A5086423611- Ovarian cancer diagnosis and treatment
- Virus-based gene therapy research
- interferon and immune responses
- Plant Gene Expression Analysis
- DNA Repair Mechanisms
- Immunotherapy and Immune Responses
- PARP inhibition in cancer therapy
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Polyomavirus and related diseases
- Animal Genetics and Reproduction
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Fibroblast Growth Factor Research
National University of Sciences and Technology
2014-2025
Centro de Biología Molecular Severo Ochoa
2024
Universidad Autónoma de Madrid
2024
Health First
2024
Edinburgh Cancer Research
2018-2020
Institute of Genetics and Cancer
2020
High grade serous ovarian cancer (HGSOC) is a major cause of female mortality. The approval poly (ADP-ribose) polymerase (PARP) inhibitors for clinical use has greatly improved treatment options patients with homologous recombination repair (HRR)-deficient HGSOC, although the development PARP inhibitor resistance in some revealing limitations to outcome. A proportion HRR-proficient cancers also benefit from therapy. Our aim compare mechanisms olaparib these two main molecular categories...
Mouse mammary tumor virus (MMTV) is a well-known cause of tumors in mice transmitted as endogenous proviruses or exogenously infectious virions. The hypothesis that retrovirus homologous to MMTV involved human breast cancers has resulted renewed interest the etiology cancer. Therefore, detection MMTV-like exogenous sequences 30-40 % invasive cancer increased attention towards this hypothesis. To detect prevalence Pakistani population, 666-bp-long envelop and 630-bp LTR were amplified from...
SUMMARY Rhythmic oscillation of biological processes helps organisms adapt their physiological responses to the most appropriate time day. Chromatin remodeling has been described as one molecular mechanisms controlling these oscillations. The importance changes in transcriptional activation well maintenance heterochromatic regions widely demonstrated. However, little is still known on how diurnal can impact global status chromatin modifications and, hence, control gene expression. In plants,...
Background: Bladder cancer is the 9th most prevalent malignancy worldwide. Fibroblast Growth Factor Receptor 3b (FGFR3b), involved in cell proliferation, differentiation, and migration, a mutations hotspot for bladder with aberration being S249C. Objective: Impact of S249C FGFR3b on tumorigenesis via immediate downstream adapter proteins, Substrate (FRS2 FRS3) analyzed computationally. Methods: Wildtype monomer was modeled using I-TASSER Phyre2. Whereas, mutation introduced DynaMut....
Introduction Constitutive expression of interferons (IFNs) and their downstream signalling pathways play a critical role in host responses to cell transformation the tumour microenvironment. Induction IFNs initiates transcription variety genes, so called IFN- stimulated genes (ISGs). Although ISGs is classically associated with suppression, subset defined as IRDS (Interferon - Related DNA- Damage Resistance Signature), elevated response endogenous IFN, self-DNA RNA exposure microenvironment...