A5078306266- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Viral-associated cancers and disorders
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Head and Neck Surgical Oncology
- Renal cell carcinoma treatment
- Cytomegalovirus and herpesvirus research
- Cancer and Skin Lesions
- Metastasis and carcinoma case studies
- Urologic and reproductive health conditions
- Renal and related cancers
- Chronic Lymphocytic Leukemia Research
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2014-2024
Fundação Oswaldo Cruz
2024
CTO Andrea Alesini
2024
Azienda Ospedaliera Sant'Andrea
2023-2024
IRCCS Humanitas Research Hospital
2023
University of Turin
1993-2015
Azienda Ospedaliero Universitaria Maggiore della Carita
2011-2015
Azienda Ospedaliero Universitaria San Giovanni Battista
1990-2015
Ospedale Maggiore
2005-2006
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2005-2006
The mechanisms responsible for the evolution of steatosis towards NASH (non-alcoholic steatohepatitis) and fibrosis are not completely defined. In present study we evaluated role CD4(+) T-helper (Th) cells in this process. We analysed infiltration different subsets Th C57BL/6 mice fed on a MCD (methionine choline-deficient) diet, which is model reproducing all phases human progression. There was an increase Th17 at beginning development NASH-fibrosis transition, whereas levels Th22 peaked...
Abstract Interferon‐γ (IFN‐γ) is produced by activated T lymphocytes and plays a regulatory role in immune responses. The nature location of cells that express the IFN‐γ receptor (R) respond to this lymphokine are not well documented. distribution human IFN‐γ‐R (HuIFN‐γ‐R) was, therefore, investigated situ immunohistochemistry, using affinity‐purified rabbit polyclonal antibodies directed against extracellular domain receptor. In lymphoid organs, expression restricted B cell areas lymph...
Background. Apocrine carcinomas of the skin are rare and incompletely studied neoplasms. Methods. An immunohistochemical ultrastructural study is reported specimens from six patients with apocrine carcinoma in various body sites. Three tumors were axilla; one, eyelid; ear; scalp. There three local recurrences regional lymph node metastases, but no patient died cancer (follow-up, 2–10 years). Results. The most reliable histopathologic criteria for identifying appear to be decapitation...
Ischemia/reperfusion (I/R) injury is an important cause of acute renal failure because oxidative, inflammatory, and apoptotic mechanisms. The aim the present study was to examine any possible protective effects levosimendan in vivo pig model I/R injury. In 40 anesthetized pigs (eight groups five each), induced by clamping-reopening left artery. During ischemia, three pigs, multiorgan preservation solution Custodiol, alone or combination with levosimendan, were infused two other animals,...
Abstract Autophagy is a lysosomal-driven catabolic process that contributes to preserve cell and tissue homeostases through the regular elimination of damaged, aged redundant self-constituents. In normal cells, autophagy protects from DNA mutation carcinogenesis by preventive pro-oxidative mitochondria protein aggregates. Mutations in oncogenes oncosuppressor genes dysregulate autophagy. Up-regulated may confer chemo- radio-resistance cancer also pro-survival advantage cells experiencing...
Autophagy is dysregulated in cancer and might be involved ovarian carcinogenesis. BECLIN-1, a protein that interacts with either BCL-2 or PI3k class III, plays critical role the regulation of both autophagy cell death. Induction associated presence vacuoles characteristically labelled LC3. We have studied biological clinical significance BECLIN 1 LC3 ovary tumours different histological types. The positive expression was well correlated LC3-positive autophagic inversely BCL-2. latter...
Psoriasis is a common cutaneous disorder characterized by abnormal epidermal differentiation, proliferation and inflammation mediated dermal infiltrates, such as T cells, neutrophils, dendritic cells macrophages. There are renewed interest in the role of components innate immune system. Cytokines tumor necrosis factor-alpha (TNF-alpha) interleukin (IL)-6, -1beta involved pathogenic phenomena psoriasis known inducers acute phase response. Among large group reactants, C-reactive protein (CRP)...
