A5018424653- Immune Cell Function and Interaction
- Hemoglobin structure and function
- Acute Myeloid Leukemia Research
- S100 Proteins and Annexins
- Retinoids in leukemia and cellular processes
- Single-cell and spatial transcriptomics
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Mesenchymal stem cell research
- CAR-T cell therapy research
- Zebrafish Biomedical Research Applications
University of York
2024
University of Bristol
2020-2023
PD-1 signaling suppresses tumor-infiltrating lymphocytes by destabilizing their interactions with target tumor cells.
ABSTRACT Previous clinical studies and work in mouse models have indicated that platelets microclots might enable the recruitment of immune cells to pre-metastatic cancer niche, leading efficacious extravasation through vessel wall. Here, we investigated interaction between platelets, endothelial cells, inflammatory engrafted human zebrafish by live-imaging translucent larvae, show how clotting (and clot resolution) act as foci triggers for extravasation. Fluorescent tagging each lineage...