A5013564838- Methane Hydrates and Related Phenomena
- Hydrocarbon exploration and reservoir analysis
- Microbial Community Ecology and Physiology
- Medical and Health Sciences Research
- Genomics and Phylogenetic Studies
- Traumatic Ocular and Foreign Body Injuries
- CO2 Sequestration and Geologic Interactions
- Pelvic and Acetabular Injuries
- Immune Response and Inflammation
- Animal Ecology and Behavior Studies
- Glaucoma and retinal disorders
- Orthopaedic implants and arthroplasty
- Metabolomics and Mass Spectrometry Studies
- Bone and Joint Diseases
- Pregnancy-related medical research
- Spinal Fractures and Fixation Techniques
- Geological and Geochemical Analysis
- Groundwater and Isotope Geochemistry
- Hip disorders and treatments
- Atmospheric chemistry and aerosols
- Geology and Paleoclimatology Research
- Intraocular Surgery and Lenses
- Maritime and Coastal Archaeology
- Geochemistry and Geologic Mapping
- Biomedical Research and Pathophysiology
Colorado School of Mines
2018-2023
University of Colorado Boulder
2022-2023
Tulane University
2023
NASA Astrobiology Institute
2019
Hôpital régional
2009
Réseau Fribourgeois de Santé Mentale
2006
University of Illinois Urbana-Champaign
1990
Kiel University
1989
Augenklinik Heidelberg
1968-1973
Goethe University Frankfurt
1960
Abstract Hydration of ultramafic rock during the geologic process serpentinization can generate reduced substrates that microorganisms may use to fuel their carbon and energy metabolisms. However, serpentinizing environments also place multiple constraints on microbial life by generating highly hyperalkaline waters are limited in dissolved inorganic carbon. To better understand how persists under these conditions, we performed geochemical measurements from a environment subjected planktonic...
Abstract The Oman Drilling Project established an “Active Alteration” multi‐borehole observatory in peridotites undergoing low‐temperature serpentinization the Samail Ophiolite. highly serpentinized rocks are contact with strongly reducing fluids. Distinct hydrological regimes, governed by differences rock porosity and fracture density, give rise to steep redox (Eh +200 −750 mV) pH (pH range 8.5–11.2) gradients within 300–400 m deep boreholes. serpentinites fluids host active subsurface...
Little is known of acetogens in contemporary serpentinizing systems, despite widely supported theories that serpentinite-hosted environments the first life on Earth via acetogenesis. To address this knowledge gap, genome-resolved metagenomics was applied to subsurface fracture water communities from an area active serpentinization Samail Ophiolite, Sultanate Oman. Two deeply branching putative bacterial acetogen types were identified belonging Acetothermia (hereafter, I and II) exhibited...
Abstract Metagenome assembled genomes (MAGs) and single amplified (SAGs) affiliated with two distinct Methanobacterium lineages were recovered from subsurface fracture waters of the Samail Ophiolite, Sultanate Oman. Lineage Type I was abundant in circumneutral pH, whereas lineage II hydrogen rich, hyperalkaline waters. encoded proteins to couple oxidation CO2 reduction, typical hydrogenotrophic methanogens. Surprisingly, II, which branched lineage, lacked homologs key oxidative...
Serpentinization can generate highly reduced fluids replete with hydrogen (H2) and methane (CH4), potent reductants capable of driving microbial methanogenesis methanotrophy, respectively. However, CH4 in serpentinized waters is thought to be primarily abiogenic, raising key questions about the relative importance methanogens methanotrophs production consumption these systems. Herein, we apply molecular approaches examine functional capability activity cycling serpentinization-impacted...
Abstract The role of lithospheric heterogeneities, presence or absence melt, local and regional stresses, gravitational potential energy in strain localization continental rifts remains debated. We use new seismic geodetic data to identify the location orientation modern Nubia‐Somalia plate boundary 300‐km‐wide zone between southern Main Ethiopian Rift (MER) Eastern (ER) across Mesozoic Anza rift Turkana Depression. This region exhibits heterogeneity, 45 Ma‐Recent magmatism, more than 1,500...
