A5085931334- Health and Medical Research Impacts
- interferon and immune responses
- Lipid metabolism and biosynthesis
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Biomedical and Engineering Education
- RNA Research and Splicing
- Diet and metabolism studies
- Science, Research, and Medicine
- Genetics, Bioinformatics, and Biomedical Research
- Telomeres, Telomerase, and Senescence
- Cancer-related gene regulation
- ATP Synthase and ATPases Research
- Immune Cell Function and Interaction
- Child Nutrition and Water Access
- Circadian rhythm and melatonin
- Sex and Gender in Healthcare
- Cellular Mechanics and Interactions
- Protein Degradation and Inhibitors
- Nuclear Issues and Defense
- Bioinformatics and Genomic Networks
- Lipid Membrane Structure and Behavior
- Advanced Proteomics Techniques and Applications
- Genetics, Aging, and Longevity in Model Organisms
Rockefeller University
2015
Severe influenza disease strikes otherwise healthy children and remains unexplained. We report compound heterozygous null mutations in IRF7, which encodes the transcription factor interferon regulatory 7, an child who suffered life-threatening during primary infection. In response to virus, patient's leukocytes plasmacytoid dendritic cells produced very little type I III interferons (IFNs). Moreover, dermal fibroblasts induced pluripotent stem cell (iPSC)-derived pulmonary epithelial reduced...
The COVID-19 pandemic has created additional challenges for mid-career investigators seeking new academic opportunities. JCB asked scientists to share their experiences of uprooting research careers and laboratories during the pandemic.
JCB asks early career investigators to share their experience launching a lab during the COVID-19 pandemic.
Forman-Kay provides key structural insights into the biological functions of intrinsically disordered proteins.
Gergely investigates the roles of centrosomes in mitosis and beyond.
Bear studies the role of actin and its regulation in cell motility.
Kornblihtt studies how gene expression is controlled in mammals and plants.