A5007957788- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Obstructive Sleep Apnea Research
- Cardiovascular and exercise physiology
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Heart Rate Variability and Autonomic Control
- Asthma and respiratory diseases
- Muscle activation and electromyography studies
- Sports Performance and Training
- Exercise and Physiological Responses
- Cardiovascular and Diving-Related Complications
- Cardiovascular Syncope and Autonomic Disorders
- Airway Management and Intubation Techniques
- Nutrition and Health in Aging
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
- Sports injuries and prevention
- Cardiac Arrest and Resuscitation
- Sleep and related disorders
- Cardiac Health and Mental Health
- Family and Patient Care in Intensive Care Units
- Antifungal resistance and susceptibility
University at Buffalo, State University of New York
2016-2025
VA Western New York Healthcare System
2014-2024
Buffalo VA Medical Center
2005-2021
Veterans Health Administration
2003-2019
Jiangsu Province Hospital
2017
Summa Health System
2017
Grady Memorial Hospital
2017
Emory University
2017
Nanjing Medical University
2017
New York University
2016
There is uncertainty about the interpretation of changes in 6-min walk distance (6MWD) chronic obstructive pulmonary disease (COPD) patients and whether minimal important difference (MID) for this useful outcome measure exists. Data were used from nine trials enrolling a wide spectrum COPD with 6MWD at baseline follow-up to determine threshold values using three distribution-based methods. Anchor-based methods MID also evaluated. included 460 mean± sd forced expiratory volume one second (FEV...
Improving a patient's ability to self-monitor and manage changes in chronic obstructive pulmonary disease (COPD) symptoms may improve outcomes.To determine the efficacy of comprehensive care management program (CCMP) reducing risk for COPD hospitalization.A randomized, controlled trial comparing CCMP with guideline-based usual care. (ClinicalTrials.gov registration number: NCT00395083) SETTING: 20 Veterans Affairs hospital-based outpatient clinics.Patients hospitalized past year.The included...
We evaluated whether contractile fatigue of the quadriceps occurs after cycling exercise in patients with chronic obstructive pulmonary disease (COPD) and it could contribute to limitation. Eighteen COPD performed two constant work-rate exercises up exhaustion. These tests were preceded by nebulization placebo or 500 μg ipratropium bromide. Muscle was defined as a postexercise reduction twitch force more than 15% resting value. There an increase endurance time postipratropium compared (440 ±...
Studies of breathing pattern have focused primarily on changes in the mean values components, whereas there has been minimal investigation breath-to-breath variability, which should provide information constancy with respiration is controlled. In this study we examined variability both a and day-to-day basis by calculating coefficient variation (i.e., standard deviation expressed as percentage mean). By examining data, found that coefficients tidal volume (VT) fractional inspiratory time...
Abstract Recent data suggest that the potentiated twitch is a more sensitive index of contractile fatigue than unpotentiated twitch. We hypothesized after potentially fatiguing load, fall in amplitude would be significantly greater an compared response and twitches to series loads using magnetic stimulation femoral nerve 10 healthy subjects. The baseline quadriceps force (TwQu), (TwQp), maximal voluntary contraction (MVC) were 129 ± 6 N, 198 622 25 respectively. During protocol was designed...
The purpose of this study was to determine whether induction inspiratory muscle fatigue might impair subsequent exercise performance. Ten healthy subjects cycled volitional exhaustion at 90% their maximal capacity. Oxygen consumption, breathing pattern, and a visual analogue scale for respiratory effort were measured. Exercise performed on three separate occasions, once immediately after fatigue, whereas the other two episodes served as controls. Fatigue achieved by having breathe against an...
The purpose of this study was to determine whether diaphragmatic fatigue occurs after high-intensity constant-load whole-body exercise volitional exhaustion. Ten sedentary subjects with a maximal oxygen uptake 2.52 ± 0.47 L/min were studied. Subjects exercised on bicycle ergometer at 80% their working capacity until Minute ventilation during the last minute 89.9 13.6 L/min, which represented 50 6% subjects' 12-s voluntary ventilation. During exercise, mean inspiratory esophageal pressure...