Hot spring environments can create physical and chemical gradients favorable for unique microbial life. They also include authigenic mineral precipitates that may preserve signs of biological activity on Earth possibly other planets. The abiogenic or biogenic origins such be difficult to discern, therefore a better understanding formation processes is critical the accurate interpretation biosignatures from hot springs. Little Creek (LHC) complex located in Long Valley Caldera, California,...
Nitrogen (N) is an essential element for life. N compounds such as ammonium ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:msubsup><mml:mrow><mml:mtext>NH</mml:mtext></mml:mrow><mml:mrow><mml:mn>4</mml:mn></mml:mrow><mml:mrow><mml:mo>+</mml:mo></mml:mrow></mml:msubsup></mml:math> ) may act electron donors, while nitrate...
Mit Hilfe des Parabioseversuches läßt sich die Nephrotoxin-(Masugi-) Nephritis der Ratte in derselben Weise wie bei Verwendung genetisch differenter Tiere auch auf Inzuchtratten übertragen. Dieses Resultat weist darauf hin, daß genetische Inkompatibilitäten im Sinne „Transplantationsimmunität“ vorliegenden Übertragung keine Rolle spielen. Die Übertragungsreaktion muß vielmehr als Folge Einwirkung Blutes nierenkranker gesundes Nierengewebe angesehen werden.
A 49-year-old man with a benign type of cystinosis exhibited crystalline deposits limited to the cornea and conjunctiva both eyes. These could be identified as cystine by histological, chromatographic, roentgenographic methods. The patient also suffered from syringomyelia. lamellar keratoplasty on left, formerly injured eye has been kept clear for 17 months shows practically no deposits. Similar alterations in other members family excluded.
Mit Hilfe des Parabioseversuchs läßt sich die Nephrotoxin-Masugi-Nephritis der Ratte sowohl bei genetisch differenten als auch Inzuchtratten auf primär gesunde Parabionten übertragen. Darüber hinaus kommt es „chronischer“ Nephritis nierenkranken zur Übertragung Nierenentzündung den gesunden Partner. Dabei entsprechen Nierenveränderungen nierengesunden dem morphologischen Bild einer „akuten“ Nephritis, im Gegensatz zu durch Zellverminderung auffallenden Befunden chronisch Tieren mit...
Airborne murine coronavirus was assessed for its sensitivity to the vapors of chemicals commonly used disinfect indoor surfaces. As a model chemical airborne SARS-CoV-2, infectious potential Mouse Hepatitis Virus (MHV) tracked in presence following pure vapors, each which below permissible exposure limit (PEL) as regulated by US National Institute Occupational Safety and Health (NIOSH): <50 ppmv glycol; <1ppmv HOCl; H2O2. Along with growth media, MHV aerosolized particle size distribution...
The process of serpentinization supports life on Earth and gives rise to the habitability other worlds in our Solar System. While numerous studies have provided clues survival strategies microbial communities serpentinizing environments modern Earth, characterizing activity such remains challenging due low biomass extreme conditions. Here, we used an untargeted metabolomics approach characterize dissolved organic matter groundwater Samail Ophiolite, largest best characterized example...
The generation of hydrogen and reduced carbon compounds during serpentinization provides sustained energy for microorganisms on Earth, possibly other extraterrestrial bodies (e.g., Mars, icy satellites). However, the geochemical conditions that arise from water-rock reaction also challenge known limits microbial physiology, such as hyperalkaline pH, limited electron acceptors inorganic carbon. Because cell membranes act a primary barrier between its environment, lipids are vital component in...
The Oman Drilling Project established an “Active Alteration” multi-borehole observatory in dunite and harzburgite undergoing low-temperature serpentinization the Samail ophiolite. highly serpentinized rocks are contact with strongly reducing fluids. Distinct hydrological regimes, governed by differences rock porosity fracture density, give rise to steep redox (Eh +200 -750 mV) pH (pH range 8.5 11.2) gradients within 300 400 meter deep boreholes. serpentinites fluids host active subsurface...