A5067658781- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Peripheral Artery Disease Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Cardiac Ischemia and Reperfusion
- Renal function and acid-base balance
- Antiplatelet Therapy and Cardiovascular Diseases
- Eicosanoids and Hypertension Pharmacology
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Anesthesia and Sedative Agents
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- Platelet Disorders and Treatments
- Intensive Care Unit Cognitive Disorders
- Cardiac tumors and thrombi
- Thermoregulation and physiological responses
- Research in Social Sciences
- Gastroesophageal reflux and treatments
- Airway Management and Intubation Techniques
- Heart Failure Treatment and Management
- Blood transfusion and management
Sahlgrenska University Hospital
2010-2024
University of Gothenburg
2016-2024
Russian Scientific Center of Surgery
2006
Helsinki University Hospital
2006
Norwegian University of Science and Technology
2006
Charles University
2006
Institute for Postgraduate Medical Education
2006
The beneficial effects of vasopressin on diuresis and creatinine clearance have been demonstrated when used as an additional/alternative therapy in catecholamine-dependent vasodilatory shock. A detailed analysis the renal perfusion, glomerular filtration, excretory function oxygenation man is, however, lacking. objective this pharmacodynamic study was to evaluate low moderate doses blood flow (RBF), filtration rate (GFR), oxygen consumption (RVO2) extraction (RO2Ex) post-cardiac surgery...
To evaluate the potential differential effects of norepinephrine, an alpha1-, beta1-, and beta2-receptor agonist, to alpha1-agonist phenylephrine on jejunal mucosal perfusion, gastric-arterial PCO2 gradient, global splanchnic oxygen demand-supply relationship after cardiac surgery.A randomized, prospective, interventional crossover study.A university cardiothoracic intensive care unit.Ten patients were studied during propofol sedation mechanical ventilation uncomplicated coronary artery...
Background: Low to moderate doses of vasopressin have been used in the treatment cathecholamine‐dependent vasodilatory shock sepsis or after cardiac surgery. We evaluated effects on jejunal mucosal perfusion, gastric‐arterial p CO 2 gradient and global splanchnic oxygen demand/supply relationship patients with Methods: Eight mechanically ventilated patients, dependent norepinephrine maintain mean arterial pressure (MAP) ≥60 mmHg because septic/post‐cardiotomy multiple organ failure surgery,...
Recent experimental studies have shown that a norepinephrine-induced increase in blood pressure induces loss of plasma volume, particularly under increased microvascular permeability. We studied the effects variations mean arterial (MAP) on volume changes and systemic haemodynamics patients with vasodilatory shock.Twenty-one mechanically ventilated who required norepinephrine to maintain MAP > or =70 mmHg because septic/postcardiotomy shock were included. The dose was randomly titrated...
Patients with norepinephrine-dependent vasodilatory shock after cardiac surgery (n = 10) were compared uncomplicated postcardiac patients respect to jejunal mucosal perfusion, gastric-arterial PCO2 gradient, and splanchnic oxygen demand/supply relationship. Furthermore, the effects of norepinephrine-induced variations in MAP on these variables evaluated shock. Norepinephrine infusion rate was randomly sequentially titrated target MAPs 60, 75, 90 mmHg (0.25 ± 0.24, 0.37 0.21, 0.55 0.39 μg/kg...
Background Induction of general anaesthesia has been shown to cause haemodilution and an increase in plasma volume. The aim this study was evaluate whether prevention hypotension during induction could avoid haemodilution. Methods Twenty‐four cardiac surgery patients, 66 ± 10 years, were randomised receive either norepinephrine a dose needed maintain mean arterial blood pressure ( MAP ) at pre‐anaesthesia levels after or control group that received vasopressor if decreased below 60 mmHg. No...
Temporary arterial shunting is an established method to prevent tissue ischaemia. Although less established, might also be achieved through endovascular and hybrid techniques, known as endoshunting. Endoshunting offers advantages, for example, enabling minimally invasive access avoiding complete occlusion of the donor artery. In ex vivo bench test, volume flow in various interconnected endoshunt systems had been tested previously. This study aims investigate capacity best performing system...
