A5046726136- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Global Public Health Policies and Epidemiology
- Climate Change and Health Impacts
- Health and Lifestyle Studies
- High Altitude and Hypoxia
- Cardiac Imaging and Diagnostics
- Health disparities and outcomes
- Coronary Interventions and Diagnostics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Air Quality and Health Impacts
- Cardiac electrophysiology and arrhythmias
- Mechanical Circulatory Support Devices
- Healthcare Policy and Management
- Cardiac Ischemia and Reperfusion
- Primary Care and Health Outcomes
- Cardiac Structural Anomalies and Repair
- Heme Oxygenase-1 and Carbon Monoxide
- Insurance, Mortality, Demography, Risk Management
- Atrial Fibrillation Management and Outcomes
- Stress and Burnout Research
- Cardiac Valve Diseases and Treatments
- Frailty in Older Adults
University of Chile
2013-2025
Instituto de Salud Pública de Chile
2021-2022
Clinica Santa Maria
2006-2017
Universidad de Los Andes, Chile
2017
University of Miami
2017
University of Utah
2017
Sociedad de Biología de Chile
2004-2016
Hospital Barros Luco-Trudeau
2013
Pontificia Universidad Católica de Chile
2001-2004
Catholic University of America
2001
Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, improve myocardial remodeling function experimental models of cardiovascular disease. Although bone marrow-derived have been previously assessed for their therapeutic potential individuals with heart failure reduced ejection fraction, no clinical trial has evaluated intravenous infusion UC-MSCs these patients.Evaluate the safety efficacy UC-MSC patients chronic...
Abstract This cross-sectional ecological study described fruit and vegetable (F&V) intake variability across 144 cities in 8 Latin American countries by city-level contextual variables. Data sources came from health surveys census data (Argentina, Brazil, Chile, Colombia, El Salvador, Guatemala, Mexico, Peru). Self-reported frequency of F&V was harmonised surveys. Daily considered as consumption 7 d the week. Using a mixed-effects model, we estimated age sex-standardised city...
The impact of Chilean health reform in the management and mortality ST elevation myocardial infarction (STEMI) hospitals Background: In 2005 government started a care (AUGE) that guarantees medical treatment for acute infarction.Aim: To quantify AUGE on in-hospital STEMI group hospitals.Material methods: Three thousand five hundred forty six patients with from 10 perform thrombolysis as main reperfusion therapy were analyzed.We compared demographic clinical characteristics, hospital...
To evaluate the impact of a complete smoking ban in enclosed spaces on incidence acute myocardial infarction Chile.The population-based study involved residents urban areas, where 80% Chilean population live, aged 20 years or older who had infarction. Monthly and mortality rates at health-care facilities between January 2011 December 2014 were derived from admission databases. Regression discontinuity methods used to estimate near-immediate disease enforcing smoke-free legislation March...
Objective To evaluate the oxidative stress status and modification with glucose-insulin-potassium (GIK) therapy in patients acute myocardial infarction undergoing primary percutaneous transluminal coronary angioplasty. Design Prospective, randomized, double-blinded, placebo-controlled study. Setting Cardiac intensive care unit at university hospital. Patients Twenty were randomized to GIK solution (30% glucose water insulin 50 IU/L, KCl 40 mM) vs. placebo (normal saline) 1.5 mL/kg/hr for 24...
In 2005, Chile implemented a universal system of health guarantees (AUGE) aimed at improving equitable access to quality medical care for priority conditions, including acute myocardial infarction (MI). Objective To evaluate 1-year survival in MI patients before and after AUGE. Methods Retrospective cohorts with (with without ST segment elevation) discharged alive from six public hospitals between January 2001–June 2005 (pre-AUGE) July 2008–March 2009 (post-AUGE). Chilean national mortality...
