A5035062753- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
- Cancer Immunotherapy and Biomarkers
- Kidney Stones and Urolithiasis Treatments
- Lung Cancer Treatments and Mutations
- Neuroblastoma Research and Treatments
- Foreign Language Teaching Methods
- Advanced Biosensing Techniques and Applications
- Cancer Cells and Metastasis
- Iron Metabolism and Disorders
- MRI in cancer diagnosis
- Sexual Differentiation and Disorders
- Streptococcal Infections and Treatments
- Acute Kidney Injury Research
- Vitamin C and Antioxidants Research
- Sepsis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Balkan and Eastern European Studies
- Human Health and Disease
- Biomedical Research and Pathophysiology
- Nutrition, Genetics, and Disease
- Renal and Vascular Pathologies
University Hospital Centre Zagreb
2019-2024
Children's Hospital Srebrnjak
2023
e13080 Background: The combination of CDK4/6i and endocrine therapy (ET) is the standard care in first-line treatment hormone receptor positive (HR+), HER2- aBC. In registrational studies, progression-free survival (PFS) all three ranged from 23.8 to 28.12 months overall (OS) 53.9 66.8. Croatia, both ribociclib palbociclib were approved for clinical use August 2018 abemaciclib November 2019. Methods: This retrospective study included patients with endocrine-sensitive HR+, aBC treated...
Abstract Introduction Breast cancer (BC) is a disease characterized by significant intra- and intertumoral heterogeneity. Hence, it not surprising that new subtypes with distinct biological features are being discovered, even among previously well-defined BC groups. Recently, HER2-low emerged as entity specific clinical behavior, response to treatment prognosis. subset of HER2-negative BC, HER2 immunohistochemical (IHC) score 1+ or 2+, without gene amplification measured in situ...
Abstract BACKGROUND: According to immunohistochemistry (IHC) expression of HER2 receptor, breast cancer (BC) can be classified as either IHC score 0, 1+, 2+ or 3+. Until recently, two distinct BC subtypes were recognized depending on the and in situ hybridization (ISH) score: positive (IHC 3+ ISH-amplified) negative 1+ ISH negative). More recently a new entity termed HER2-low was acknowledged, defined ISH-negative. Given that no treatment benefit observed group patients pivotal trastuzumab...
Neratinib is approved based on the phase III ExteNET study in Europe since 2018 to treat adult patients with Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2-positive (HR+/HER2+) early-stage breast cancer (eBC) completing adjuvant trastuzumab-based therapy <1 year ago (EU label). A 2017 Early Access Program (EAP) granted neratinib access awaiting product availability. The eBC treatment landscape has evolved ExteNET, and there a need assess safety effectiveness recent...
Dual human epidermal growth factor receptor 2 (HER2) blockade with trastuzumab and pertuzumab combined taxane-based chemotherapy (Cht) has been the standard first-line treatment for HER2-positive metastatic breast cancer (mBC) years, due to impressive results of CLEOPATRA study. Real-world (RW) studies have become critical assessing effectiveness safety in real-life circumstances. The aim this study was analyze outcomes therapy mBC RW clinical practice, specifically focusing on use...
FIGURE 2. The apical four chamber view and Doppler aortic valve continuous wave after transcatheter implantation.Critical decompensated stenosis -a cascading approach to solving
e13078 Background: BC is the most common malignant disease and leading cancer-related cause of death in women. Despite significant achievements treatment, advanced (aBC) still an incurable disease. HR+/HER2- subtype accounts for 70% all BC. One mutations PIK3CA gene mutation which can induce endocrine chemo- resistance. In early BC, patients (pts) with mostly have better, but aBC worse prognosis. Standard first-line treatment a combination CDK4/6i therapy. status often assessed this group...
Od 2010. godine strukovno obrazovanje medicinskih sestara / tehničara prilagođeno je Direktivi Europske unije zbog čega uveden novi petogodišnji kurikulum. Kurikulum obuhvaća općeobrazovni dio (prve dvije srednje škole) te strukovni od trećeg do petog razreda u kojem najveći udio čine predmeti zdravstvene njege, odnosno sestrinske skrbi. Do 2021. izdani su udžbenici za sve obvezne strukovne predmete, a neke postoji mogućnost izbora između dvaju udžbenika. Cilj ovog rada bio učiniti analizu...
Abstract Background: Although huge progress has been made in treating HER2-positive metastatic breast cancer the last decade, it remains an incurable disease. Dual anti-HER2 therapy with pertuzumab and trastuzumab combined chemotherapy represents standard first line treatment of cancer, view impressive CLEOPATRA study results. The aim this was to analyze efficacy dual antiHER2 real-world clinical practice determine differences clinicopathological characteristics long-term responders...
Aim: To explore the protective role of hydration, urine alkalization (Na bicarbonate) and high doses antioxidant (N-acetylcysteine) in prevention CIN.Material methods: In a prospective, randomized, single-blinded study patients were divided into three groups: 1) peroral 2) Na bicarbonate infusion 3) N-acetylcysteine (NAC) plus NaHCO3 infusion.Serum creatinine (SCr), blood urea nitrogen (BUN), neutrophil gelatinase-associated lipocalin (NGAL) measured before 48 hours after angiography.Mehran...
Uvod: Smrtnost sepse je visoka usprkos antimikrobnim lijekovima, stoga se ispituju imunomodulatorni lijekovi, između ostalih i statini. Cilj: Pokazati imaju li bolesnici prethodno liječeni statinima lakši klinički oblik manju smrtnost sepse. Ustroj: Retrospektivno kohortno, opservacijsko istraživanje, usporedba liječenih neliječenih statinima. Ispitanici: Sepsa iz opće populacije, bakterijski izolat hemokultura, dob ≥ 50 god. Rezultati: Uključeno 899 bolesnika, 116 (12.9%) Bez statistički...
Usprkos znatnom napretku medicine smrtnost od sepse i danas je dalje izrazito visoka. Stoga se ulažu velika sredstva u potrazi za novim lijekovima koji modificiraju upalni odgovor domaćina. Nakon provedenih eksperimentalnih istraživanja znanstvenici su dokazali protuupalna, imunomodulatorna antikoagulacijska svojstva inhibitora 3-hidroksi-3-metil-glutaril koenzim A reduktaze, poznatijih pod nazivom statini, a trenutno koriste kontrolu hiperlipidemije smatraju korisnim prevenciji...
Uvod: Skrb za bolesne u Koprivnici svojim je začecima usko povezana s radom redovnica iz Družbe sestara milosrdnica sv. Vinka Paulskog. Prve školovane medicinske sestre na područje Koprivnice dolaze nakon otvaranja Školske poliklinike 1928. godine. Tako su razdoblju od do 1937. godine radile, uglavnom kraće vrijeme, Zlata Baldić, Štefanija Holjevac, Sofija Pavleković Stipetić i Marija Pavlović. Brozović Koprivnicu dolazi Pregledom pronađene dokumentacije željelo se dobiti uvid rad doprinos...