A5002952053- Geomagnetism and Paleomagnetism Studies
- Calcium Carbonate Crystallization and Inhibition
- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Magnetic and Electromagnetic Effects
- Minerals Flotation and Separation Techniques
- Geochemistry and Elemental Analysis
- Building materials and conservation
- Bone Tissue Engineering Materials
- Iron oxide chemistry and applications
- Geology and Paleoclimatology Research
- Enzyme Structure and Function
- Paleontology and Stratigraphy of Fossils
- Microbial Applications in Construction Materials
- Nanoplatforms for cancer theranostics
- Groundwater and Isotope Geochemistry
- Bacterial biofilms and quorum sensing
- Microfluidic and Bio-sensing Technologies
- Animal Nutrition and Physiology
- Planetary Science and Exploration
- Diatoms and Algae Research
- Salmonella and Campylobacter epidemiology
- Moringa oleifera research and applications
- Electrospun Nanofibers in Biomedical Applications
- Antimicrobial Peptides and Activities
Universidad de Granada
2016-2025
Czech Academy of Sciences, Institute of Microbiology
2017
Instituto Andaluz de Ciencias de la Tierra
2013
Estación Experimental del Zaidín
2001-2006
Savannah River National Laboratory
2001-2006
University of Georgia
2001-2006
Consejo Superior de Investigaciones Científicas
2001
Purpose: The lack of specificity conventional chemotherapy is one the main difficulties to be solved in cancer therapy. Biomimetic magnetoliposomes are successful controlled-release systems, hyperthermia, and active targeting agents by functionalization their surface with monoclonal antibodies. membrane receptor Leucine-rich repeat-containing G-protein coupled 5 (LGR5) stands out as colorectal (CRC) biomarker appears related treatment resistance development metastasis. aim this study was...
Several mechanisms have been proposed to explain the interactions between proteins and mineral surfaces formed during biomineralization. To investigate effect of surface charge on calcium carbonate precipitation, a group globular with similar sizes molecular weights but different isoelectric points (iep) has selected be added CaCl2 solution in free-drift precipitation experiments. These are lysozyme (Lyz; theoretical iep 9.32), ribonuclease-A (Rib-A; 8.64), myoglobin (Myo; 7.36),...
New biomimetic magnetite nanoparticles (hereafter BMNPs) with sizes larger than most common superparamagnetic were produced in the presence of recombinant MamC protein from Magnetococcus marinus MC-1 and functionalized doxorubicin (DOXO) intended as potential drug nanocarriers. Unlike inorganic nanoparticles, BMNPs controls their size morphology, providing them magnetic properties consistent a large moment per particle; moreover, it provides novel surface properties. display isoelectric...
Biomimetic magnetic nanoparticles mediated by magnetosome proteins (BMNPs) are potential innovative tools for cancer therapy since, besides being multifunctional platforms, they can be manipulated an external gradient field (GMF) and/or alternating (AMF), mediating targeting and hyperthermia, respectively. We evaluated the cytocompatibility/cytotoxicity of BMNPs Doxorubicin (DOXO)-BMNPs in presence/absence GMF 4T1 MCF-7 cells as well their cellular uptake. analyzed biocompatibility vivo...
Immobilization of enzymes has been extensively required in a wide variety industrial applications as way to ensure functionality and the potential enzyme recycling after use. In particular, immobilization on magnetic nanoparticles (MNPs) could offer reusability by means recovery concentration, along with increased stability robust activity under different physicochemical conditions. present work, microbial α-amylase (AmyKS) xylanase (XAn11) were both immobilized types MNPs [MamC-mediated...
Conventional chemotherapy against colorectal cancer (CRC), the third most common in world, includes oxaliplatin (Oxa) which induces serious unwanted side effects that limit efficiency of treatment. Therefore, alternative therapeutic approaches are urgently required. In this work, biomimetic magnetic nanoparticles (BMNPs) mediated by MamC were coupled to Oxa evaluate potential Oxa-BMNP nanoassembly for directed local delivery drug as a proof concept future development targeted CRC....
In this work we report on the synthesis and characterization of magnetic nanoparticles two distinct origins, one inorganic (MNPs) other biomimetic (BMNPs), latter based a process bacterial synthesis. Each these kinds particles has its own advantages when used separately with biomedical purposes. Thus, BMNPs present an isoelectric point below neutrality (around pH 4.4), while MNPs show zero-zeta potential at 7, appear to be excellent agents for hyperthermia. This means that are better suited...
Mineralized structures generated under biological control are hierarchical composites that consist of biopolymer matrices and minerals. The matrix in material is developed as membranes or a network fibrils, which has structural well functional roles for the composite hard tissue. Microorganisms surrounded by microbial extracellular polymeric substances (EPS), self-organized macromolecules have fibrous fabric. EPS enables survival microorganisms with their modes organization different...