Incidence and case fatality due to acute myocardial infarction in Chile
Background . Limited information exists on blood pressure (BP) control factors and adherence to antihypertensive drug therapy (Rx) in developing countries. Methods Cross-sectional study randomly selected 992 hypertensive patients under a Chilean national comprehensive Cardiovascular Health Program (CVHP). Association of education, income, diabetes, obesity, physical activity, psychosocial characteristics, smoking, alcohol abuse with BP were evaluated by multivariate logistic regression....
The characteristics of patients with acute myocardial infarction (MI) admitted to 37 Chilean hospitals (GEMI Registry Group), have been analyzed in the period 1993-1995 and 1997-1998.To report changes hospital mortality between these 2 periods, a particular emphasis on impact treatment.Between we collected information from 2,957 1997-1998 registered 1,981 MI. Analysis periods was adjusted by demographic variables, coronary risk factors, MI location, Killip class admission different...
Objective To evaluate the effects of glucose-insulin-potassium (GIK) therapy on infarct size and left ventricular function when used as an adjuvant to primary angioplasty. Design Prospective, randomized, double-blind, placebo-controlled study. Setting Cardiac intensive care unit at a university hospital. Patients Thirty-seven patients with acute myocardial infarction for whom angioplasty was indicated. Interventions Eligible were randomized by blinded pharmacist GIK solution (30% glucose in...
Universal health coverage and accomplishment of secondary prevention goals among patients with acute myocardial infarctionBackground: In 2005, infarction (AMI) was included in a universal plan (GES) to reduce inequity care optimize its diagnosis treatment.Aim: To evaluate the effect GES risk factor control therapeutic management AMI.Material Methods: A survey conducted 2008-2009 six public hospitals.Patients were identified from hospital based registry AMI evaluated one year later laboratory...
Consumption of illicit drugs (ID) has been associated with an increased risk acute myocardial infarction (AMI). There is limited national evidence about the impact substance use over clinical presentation, management and outcomes AMI patients.To describe prevalence ID consumption in patients within Chilean Registry Myocardial Infarction (GEMI), comparing characteristics, outcome according to status.We reviewed data from GEMI registry between 2001 2013, identifying 18,048 AMI. The sample was...
To describe the characteristics of mortality from ischemic heart disease in Chile and its trend over time, to identify factors associated with extra-hospital this pathology between 1997 2007.A time-series study was conducted using database Department Health Statistics Information for 2007. Of total 917,029 deaths reported period, those whose primary cause (ICD-10 codes I20-I25) were selected. Crude adjusted rates calculated by age sex order analyze trend. Mortality analyzed place death,...
Health inequalities are marked in Chile. To address this situation, a health reform was implemented 2005 that guarantees acute myocardial infarction (AMI) care for the entire population. We evaluated if changed AMI early and long-term survival rates by hospital provider (public/private) using longitudinal population-based study of patients ≥15 years with first Chile between 2002 2011. Time trends (within 28 days) (29–365 age were assessed. identified 59,557 patients: median 64 years; 68.9%...
Effect of educational level on the prognosis acute myocardial infarctionBackground: Socioeconomic status is associated with cardiovascular mortality.Aim: To evaluate effect level, patients infarction in Chile.Material and Methods: Cohort study 3,636 aged 63.1 ± 13.2 years, 27% women, hospitalized 16 centers participating Chilean Myocardial Infarction Registry (GEMI) between 2009 2012.Vital was obtained from National Mortality Database.Patients were divided, according to four groups, namely...
ResumenAntecedentes: Desde el año 2005, se ha implementado en nuestro país un conjunto de políticas públicas para permitir acceso universal al tratamiento trombolítico a los pacientes con infarto agudo del miocardio (IAM).Para evaluar sus resultados es importante establecer estándares locales las distintas opciones reperfusión.Objetivos: 1) Comparar la mortalidad precoz y alejada IAM sometidos angioplastía primaria (angioplastía) versus trombolisis, Chile.2) Establecer factores riesgo estos...