A large fraction of factor VIII in blood originates from liver sinusoidal endothelial cells although extrahepatic sources also contribute to plasma levels. Identification cell-types other than with the capacity synthesize and release will be helpful for therapeutic approaches hemophilia A. Recent cell therapy bone marrow transplantation studies indicated that Küpffer cells, monocytes mesenchymal stromal could sufficient amount ameliorate bleeding phenotype hemophilic mice. To further...
Hemophilia A (HA) is an X-linked bleeding disease caused by factor VIII (FVIII) deficiency. We previously demonstrated that FVIII produced specifically in liver sinusoid endothelial cells (LSECs) and to some degree myeloid cells, thus, the present work, we seek restrict expression of transgene these using cell-specific promoters. With this approach, aim limit immune response a mouse model lentiviral vector (LV)-mediated gene therapy encoding FVIII. To increase target specificity expression,...
Biomimetic magnetic nanoparticles mediated by magnetosome proteins (BMNPs) are potential innovative tools for cancer therapy since, besides being multifunctional platforms, they can be manipulated an external gradient field (GMF) and/or alternating (AMF), mediating targeting and hyperthermia, respectively. We evaluated the cytocompatibility/cytotoxicity of BMNPs Doxorubicin (DOXO)-BMNPs in presence/absence GMF 4T1 MCF-7 cells as well their cellular uptake. analyzed biocompatibility vivo...
Abstract Among all cancers, colorectal cancer (CRC) is the 3rd most common and 2nd leading cause of death worldwide. New therapeutic strategies are required to target stem cells (CSCs), a subset tumor highly resistant present-day therapy responsible for relapse. CSCs display dynamic genetic epigenetic alterations that allow quick adaptations perturbations. Lysine-specific histone demethylase 1A (KDM1A also known as LSD1), FAD-dependent H3K4me1/2 H3K9me1/2 demethylase, was found be...
Germline mutations in the tyrosine-kinase domain of MET proto-oncogene were found patients suffering from hereditary predisposition to develop multiple papillary renal-cell carcinomas (hereditary PRCC, HPRCC). PRCCs are often and bilateral even without a family history. We analyzed germline carrying or single tumors with One patient had familial cancer carried novel (V1110I) mutation, located gene exon 16. This mis-sense mutation was affected members this patient's family. Interestingly,...
The course of mouse cytomegalovirus (MCMV) infection was compared between wild-type and mutant C57BL / 6 (B6) mice deficient in either RAG-2, perforin, granzyme A, B or combinations thereof at two time points post (p. i.). At day 15 p. i., virus titers were similarly elevated salivary glands all mutant, but not B6 undetectable lung spleen tissues any the strains. Significant pathological alterations only seen from RAG2– –, those other whereas few inflammatory foci observed except B6. 30...
Abstract Objective The percentage of patients with thyroid cancer incidentally diagnosed during a 18 F‐fluorodeoxyglucose Positron Emission Tomography computed tomography (CT) (FDG‐PET/CT) for nonthyroid diseases ranges between 26% and 50%. Design Retrospective assessment the clinical pathological features incidentalomas at FDG‐PET/CT, aiming to identify potential predictors malignancy. Patients Fifty‐two incidental uptake FDG‐PET/CT were retrospectively included [38 W, age 64·1 ± 12·5 years...
As in other organs, oxidative stress-induced injury and cell death may result from free oxygen radical-dependent mechanisms alterations signal transduction pathways leading to apoptosis. Among the new suggested therapies for injuries caused by stress, use of levosimendan has been reported be quite promising. In present study, we aimed examine protective effects against liver stress anesthetized rats analyze involvement mitochondrial adenosine triphosphate-dependent potassium (mitoK(ATP))...
NEFA (non-esterified 'free' fatty acid)-mediated lipotoxicity plays a critical role in the pathogenesis of NASH (non-alcoholic steatohepatitis). In light growing need for new therapeutic options NASH, we investigated action A2aR (adenosine A(2a) receptor) stimulation against lipotoxicity. The effects A(2a)R agonist CGS21680 [2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxyamidoadenosine] were evaluated 'in vitro' liver cells exposed to SA (stearic acid) and vivo' rats with induced by 8...