A5018871372- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- Advanced Sensor and Energy Harvesting Materials
- Electrohydrodynamics and Fluid Dynamics
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Graphene and Nanomaterials Applications
- Surface Modification and Superhydrophobicity
- Additive Manufacturing and 3D Printing Technologies
- Natural Fiber Reinforced Composites
- Material Properties and Applications
- Nanocluster Synthesis and Applications
- Aerosol Filtration and Electrostatic Precipitation
- Polymer Nanocomposites and Properties
- Advanced Drug Delivery Systems
- Inorganic Chemistry and Materials
- Lignin and Wood Chemistry
- Polymer Nanocomposite Synthesis and Irradiation
- Conducting polymers and applications
- Additive Manufacturing Materials and Processes
- Advanced Materials and Mechanics
- Fluid Dynamics and Heat Transfer
- Particle Dynamics in Fluid Flows
Technical University of Liberec
2015-2024
Czech Technical University in Prague
2012
Clemson University
2010
The history of electrospinning is briefly introduced at the beginning article. fundaments process are then analysed physically to be translated into a successful technology. Self-organisation fluid in perceived as consequence various instabilities, based on electrohydrodynamics and, thus, highlighted key factor, theorising subject successfully elevate it highly productive technology manufacture nano-scale materials. main physical principle self-organisation appearance unstable tiny capillary...
Nanofibrous materials are essential components for a wide range of applications, particularly in the fields medicine and material engineering. These include protective materials, sensors, cosmetics, hygiene, filtration energy storage. The most widely used researched technology these is electrospinning. This method producing fibers yields highly promising results thanks to its versatility simplicity. Electrospinning employed multiple forms, among which needle needleless direct current (DC)...
Abstract Objectives We prepared 3D poly (ε‐caprolactone) ( PCL ) nanofibre scaffolds and tested their use for seeding, proliferation, differentiation migration of mesenchymal stem cell MSC s). Materials methods nanofibres were using a special collector common electrospinning; simultaneously, 2D layer was classic plain collector. Both seeded with s biologically tested. adhesion, migration, proliferation osteogenic investigated. Results The scaffold characterized by having better biomechanical...
Abstract Nanotechnologies allow the production of yarns containing nanofibres for use in composites, membranes and biomedical materials. Composite with a conventional thread core mechanical strength nanofibrous envelope functionality, e.g. biological, catalytic, have many advantages. Until now, such has been technologically difficult. Here, we show an approach to composite yarn whereby plume nanofibers generated by high throughput AC needleless collectorless electrospinning is wound around...
Traditional wound dressings have not been able to satisfy the needs of regenerative medicine biomedical area. With aim improving tissue regeneration, nanofiber-based fabricated by electrospinning (ES) processes emerged as a powerful approach. Nowadays, bioactive are mainly developed with combination natural and synthetic polymers, such polycaprolactone (PCL) chitosan (CHI). Accordingly, herein, PCL/CHI nanofibers varying PCL:CHI weight ratios (9:1, 8:2 7:3) or CHI viscosities (20, 100 600...
We describe a method of fabrication nanoporous flexible probes which work as artificial proboscises. The challenge making with fast absorption rates and good retention capacity was addressed theoretically experimentally. This shows that the probe should possess two levels pore hierarchy: nanopores are needed to enhance capillary action micrometer pores required speed up fluid transport. model controlled verified in experiments. also demonstrated proboscises can be remotely by electric or...
Transparent yet photoluminescent, materials with facile processability are key in many applications.
A large number of patients suffer from vascular diseases, resulting in the need for bypass surgery. Since there are still limitations replacement small diameter grafts, and demand developing more desirable grafts is increasing day by day. In this study, polycaprolactone small-diameter (6 mm) were produced successfully using custom-designed electrospinning apparatus. Radial fiber orientation was achieved rotational speed collector. The morphological, structural, mechanical, biological...
Tissue engineering scaffolds have been dedicated to regenerating damaged tissue by serving as host biomaterials for cell adhesion, growth, differentiation, and proliferation develop new tissue. In this work, the design fabrication of a biodegradable bilayer scaffold consisting ternary PLLA/PCL/CAB blend film layer PLGA/curcumin (CC) electrospun fiber were studied discussed in terms surface morphology, tensile mechanical properties, molecular interactions. Three different compositions...
