inflammatory disease. Cathepsin K (Cat K) one of the lysosomal cysteine proteases. It involved in many pathological conditions, including osteoporosis and cancer. The expression role Cat are unknown. Methods Twenty‐five oral specimens diagnosed histopathologically as fourteen healthy controls HC were used to study immunohistochemical IHC K. Colocalization with CD 1a, Melan‐A, 68, 45, mast cell tryptase MCT ),...
Oral mucosal dysplasia is a histologic feature of potentially malignant disorders that associated with the risk transformation to carcinoma. Dysplastic cells use many strategies during their cancer, including escape from immune mediated destruction. We hypothesized adaptive immunity inhibited by activation distinct checkpoint molecules, such as indoleamine 2,3-dioxygenase 1 (IDO1) and programmed death-ligand (PD-L1).We collected 63 oral samples 47 patients. Nine biopsies alveolar mucosa were...
Background Oral lichen planus (OLP) is an immune‐mediated mucosal disease of unclear etiology and unresolved pathogenesis. Hyaluronan (HA) extracellular matrix glycosaminoglycan involved in inflammation tumor progression. However, its presence OLP has not been reported. We therefore aimed to study the immunohistochemical expression HA, receptor CD44, hyaluronan synthases (HAS1‐3), hyaluronidases (HYAL1‐2) OLP. Methods The HAS1‐3, HYAL1‐2 was studied by methods 55 23 control oral specimens...
Objective: An association between hypothyroidism (HT) and oral lichen planus (OLP) has been reported. However, the mechanisms that could explain this remain unresolved. This study aimed to evaluate expression of thyroid-stimulating hormone (TSH) receptor (TSHR) in healthy mucosa OLP lesions individuals with without HT.Material methods: Immunohistochemical TSH TSHR was studied mucosal biopsies obtained from 14 patients HT, HT 10 controls lesions. Gene investigated by using three different PCR...