Porous organic polymers (POPs), a class of highly cross-linked, amorphous possessing micropores, have recently emerged as versatile platform for the deployment catalysts. These materials can be divided into three major classes: POPs that incorporate rigid well-defined homogeneous catalysts building blocks, modified post-synthesis, and encapsulate metal particles. This perspective article summarizes recent developments in POP-based catalysis outlines potential platforms heterogeneous along...

A new four-component domino reaction has been discovered. The is easy to perform simply by mixing four common reactants and K2CO3 in ethylene glycol under microwave irradiation. proceeds rapidly can be finished within 10−24 min with water as the major byproduct, making workup convenient. Four stereogenic centers one quaternary carbon−amino function are controlled very well; stereochemistry was unequivocally determined X-ray structural analysis. resulting pyrido[3,4-i]quinazoline derivatives...

A novel four-component domino reaction has been discovered. The is easy to perform simply by mixing four common reactants and Cs2CO3 in ethylene glycol under microwave heating. proceeds at fast rates can be finished within 15−24 min, which makes workup convenient. Four stereogenic centers with one quaternary carbon−amino function have controlled completely. stereochemistry unequivocally determined X-ray structural analysis. resulting tricyclo[6.2.2.01,6]dodecane derivatives are of importance...

The asymmetric catalytic Strecker reaction of achiral N-phosphonyl imines with Et2AlCN has been established. Both free amino alcohols and BINOLs have proven to be effective catalysts afford excellent enantioselectivities yields. group can readily cleaved under mild conditions enable purification crude products by simple washing hexane. N,N-dialkyl diamine auxiliary recovered quantitatively via n-BuOH extraction. scope for both was vastly studied this new system.

The new asymmetric catalytic Strecker reaction of achiral N-phosphonyl imines has been established. Excellent enantioselectivity (95.2-99.7% ee) and yields (89-97%) have achieved by using primary free natural amino acids as catalysts Et(2)AlCN nucleophile. This work also presents the novel use nonvolatile inexpensive in catalysis. protecting group enabled simple product purification to be simply washing crude products with hexane, which is defined GAP chemistry (GAP:...

A new multicomponent domino reaction for rapid and regioselective synthesis of highly functionalized benzo[h]pyrazolo[3,4-b]quinolines has been established. The can be conducted by using readily available inexpensive substrates under microwave irradiation within short periods 10-26 min. Good to excellent chemical yields (61-91%) complete regioselectivity have achieved 22 examples. Tedious work-up procedure avoided due the direct precipitation products from solution. resulting benzoquinolines...

Chiral N-phosphonyl imines were found to be efficient electrophiles for reaction with diethylaluminium cyanide, a non-volatile and inexpensive cyanide source. The produced chiral Strecker adducts, α-aminonitriles, in excellent chemical yields (94–98%) diastereoselectivities (95 : 5 >99%). This synthesis was confirmed follow the GAP chemistry (group-assistant-purification chemistry) process, which can avoid traditional chromatography recrystallization purifications, i.e., pure α-aminonitriles...

A variety of substituted chiral propargylamines have been synthesized by reacting N-phosphonylimines with lithium aryl/alkyl acetylides. Seventeen examples were studied to give excellent yields (>90%) and diastereoselectivities (96 : 4 99 1). It was found that the types bases for generating acetylides solvents are crucial effectiveness this asymmetric reaction. In addition, N,N-isopropyl group on N-phosphonylimine auxiliary proven be superior other protecting groups in controlling...

A series of chiral N ‐phosphonyl imines have been synthesized and utilized successfully in asymmetric aza‐Henry reaction. The auxiliary was optimized for this reaction by varying different R groups on the nitrogen atoms. is convenient to perform give excellent yields good diastereoselectivities. absolute stereochemistry unambiguously determined converting a resulting vicinal nitroamine into its ‐Boc derivative which serves as known compound.

Novel chiral N ‐phosphinamide and N‐ phosphinyl imines have been designed, synthesized applied to asymmetric aza‐Henry reaction give excellent chemical yields (92%– quant.) diastereoselectivity (91% >99% de ). The showed a great substrate scope in which aromatic/aliphatic aldehyde‐ ketone‐derived ‐phosphinyl can be employed as electrophiles. phosphinamide stored at room temperature for more than 2 months without inert gas protection, were also proven highly stable long period under...

In our current work, we have reported the first cobalt-catalyzed cross-coupling of arylboronic acid with alkyl/aryl phosphites under mild conditions. The reaction was carried out in presence zinc powder as an additive and ter-pyridine a ligand. use non-precious cobalt salt makes protocol advantageous, it is inexpensive more abundant than previously used methods where precious metal salts (Pd Pt) were used. has wide substrate scope products obtained good yields.

Chiral N ‐phosphonylimines were found to react with lithium phosphites provide various substituted chiral α‐amino phosphonates in excellent yields (94–97%) and diastereoselectivities (93:7–99:1). The types of bases utilized for generating the nucleophile are crucial effectiveness asymmetric induction. In addition, N,N ‐isopropyl group on ‐phosphonylimine auxilliary was proven be superior other protecting groups controlling diastereoselectivity. absolute configuration unambiguously determined...

3-Iodo allenoates were generated in situ and utilized, for the first time, ring opening of oxiranes a regioselective fashion. This simple one-pot three-component reaction protocol provides easy access to highly functionalized homoallylic alcohols good yields moderate very (Z/E) selectivity. The two functional groups (ester halogen) can be further subjected many synthetic transformations.

Abstract We have developed novel Manganese‐terpyridine ( Terpy ) and Terpy‐derivative systems for dehydrogenative coupling of amines alcohols in the presence air. A variety manganese salts were first screened effects temperature, extent catalytic loading, different terpyridine derivatives on efficiency reaction thoroughly studied. The resulting aldimines isolated moderate to high yields, exhibiting broad substrate scope reaction. yields obtained both electron‐donating electron‐withdrawing...

Benzimidazole has attracted a great deal of importance due to their interesting chemistry and wide utility. range uses applications is produced in quantities throughout the world. The current research work was aim evaluate vitro antifungal activity series benzimidazole derivatives. A derivatives were synthesized by reacting various amine o phenylene diame with carbon disulphide presence Potassium hydroxide. All bis characterized IR, 1H NMR chromatography method (TLC). antibacterial evaluated...

Mouth dissolving tablets (MDTs) has extended much attention as a preferred alternative to conventional oral dosage form. It provides an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing capsules. MDTs the unique property of rapidly disintegrating and/ or releasing drug soon they come contact with saliva, thus obviating requirement water during administration. The current review describes ideal characteristics, significance, limitations mainly...