Animal studies have suggested that autoregulation of intestinal blood flow is severely impaired during cardiopulmonary bypass (CPB). We investigated the jejunal mucosal capacity to autoregulate perfusion nonpulsatile CPB (34 degrees C) in 10 patients undergoing elective cardiac surgery. Changes mean arterial pressure (MAP) were induced by altering rate randomly for periods 3 min from 2.4 L/min/m2 either 1.8 or 3.0 L/min/m2. Jejunal (JMP) was continuously recorded laser Doppler flowmetry. A...
Background: An imbalance between splanchnic oxygen supply and demand occurs during cardiopulmonary bypass (CPB) in man, which might disrupt the intestinal mucosal barrier function. The aim of present study was to evaluate effects mild hypothermic CPB on perfusion man undergoing cardiac surgery. Additionally we aimed identify variables, independently could predict changes microcirculatory variables CPB. Methods: Jejunal (JMP), jejunal hematocrit (JMHt), red blood cell (RBC) velocity...
Arterial haematocrit (Hct) has been shown to decrease after anaesthesia induction, most probably because of an increased plasma volume (PV). The primary objective was quantify change in PV if mean arterial pressure (MAP) kept at baseline level or allowed 60 mm Hg. Our secondary evaluate underlying mechanisms this response.Twenty-four coronary artery bypass patients were randomized a higher (90 Hg, intervention group) lower (60 control MAP by titration norepinephrine. During the experimental...
Background Administration of agents that enhance platelet reactivity may reduce the perioperative bleeding risk in patients treated with adenosine diphosphate (ADP)-receptor antagonist ticagrelor. Adrenaline potentiates ADP-induced aggregation and activation blood samples from ticagrelor-treated patients, but it has not previously been evaluated vivo. Methods Ten healthy male subjects were included an interventional study. A loading dose ticagrelor (180 mg) was administered, followed 2 hours...
Acute kidney injury is a well-known complication after cardiac surgery and cardiopulmonary bypass (CPB). In this experimental animal study, we evaluated the effects of atrial natriuretic peptide (ANP) on renal function, perfusion, oxygenation tubular during CPB.Twenty pigs were blindly randomized to continuous infusion either ANP (50 ng/kg/min) or placebo before, CPB. Renal blood flow as well cortical medullary perfusion was measured. Blood repeatedly sampled from vein. Glomerular filtration...
Temporary arterial shunting is an established method to prevent tissue ischemia. Although less established, might also be achieved through endovascular and hybrid techniques, known as endoshunting. Endoshunting offers advantages, for example, avoiding complete occlusion of the donor artery minimally invasive access. In ex vivo bench test, we previously tested volume flow in various interconnected endoshunt systems. this previous study, a combination 8F Prelude Short Sheath introducer (Merit...
Ischaemia and reperfusion can result in permanent tissue damage. During complex open abdominal aortic surgery, transient clamping of the renovisceral arteries may be required to successfully complete vascular repair. Endovascular shunting (endoshunting) presents an alternative technique for managing such temporary ischaemia. This study aimed investigate performance endoshunting renal circulation a porcine model.
The atrial natriuretic peptide (ANP) released from the heart regulates intravascular volume and is suspected to increase capillary permeability. Contradictory results regarding ANP glycocalyx degradation have been reported. aim of this study was investigate if an infusion causes endothelial glycocalyx.Twenty pigs, pretreated with 250 mg methylprednisolone, were randomized receive either (50 ng/kg/min) (n = 10) or 0.9% NaCl during 60 min. Endothelial components (heparan sulphate proteoglycan...
Acute tissue ischaemia may arise due to arterial emergencies or during more complex vascular procedures and be mitigated by temporary shunting techniques. Endovascular (ES) techniques enable percutaneous access from the donor artery without need completely interrupt flow in artery. An endoshunt system also cover longer distances than most conventional shunts. The aim was investigate optimise rates different endovascular shunt systems.Step 1: capacity of ES configurations compared with a 9 Fr...
s: European Association of Cardiothoracic Anaesthesiologists; 17th Annual Meeting; Dublin, Ireland; June 12-15, 2002: Anaesthesia
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