A5090587496- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Global Maternal and Child Health
- Bacterial biofilms and quorum sensing
- Neonatal and Maternal Infections
- Vibrio bacteria research studies
- HIV/AIDS Research and Interventions
- Intraocular Surgery and Lenses
- Pediatric Urology and Nephrology Studies
- Tuberculosis Research and Epidemiology
- Vaccine Coverage and Hesitancy
- Ocular Infections and Treatments
- Escherichia coli research studies
- Hepatitis Viruses Studies and Epidemiology
- Adolescent Sexual and Reproductive Health
- Retinal and Optic Conditions
- Reproductive tract infections research
- Pelvic floor disorders treatments
- Nosocomial Infections in ICU
- Pharmaceutical and Antibiotic Environmental Impacts
- Salmonella and Campylobacter epidemiology
Catholic University of Health and Allied Sciences
2016-2025
Bugando Medical Centre
2016-2025
University of Calgary
2017-2021
Makerere University
2013-2019
Mbarara University of Science and Technology
2019
University of Bahrain
2010
Neonatal sepsis is a significant cause of morbidity and mortality in neonates. Appropriate clinical diagnosis empirical treatment given setting crucial as pathogens bacterial antibiotic sensitivity pattern can considerably vary different settings. This study was conducted at Bugando Medical Centre (BMC), Tanzania to determine the prevalence neonatal sepsis, predictors positive blood culture, deaths antimicrobial susceptibility, thus providing essential information formulate policy for...
Surgical site infections (SSIs) are difficult to treat and associated with substantially longer hospital stay, higher treatment cost, morbidity mortality, particularly when the etiological agent is multidrug-resistant (MDR). To address limited data in Uganda on SSIs, we present spectrum of bacteria isolated from hospitalized patients, magnitude impact MDR bacterial isolates among patients SSIs. A descriptive cross sectional study was conducted September 2011 through April 2012 involving 314...
Abstract Background Antimicrobial resistance (AMR) is a global health security threat and associated with increased morbidity mortality. One of the key drivers AMR inappropriate use antibiotics. A component improving antibiotic conducting antimicrobial (AMU) surveillance. Methods USAID Medicines Technologies Pharmaceutical Services Program has supported implementation stewardship activities, including setting up systems for AMU surveillance in Tanzania Uganda. Results from both countries...
Malaria, schistosomiasis and intestinal helminth infections are causes of high morbidity in most tropical parts the world. Even though these often co-exist, studies focus on individual diseases. In present study, we investigated prevalence Plasmodium falciparum-malaria, schistosomiasis, soil-transmitted infections, respective co-infections, among schoolchildren northwest Tanzania.A cross sectional study was conducted living villages located close to shores Lake Victoria. The Kato Katz...
The increased presence of extended-spectrum beta-lactamase (ESBL)-producing bacteria in humans, animals, and their surrounding environments is global concern. Currently there limited information on ESBL rural farming communities worldwide. We performed a cross-sectional study Mwanza, Tanzania, involving 600 companion domestic farm animals between August/September 2014. Rectal swab/cloaca specimens were processed to identify ESBL-producing Enterobacteriaceae. detected 130 (21.7%) carrying...
The study was conducted to establish predictors of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) neonatal sepsis and mortality in a tertiary hospital, Tanzania. Between July December 2016, blood culture performed neonates with clinical features neonates/mothers/guardians were screened for ESBL colonization. Selected isolates underwent whole genome sequencing investigate relatedness. Logistic regression analysis determine ESBL-PE associated mortality. Neonatal...
Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae commonly cause infections worldwide. BlaCTX-M-15 has been detected in hospital isolates Mwanza, Tanzania. Little is known regarding the faecal carriage of ESBL and blaCTX-M-15 allele among humans community developing countries. A cross-sectional study involving 334 from settings Mwanza City was conducted between June September 2014. Stool specimens were collected processed to detect producing enterobacteriaceae. confirmed...
Methicillin resistant
Objective To delineate the prevalence and factors associated with antimicrobial use across six referral hospitals in Tanzania using WHO point survey (PPS) methodology to inform hospital-specific stewardship programmes. Design Cross-sectional analytical study. Setting Six Tanzania. Participants Patients irrespective of age gender (n=948) admitted hospital wards before 8:00 hours on each day were included December 2019. Using PPS methodology, data hospitals, wards, patients, antibiotics,...
Abstract Background Endophthalmitis is a severe complication of cataract surgery which leads to high ocular morbidity and visual loss even with antibiotic treatment. Bacterial floras are the implicated causative agents. This study was undertaken evaluate external surface bacterial isolates their antimicrobial susceptibility patterns among pre-operative patients at Mulago National Hospital. Methods cross sectional enrolled consecutively 131 scheduled for routine in Department Ophthalmology...
Urinary tract infection (UTI) and preeclampsia are common among pregnant women associated with adverse maternal-fetal neonatal outcomes. Despite this, limited information exists on the association between UTIs in Tanzania to guide specific management thereby averting A 1:2 matched case-control study (by age gravidity) involving 131 (cases) 262 without (controls) was conducted. Sociodemographic clinical collected using a questionnaire. Midstream urine samples were during admission for culture...
Background The prevalence of Methicillin resistant Staphylococcus aureus (MRSA) is progressively increasing globally with significant regional variation. Understanding the lineages crucial in controlling nosocomial infections. Recent studies on S. Uganda have revealed an escalating burden MRSA. However, genotypes circulating among patients are not known. Here, we report surgical site infections (SSI) at Mulago National hospital, Kampala, Uganda. Methods A cross-sectional study involving 314...
