A5076790984- Synthesis and Biological Evaluation
- Synthesis and biological activity
- DNA Repair Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Phytochemical and Pharmacological Studies
- Nicotinic Acetylcholine Receptors Study
- Microtubule and mitosis dynamics
- Cholinesterase and Neurodegenerative Diseases
- Graphene and Nanomaterials Applications
- Genomics, phytochemicals, and oxidative stress
- Quinazolinone synthesis and applications
- Biochemical and biochemical processes
- Electrospun Nanofibers in Biomedical Applications
- CRISPR and Genetic Engineering
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Cancer-related Molecular Pathways
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Electrochemical sensors and biosensors
- Cyclopropane Reaction Mechanisms
- Synthesis and bioactivity of alkaloids
- Inflammatory mediators and NSAID effects
- Phytochemistry and Bioactive Compounds
- BRCA gene mutations in cancer
Qatar University
2015-2024
Virginia Commonwealth University
2003-2015
The University of Texas Southwestern Medical Center
2013
AstraZeneca (United Kingdom)
2013
King Faisal University
2010
Virginia Tech
1999-2008
Virginia Commonwealth University Medical Center
2004
Several reversible inhibitors selective for human monoamine oxidase B (MAO B) that do not inhibit MAO A have been described in the literature. The following compounds: 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene, and trans,trans-farnesol are shown to competitively human, horse, rat, mouse with K(i) values low micromolar range but without effect on either bovine or sheep A. In contrast, competitive inhibitor isatin binds all known similar affinities. Sequence alignments crystal...
Abstract Purpose: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer with a median survival only 12 to 15 months. Current standard treatment consists surgery followed by chemoradiation. The poor patients GBM due aggressive tumor invasiveness, an inability remove all tissue, and innate chemo- radioresistance. Ataxia–telangiectasia mutated (ATM) excellent target for radiosensitizing because its critical role in regulating DNA damage response p53, among other cellular...
To investigate double strand break (DSB) repair and signaling in human glioma cells, we stably transfected U87 (ATM(+), p53(+)) cells with a plasmid having single I-SceI site within an inactive green fluorescent protein (GFP) expression cassette, allowing for the detection of homologous recombination (HRR) by GFP expression. HRR nonhomologous end joining (NHEJ) were also determined PCR. DSB was first detected at 12 h postinfection adenovirus expressing reaching plateau levels between 24 48...
Abstract Being a developed and promising approach, nanotechnology has attracted lot of attention in biomedical pharmaceutical therapy applications. Among nanostructured materials, mesoporous silica nanoparticles (MSNs) are effectively used as nanocarriers for drug delivery systems. MSNs can be tailored-designed by different synthetic techniques. Their morphological characteristics dictate the type application such materials. Recently, polymer-based materials have been employed to...
Ionizing radiation (IR) triggers many signaling pathways primarily originating from either damaged DNA or non-nuclear sources such as growth factor receptors. Thus, to study the damage-induced component alone by irradiation would be a challenge. To generate double-strand breaks (DSBs) and minimize signaling, human cancer cells having bromodeoxyuridine (BrdU) - substituted were treated with photosensitizer Hoechst 33258 followed long wavelength UV (UV-A) treatment (BrdU photolysis). BrdU...
The present study describes the synthesis of a series 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. showed varied selectivity against two isoforms. IC50 values found to be in micromolar submicromolar range. Ki compound 16 determined 0.047 0.020 μM for inhibition MAO-B, respectively. Dialysis enzyme-inhibitor mixtures indicated reversible competitive mode inhibition. Most synthesized analogs better toward MAO-B. However, introducing...
Recent positron emission tomography imaging studies have demonstrated a significant decrease in both monoamine oxidase A and B (MAO-A MAO-B) activities the brains of smokers. Normal levels activity are observed former smokers, suggesting presence one or more compounds tobacco smoke that may inhibit these enzymes. In this paper, we report results efforts to identify present flue-cured leaves MAO. The isolation procedure was guided by estimating inhibitory properties leaf extracts on liver...
Elaeagnus angustifolia (EA) is used as an alternative medicine in the Middle East to manage numerous human diseases. We recently reported that EA flower extract inhibits cell proliferation and invasion of oral HER2-positive breast cancer cells. Nevertheless, outcome on triple-negative (TNBC) cells has not been explored yet. herein investigate effect aqueous (100 200 μl/ml) two TNBC lines (MDA-MB-231 MDA-MB-436) for 48 h explore its underlying molecular pathways. Our data revealed suppresses...
// Jason M. Beckta 1, 2, * , Seth Dever Nisha Gnawali 1 Ashraf Khalil Amrita Sule 2 Sarah E. Golding Elizabeth Rosenberg Aarthi Narayanan 3 Kylene Kehn-Hall Bo Xu 4 Lawrence F. Povirk 5 Kristoffer Valerie 6 Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298, USA Biochemistry and Molecular Biology, National Center for Biodefense Infectious Diseases, George Mason Manassas, 20110, Cancer Research Department, Southern Institute, Birmingham, AL 35205,...
Endoplasmic reticulum (ER) is the key organelle involved in protein folding and maturation. Emerging studies implicate role of ER stress development chronic kidney disease. Thus, there an urgent need for compounds that could ameliorate prevent CKD. Piperine its analogs have been reported to exhibit multiple pharmacological activities; however, their efficacy against cells has not studied yet. Hence, goal this study was synthesize amide-substituted piperine screen them activity relieve using...
In colorectal cancer (CRC), aberrations in
Implementation of carbon nanofibers (CNFs) in biomedical applications have successful outcomes, however, they are still considered as a potential hazard. We herein used avian embryos at 3 days and its chorioallantoic membrane (CAM) 6 incubation to evaluate the impact synthesized CNFs on early stage embryogenesis angiogenesis. Our data point out that 50 μg/embryo concentration provoke adverse effects 75% CNFs-exposed die within 1-5 after exposure compared with their matched controls....
The aim of this study is to explore the outcome Teucrium polium (TP) medicinal plant consumption on early stage fetal development. We used chicken embryo at 3 days incubation as a model evaluate effect TP extract during embryogenesis. In addition, quantitative polymerase chain reaction (qPCR) was applied expression six genes related cell proliferation, apoptosis, sur-vival, angiogenesis, and migration. Our data revealed that exposure inhibits angiogenesis its chorioallantoic membrane. we...
Abstract As part of our ongoing research effort to develop new antimitotic agents based on the recently reported pyrimido[4,5‐ c ]quinoline‐1(2 H )‐one ring skeleton, we were interested in identifying structural elements that contribute cytotoxicity this class compounds. The effect several quinoline‐ring substituents was examined and compounds evaluated vitro for against three human cancer cell lines namely, lung fibrosarcoma HT‐1080, colon adenocarcinoma HT‐29, breast carcinoma MDA‐MB‐231....