A5103442726- Aquaculture disease management and microbiota
- Cellular transport and secretion
- Glycosylation and Glycoproteins Research
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- Genetic and phenotypic traits in livestock
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aquaculture Nutrition and Growth
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Reproductive Physiology in Livestock
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Milk Quality and Mastitis in Dairy Cows
- Endoplasmic Reticulum Stress and Disease
- Fungal Plant Pathogen Control
- Ichthyology and Marine Biology
- Psoriasis: Treatment and Pathogenesis
- Antifungal resistance and susceptibility
- PARP inhibition in cancer therapy
- Ruminant Nutrition and Digestive Physiology
- Autophagy in Disease and Therapy
- Glioma Diagnosis and Treatment
- Skin and Cellular Biology Research
- Aquatic life and conservation
Mayo Clinic in Arizona
2025
Kafrelsheikh University
2018-2021
Mayo Clinic
2015-2017
Midwest Orthopaedic Research Foundation
2017
Central Laboratory For Agricultural Expert Systems
2016
VA Nebraska Western Iowa Health Care System
2012-2015
University of Nebraska Medical Center
2008-2015
UnityPoint Health
2012
Creighton University
2001-2003
Abstract B lymphocytes play an essential regulatory role in the adaptive immune response through Ab production during infection. A less known function of is their ability to respond directly infectious Ags stimulation pattern recognition receptors expressed on surfaces. β-Glucans are carbohydrates present cell wall many pathogenic fungi that can be detected peripheral blood patients They have been shown participate innate inflammatory response, as they activate macrophages and dendritic...
B-cell activation is increasingly linked to numerous fibrotic lung diseases, and it well known that aggregates of lymphocytes form in the many these patients. Activation B-cells by pattern recognition receptors (PRRs) drives release inflammatory cytokines, chemokines, metalloproteases important pathophysiology pulmonary fibrosis. However, specific mechanisms patients with idiopathic fibrosis (IPF) are poorly understood. Herein, we have demonstrated microbial antigens contributes profibrotic...
The NLRP3 inflammasome is activated in response to different bacterial, viral and fungal pathogens serves as modulator of pattern recognition receptors signaling pathways. One the main functions participate IL-1beta maturation which important host defense against Pneumocystis other infections. However, dysregulation secretion are also implicated pathophysiology many auto-inflammatory disorders. Often time's inflammatory flares preceded by infectious illnesses questioning role infection...
Abstract PURPOSE: Monitoring disease progression in patients with high-grade gliomas (HGGs) is challenging due to treatment-related changes on imaging and the requirement for neurosurgical intervention obtain diagnostic tissue. DNA junctions HGGs often amplify oncogenes, making these fragments potentially more abundant blood than monoallelic mutations. Herein, we piloted a cell-free approach detection plasma of by leveraging patient-specific associated oncogene amplifications. EXPERIMENTAL...
Core 2 N-acetylglucosaminyltransferase 2/M (C2GnT-M) synthesizes all three β6GlcNAc branch structures found in secreted mucins. Loss of C2GnT-M leads to development colitis and colon cancer. Recently we have shown that targets the Golgi at Giantin site is recycled by binding non-muscle myosin IIA, a motor protein, via cytoplasmic tail (CT). But how this enzyme retained not known. Proteomics analysis identifies keratin type II cytoskeletal 1 (KRT1) as protein pulled down with anti-c-Myc...
The influence of herbicides causes health and economic loss, which requires innovative solutions to sustain the aquaculture industry. In this regard, dietary isatis is included in Nile tilapia diets relieve atrazine (ATZ)-induced growth retardation, hepato-renal dysfunction, oxidative stress. first second groups offered control diet (control), while third fourth supplemented (1%). Meantime, half water was replaced mixed with ATZ (1.39 mg/L) for 30 days. group fish delivered had significantly...
Sialyl Lewis antigens are selectin ligands involved in leukocyte trafficking and cancer metastasis. Biosynthesis of these occurs by the sequential actions several glycosyltransferases Golgi apparatus following synthesis protein backbone endoplasmic reticulum. In this study, we examine how sialyl a (sLe(a)) is regulated prostatic cells identify mucin that carries glycotope. We treat human including one normal three cancerous with histone deacetylase inhibitors, valproic acid, tricostatin A...
Abstract Metalloproteinases (MMPs) contribute to tissue remodeling and acute inflammation not only by degrading extracellular matrix proteins but also controlling the influx of chemokines through regulation shedding syndecans. B-lymphocytes, in addition their well-known function as antibody producing cells, participate innate immune response secreting inflammatory cytokines chemokines. However, there is little information about role B-lymphocytes MMPs; consequently, herein we investigated...
Thirty multiparous lactating Holstein cows with an average live body weight of 642 ± 21 kg and daily milk yield 30.46 0.59 were used in this study. Cows parities 2 4 following their peak period, divided into three groups, ten each group. The control group was fed yellow corn grain rations (YCG), while for the 2nd 3rd 25 50% YCG replaced dry sugar beet pulp (DSBP), denoted as DSBP25 DSBP50, respectively. contents matter, organic ether extract, nitrogen-free fiber carbohydrate experimental...
This study was conducted to evaluate the effect of replacing yellow corn (Zea maize) with sorghum (sorghum bicolor) on growth performance and body composition Nile Tilapia. Sorghum included into diets at four levels (25%,50%, 75% 100%). The zero level act as a control response fish fed containing additive Lacto cel-con supplementation (as probiotic) rate (0.3g/kg diet). All were isonitrogenous isoenergetic. results after 16 week experimental period indicated that onthe + probiotic (T3)...
This study aimed to investigate the effect of adding chelated zinc or/and manganese methionine on productive and postpartum reproductive traits. Twenty lactating Friesian cows with an average live body weight 500 kg 2-4 seasons lactation were used after calving immediately divided into four similar groups (5 each) assigned randomly treatments feeding trial. Cows fed a basal ration that consisted 40% concentrate feed mixture (CFM), fresh berseem (FB) 20% rice straw (RS), dry matter basis. The...