Abstract Active wound dressings are attracting extensive attention in soft tissue repair and regeneration, including bacteria-infected skin healing. As the wide use of antibiotics leads to drug resistance we present here a new concept based on polycaprolactone nanofiber scaffold (NANO) releasing second generation lipophosphonoxin (LPPO) as antibacterial agent. Firstly, demonstrated vitro that LPPO released from NANO exerted activity while not impairing proliferation/differentiation...
Abstract A chronic nonhealing wound poses a significant risk for infection and subsequent health complications, potentially endangering the patient‘s well-being. Therefore, effective dressings must meet several crucial criteria, including: (1) eliminating bacterial pathogen growth within wound, (2) forming barrier against airborne microbes, (3) promoting cell proliferation, (4) facilitating tissue repair. In this study, we synthesized 8 ± 3 nm Ag NP with maleic acid incorporated them into an...
The study involved the electrospinning of copolymer poly(L-lactide-co-ε-caprolactone) (PLCL) into tubular grafts. subsequent material characterization, including micro-computed tomography analysis, revealed a level porosity around 70%, with pore sizes 9.34 ± 0.19 μm and fiber diameters 5.58 0.10 μm. Unlike fibrous polycaprolactone, electrospun PLCL promoted fibroblast endothelial cell adhesion proliferation in vitro. Moreover, regeneration vessel wall was detected following implantation and,...
The study focuses on a comparison of the electrospinning various polylactide and polycaprolactone (PLCL) copolymers poly-L-lactide (PLLA) (PCL) homopolymers. chemical characterisation, electrospinnability, fibrous morphology, degradation rate interactions with fibroblasts were assessed respect to homopolymers both lower (around 50,000) higher 95,000) molecular weights. research investigated commercially available as well synthesised copolymers. results revealed that electrospinnability...
Nanofibrous materials have great potential for use in tissue engineering due to their structure, which mimics the extracellular fibrous matrix.Increasing biological activity is currently main goal development of these scaffolds.From standpoint promoting healing and regeneration, human platelets containing hundreds biologically active molecules promising.The present work deals with preparation PVA-based nanofibrous material native platelet-derived proteins that are released a sustained...
We have prepared a candidate biocompatible construct for skin wound healing based on electrospun polycaprolactone (PCL) nanofibrous membranes. The membrane material was loaded either with L-arginine or alaptide, mixture of both bioactive components. Alaptide is spirocyclic synthetic dipeptide, an analogue melanocyte-stimulating hormone release-inhibiting factor. amino acid basic guanidine side chain. It direct precursor nitric oxide, which plays pivotal role in repair. presence and the...
Polymer-metal based material with unique 3D structure is an attractive substrate for the development of biomedical applications. A novel preparation composite from polymer fibres and silver nanoparticles has been designed through: (1) by phytosynthesis (2) incorporation these in a fibrous membrane prepared electrospinning. The nanoparticle biosynthesis was performed pure environmental-friendly, easy, static, bottom-up vitro regime using Tilia sp. leachate. TEM XRD depict formation,...
Abstract Orodispersible films comprise a promising dosage form with wide range of advantages compared to conventional formulations. The electrospinning process can significantly enhance the relevant characteristics orodispersible films, e.g., dissolution rate and ease administration. This study involved use two types hydroxypropyl methylcelluloses low molecular weight obtained from three different manufacturers as matrix. SEM, FTIR, RAMAN, DSC analyses revealed comparable values for all...
The development of an ideal vascular prosthesis represents important challenge in terms the treatment cardiovascular diseases with respect to which new materials are being considered that have produced promising results following testing animal models. This study focuses on nanofibrous polycaprolactone-based grafts assessed by means histological techniques 10 days and 6 months suturing as a replacement for rat aorta. A novel stereological approach assessment cellular distribution within...
The purpose of this work is to explore the preparation nanofibrous orally dispersible films (ODFs) by needleless electrospinning from active pharmaceutical ingredient (API) Tadalafil using particles suspended in a solution polymers and other excipients. prepared were characterized combination scanning electron microscopy, mechanical tests, measurements disintegration time dissolution characteristic, X-ray diffraction, differential calorimetry. Furthermore, we investigated impact lamination...