Extended spectrum beta-lactamase producing bacteria (ESBL) are common causes of neonatal sepsis worldwide. Neonatal due to ESBL is associated with increased morbidity and mortality at Bugando Medical Centre (BMC). Due limited information on the sources these strains BMC, this study was conducted evaluate existence, magnitude transmission from post-delivery women neonates Mwanza-Tanzania. A cross-sectional obstetrics wards May July 2013, involving their neonates. Rectal swabs were collected...
Abstract Background Multidrug resistance (MDR) is a major clinical problem in tertiary hospitals Tanzania and jeopardizes the life of neonates critical care units (CCUs). To better understand methods for prevention MDR infections, this study aimed to determine, among other factors, role MDR-Gram-negative bacteria (GNB) contaminating neonatal cots hands mothers as possible transmission bacteremia at Bugando Medical Centre (BMC), Mwanza, Tanzania. Methods This cross-sectional, hospital-based...
Background: There is a growing body of evidence on the potential involvement coagulase-negative Staphylococci (CoNS) in causing urinary tract infections (UTIs). The aim this study was to delineate virulence potential, antimicrobial resistance genes, and sequence types CoNS isolated from patients with UTI symptoms pyuria Tanzania. Methods: more than 125 leucocytes/μL were retrieved, subcultured, whole-genome sequenced. Results: Out 65 isolates, 8 species identified; Staphylococcus...
Methicillin resistant Staphylococcus aureus (MRSA) nasal carriage is a potential niche for spread and risk factor subsequent infections. Despite the fact that medical students are exposed to patients in hospital during their training, information on S. MRSA among Tanzania remains be dearth so as guide appropriate infection control preventive measures.A cross-sectional study involving 314 students, pre-clinical (n = 166) clinical 148), at Catholic University of Health Allied Sciences (CUHAS)...
Blood stream infections (BSIs) cause a complex cascade of inflammatory events, resulting in significant morbidity and mortality children Tanzania. This study was designed to delineate circulating bacterial species, antimicrobial resistance (AMR) profiles risk factors for BSIs among the referral health care facilities so as guide comprehensive management.A multiple cross sectional analytical conducted between July 20, 2016 October 04, 2017 involving 950 less than five years age North-western...
Complications of indwelling urinary catheterization (IUC) are associated with significant morbidity and mortality, thus affecting patient's well-being. Understanding the magnitude factors complications is crucial in designing appropriate preventive strategies. A cross-sectional study was conducted at Bugando Medical Centre, involving patients long-term short-term IUC from December 2016 to September 2017. The data were analyzed by STATA 13.0. Catheter-associated tract infection (CA-UTI)...
Antimicrobial resistance (AMR) is a global health issue disproportionately affecting low- and middle-income countries. In Tanzania, multi-drug-resistant bacteria (MDR) are highly prevalent in clinical community settings, inhibiting effective treatment recovery from infection. The burden of AMR can be alleviated if antimicrobial stewardship (AMS) programs coordinated incorporate local knowledge systemic factors. AMS includes the education providers to optimise use improve patient outcomes...
Background: Antimicrobial stewardship (AMS) programs optimize use of antimicrobi-als and reduce antimicrobial resistance (AMR). This study evaluated implementation AMS in Africa using a harmonized regional approach. Methods: was an exploratory cross-sectional across five countries involving 32 hospitals adapted Periodic National Hospitals Assessment Tool WHO policy guidance on integrated activities human health. Results: found baseline scores for core elements ranging from 34% to 79%...
Purpose: The National Action Plan on antimicrobial resistance (NAP-AMR) in Tanzania is focused blood stream infections and urinary tract despite skin soft tissue (SSTIs) being common. This study assessed the proportion of laboratory-confirmed SSTIs, identify bacterial species involved, analyze AMR phenotypes, investigate risk factors associated with multidrug-resistant (MDR) SSTIs. Patients Methods: Analytical cross-sectional was conducted between January June 2023, involving 614 patients...
Background: Antimicrobial stewardship (AMS) programs optimize the use of antimicrobials and reduce antimicrobial resistance (AMR). This study evaluated implementation AMS in Africa using a harmonized regional approach. Methods: was an exploratory cross-sectional across five countries involving 32 hospitals adapted Periodic National Hospitals Assessment Tool from World Health Organization (WHO) policy guidance on integrated activities human health. Results: found baseline scores for core...
Abstract Background Increased antimicrobial use during the COVID-19 pandemic has driven resistance (AMR) globally, particularly in resource-limited settings. This study assessed AMR patterns urinary tract infections (UTIs) Uganda and Tanzania before pandemic. Methods A cross-sectional was conducted among UTI patients at healthcare facilities Mbarara (Uganda) Mwanza (Tanzania) between March 2019–September 2020 January–December 2021. Mid-stream urine samples were collected analysed following...
Introduction: Rotavirus infections frequently cause acute gastroenteritis in humans and are the most important of severe dehydrating diarrhea young children both developed developing countries. Methodology: This was a prospective cross-sectional, hospital-based study on 300 ≤ 5 years with watery who attended Bugando Medical Centre (BMC) Nyamagana District hospital between May November 2009. Stool specimens were tested for rotavirus infection using latex agglutination test. Data cleaned...