We hypothesized that patients with chronic obstructive pulmonary disease developing contractile fatigue of the quadriceps during cycle exercise may have characteristic metabolic and muscle features could increase their susceptibility to fatigue, thus differentiating them from those who do not develop fatigue. examined, in 32 patients, fiber-type proportion, enzymatic activities, capillary density vastus lateralis arterial blood lactate level constant work-rate cycling exercise. Contractile...
We have recently shown that patients with chronic obstructive pulmonary disease (COPD) develop contractile fatigue of their quadriceps muscle following endurance exercise. Pulmonary rehabilitation can produce physiological adaptations in COPD. hypothesized if induces the exercising muscle, it should become more resistant. Twenty one COPD, mean age 69.9 ± 1.9 yr, FEV1 45 4% predicted, participated an 8-wk outpatient, supervised exercise program. Quadriceps was detected by a fall twitch force...
Respiratory muscle fatigue is considered a common cause of weaning failure but its detection hampered by the lack satisfactory diagnostic test. Abdominal paradox has been proposed as valuable clinical index and thus presence may lead to curtailment trials. However, sensitivity specificity this sign predictor outcome unknown. We hypothesize that abnormal ribcage-abdominal (RC-Ab) motion finding in early stages does not inevitably imply an unsuccessful outcome. tested hypothesis patients...
In Brief PURPOSE: The purpose of this study was to determine whether patients with chronic obstructive pulmonary disease (COPD) increase physical activity immediately after a short course (8 weeks) rehabilitation (PR). Activity levels in COPD were also compared those healthy controls. METHODS: Consecutive (n = 24, aged 71.9 ± 7.7 years, forced expiratory ventilation 1 second 44.1 17.9% predicted, who completed PR) and 8 aged-matched controls (aged 66.6 7.2 years) studied. monitored triaxial...
Patients with chronic obstructive pulmonary disease (COPD) are at a mechanical disadvantage and should be predisposed to the development of diaphragmatic fatigue when ventilatory system is stressed by exercise. The purpose this study was determine whether patients moderately severe COPD develop contractile diaphragm after cycle exercise limits tolerance. Twelve male COPD, age 61.4 ± 3.0 yr, participated. Their forced expiratory volume in 1 s (FEV1) 1.79 0.14 L, 49.6 3.4% predicted. cycled...
Patients with COPD have derangements in respiratory mechanics that may cause them to stop exercising before the limb muscles reach their functional limits. However, because lung disease makes activity unpleasant, patients chronic obstructive pulmonary (COPD) often adapt a sedentary lifestyle leading progressive deconditioning. Deconditioning will lead deterioration muscle function, which could adversely affect exercise capacity. The purpose of this study was determine whether fatigue...
The original chronic respiratory questionnaire (CRQ), one of the most widely used measures health-related quality life (HRQL) in disease (CRD), is traditionally interviewer administered (IA) and includes an individualised dyspnoea domain. present authors studied impact self-administered (SA) standardised questions on CRQ measurement properties. In a factorial design multicentre trial, 177 patients with CRD (mean age 67.7 yrs; mean forced expiratory volume second per cent predicted 44.6%)...
The purpose of this study was to compare quadriceps fatigability in patients with varying severity chronic obstructive pulmonary disease age-matched control subjects. Ten healthy subjects, 8 severe (FEV1 less than 35% predicted), and 11 mild moderate were studied. FEV1 1.75 +/- 0.13 L (SE), 50.4 2.9% predicted the group, 0.87 0.06 L, 25.9 1.9% group. Quadriceps fatigue quantified by reduction potentiated twitch force after a potentially fatiguing task. All subjects performed three sets 10...