A5064209823- RNA Research and Splicing
- Electronic Packaging and Soldering Technologies
- Cellular Mechanics and Interactions
- Nuclear Structure and Function
- RNA modifications and cancer
- Electron and X-Ray Spectroscopy Techniques
- RNA and protein synthesis mechanisms
- Aluminum Alloy Microstructure Properties
- Supercapacitor Materials and Fabrication
- Cell Adhesion Molecules Research
- Advancements in Battery Materials
- Advanced Materials Characterization Techniques
- Semiconductor materials and devices
- Protease and Inhibitor Mechanisms
- Advanced Battery Technologies Research
- Hydrogen embrittlement and corrosion behaviors in metals
- Genetics, Bioinformatics, and Biomedical Research
- Anodic Oxide Films and Nanostructures
- Genomics and Chromatin Dynamics
- Mathematics Education and Teaching Techniques
- Ionic liquids properties and applications
- Metallurgy and Material Forming
- Fuel Cells and Related Materials
- Microstructure and Mechanical Properties of Steels
- Genetics, Aging, and Longevity in Model Organisms
Sandia National Laboratories
1997-2022
Sandia National Laboratories California
2004-2015
The University of Sydney
2007-2012
MRC Laboratory of Molecular Biology
2001-2008
Medical Research Council
2008
John Radcliffe Hospital
1997
University of Oxford
1993-1997
Second‐phase particles in Al‐4.4Cu‐15Mg‐0.6 Mn (2024‐T3) were characterized by size and chemistry using scanning electron microscopy associated electron‐beam microanalysis methods. It was found that approximately 60% of greater than about 0.5 to 0.7 μm (the S phase). This fraction corresponded 2.7% the total surface area. phase appeared be active with respect matrix phase, consistent open‐circuit potentials reported literature for . The compound exhibited severe dealloying which resulted...
The β subunit cytoplasmic domains of integrin adhesion receptors are necessary for the connection these to actin cytoskeleton. protein, talin, binds tails and filaments, hence forming an integrin-cytoskeletal linkage. We used recombinant structural mimics β<sub>1</sub>A, β<sub>1</sub>D β<sub>3</sub>integrin characterize integrin-binding sites within talin. Here we report that site is localized N-terminal talin head domain. binding domain specific in it abrogated by a single point mutation...
article Free Access Share on Programming-languages as a conceptual framework for teaching mathematics Authors: W. Feurzeig View Profile , S. Papert M. Bloom R. Grant C. Solomon Authors Info & Claims ACM SIGCUE OutlookVolume 4Issue 2April 1970 pp 13–17https://doi.org/10.1145/965754.965757Online:01 April 1970Publication History 36citation936DownloadsMetricsTotal Citations36Total Downloads936Last 12 Months248Last 6 weeks30 Get Citation AlertsNew Alert added!This alert has been successfully...
The ninth and tenth type III domains of fibronectin each contain specific cell binding sequences, RGD in FIII10 PHSRN FIII9, that act synergistically mediating adhesion. We investigated the relationship between domain-domain orientation synergistic adhesive activity FIII9 pair domains. interdomain interaction FIII9-10 was perturbed by introduction short flexible linkers Incremental extensions link reduced initial attachment, but had a much more pronounced effect on downstream adhesion events...
Nuclear abundant poly(A) RNA-binding protein 2 (Nab2) is an essential yeast heterogeneous nuclear ribonucleoprotein that modulates both mRNA export and tail length. The N-terminal domain of Nab2 (residues 1-97) mediates interactions with the C-terminal globular pore-associated protein, myosin-like 1 (Mlp1), factor, Gfd1. solution crystal structures show a primarily helical fold analogous to PWI found in several other proteins. In contrast PWI-containing proteins, we find no evidence binds...
Although several models have been proposed to account for how cytoskeleton polymerization drives protrusion in cell motility, the precise mechanism remains controversial. Here, we show that, addition force exerted directly against membrane by growing filaments, way elongating filaments pack also contributes generating an expansion of gel. Tomography shows that filament packing major sperm protein (MSP) -based nematode sperm-motility machinery resembles observed with rigid rods. Maximum...
Abstract Many challenges must be overcome in order to create reliable electrochemical energy storage devices with not only high but also power densities. Gaps exist both battery and supercapacitor technologies, neither one satisfying the need for large densities a single device. To begin addressing these (and others), we report process self-assembled array of electrochemically active nanoparticles bound directly current collector using extremely short (2 nm or less) conductive tethers. The...
Journal Article Comparing Field Emission Electron Microprobe to Traditional EPMA for Analysis of Metallurgical Specimens Get access DF Susan, Susan Sandia National Laboratories, Albuquerque, New Mexico Search other works by this author on: Oxford Academic Google Scholar RP Grant, Grant JM Rodelas, Rodelas JR Michael, Michael MC Maguire Microscopy and Microanalysis, Volume 21, Issue S3, 1 August 2015, Pages 2107–2108, https://doi.org/10.1017/S1431927615011319 Published: 23 September 2015
ABSTRACT Recent reports have described transformation- and tumour-specific expression of fibronectin isoforms generated by alternative splicing the pre-mRNA. We investigated distribution EDIIIA+ EDIIIB+ splice variants in tumorigenic non-tumorigenic somatic cell hybrids made fusing fibrosarcoma-derived cells (HT1080) normal fibroblasts (GM00097). Alternative EDIIIA EDIIIB was assessed quantitatively S1 nuclease analyses. The levels mRNAs were similar parental hybrid cells. Domain-specific...