A5026375253- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Extracellular vesicles in disease
- Genetics, Aging, and Longevity in Model Organisms
- Photosynthetic Processes and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Enzyme Structure and Function
- Microtubule and mitosis dynamics
- Metabolomics and Mass Spectrometry Studies
- Algal biology and biofuel production
- thermodynamics and calorimetric analyses
- Caveolin-1 and cellular processes
- Heat shock proteins research
- Advanced biosensing and bioanalysis techniques
- Cellular Mechanics and Interactions
CIC bioGUNE
2022-2025
Ludwig-Maximilians-Universität München
2018-2023
Urologische Klinik München
2019
The induction of the mitochondrial unfolded protein response (UPRmt) results in increased transcription gene encoding chaperone HSP70. We systematically screened C. elegans genome and identified 171 genes that, when knocked down, induce expression an hsp-6 HSP70 reporter encode proteins. These represent many, but not all, processes (e.g., calcium homeostasis mitophagy are represented). Knockdown these leads to reduced membrane potential and, hence, decreased import into mitochondria. In...
ABSTRACT Alzheimer´s disease (AD) is the most frequent neurodegenerative disorder in world and characterised by loss of memory other cognitive functions. Metabolic changes associated with AD are important players development disease. However, mechanism underlying these still unknown. Extracellular vesicles (EVs) nano‐sized particles that play an role regulating pathophysiological processes a non‐invasive manner to obtain information cell secreting them. The analysis brain‐derived EVs (bdEVs)...
Abstract Circulating cell‐free nucleic acids are considered a promising source of biomarkers for diseases and cancer. Liquid biopsy brain tumours represent major, still unmet, clinical need. In plasma, can be free or associated with extracellular vesicles (EVs). Here we report an easy reproducible method to analyse in plasma EVs by conventional flow cytometry translate into the clinics. Nucleic present samples stained Pyronin Y, which is fluorescent dye that preferably binding...
Maintaining organelle function in the face of stress is known to involve organelle-specific retrograde signaling. Using Caenorhabditis elegans, we present evidence existence such signaling for peroxisomes, which define as peroxisomal (PRS). Specifically, show that import caused by knockdown matrix receptor prx-5/PEX5 triggers NHR-49/peroxisome proliferator activated alpha (PPARα)- and MDT-15/MED15-dependent upregulation Lon protease lonp-2/LONP2 catalase ctl-2/CAT. proteomic transcriptomic...
During cytokinesis, a contractile ring consisting of unbranched filamentous actin (F-actin) and myosin II constricts at the cell equator. Unbranched F-actin is generated by formin, without formin no cleavage furrow forms. In Caenorhabditis elegans, depletion septin restores ingression in mutants. How ingresses detectable unknown. We report that, this setting, anillin (ANI-1) forms meshwork circumferentially aligned linear structures decorated non-muscle (NMY-2). Analysis ANI-1 deletion...
The induction of the mitochondrial unfolded protein response (UPRmt) results in increased transcription gene encoding chaperone HSP70. We systematically screened C. elegans genome and identified 172 genes that, when knocked-down, induce expression an hsp-6 HSP70 reporter encode proteins. These represent many, but not all, processes. For example, calcium homeostasis mitophagy are represented. When compromised, processes that represented UPRmt a manner is dependent on factor ATFS-1, kinase...
Distinct retrograde signaling pathways have been identified for several cellular organelles. These are important to maintain the function of these organelles in response organelle-specific stress. Using Caenorhabditis elegans, we show first time that such a also exists peroxisomes. Specifically, peroxisomal import stress caused by knock-down matrix protein receptor prx-5/PEX5 triggers NHR-49/PPARα dependent transcriptional up-regulation Lon protease lonp-2/LONP2 and catalase ctl-2/CAT. We...
Abstract During cytokinesis a contractile ring consisting of unbranched filamentous actin (F-actin) and myosin II filaments assembles constricts at the cell equator. Unbranched F-actin is de novo generated by formin without cleavage furrow ingression fails. In C. elegans depletion septin restores in (CYK-1) mutants. How ingresses detectable not known. We report, that this setting anillin (ANI-1) essential for forms meshwork linear structures, which circumferentially align around Although...