A5022048300- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Barrier Structure and Function Studies
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
Northeastern University
2020
Universidad del Noreste
2020
There remains a need for new drug targets treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury. Previous studies in mice reported that the antagonist JNJ-47965567 suppressed spontaneous seizures intraamygdala kainic acid model of epilepsy and reduced attendant gliosis hippocampus. drug-resistance profile this is not fully characterised, however, newer antagonists with superior pharmacokinetic profiles have recently...
Abstract Background This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance to evaluate the permeability of blood–brain barrier in rat model type 2 diabetes with presumption that small vessel disease contributing factor neuropathology diabetes. Methods The BBZDR/Wor rat, diabetes, and age-matched controls were studied for changes permeability. QUTE-CE, vascular biomarker, generated angiographic images...
Abstract Background This is an exploratory study using multimodal magnetic resonance imaging (MRI) to interrogate the brain of rats with type 2 diabetes (T2DM) as compared controls. It was hypothesized there would be changes in structure and function that reflected human disorder, thus providing a model system by which follow disease progression noninvasive MRI. Methods The transgenic BBZDR/Wor rat, animal T2MD, age‐matched controls were studied for voxel‐based morphometry, alteration white...
Abstract Objectives This is an exploratory study using multimodal magnetic resonance imaging (MRI) to interrogate the brain of rats with type 2 diabetes (T2DM) as compared controls. It was assumed there would be changes in structure and function that reflected human disorder, thus providing a model system by which follow disease progression non-invasive MRI. Methods The transgenic BBZDR/Wor rat, animal T2MD, age-matched controls were studied for voxel-based morphometry, alteration white gray...
Abstract Background This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance to evaluate the permeability of blood brain barrier in rat model type 2 diabetes with presumption that small vessel disease contributing factor neuropathology diabetes. Methods The BBZDR/Wor rat, diabetes, and age-matched controls were studied for changes permeability. QUTE-CE, vascular biomarker, generated angiographic images...
Abstract Background: This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance to evaluate the permeability of blood brain barrier in rat model type 2 diabetes with presumption that small vessel disease contributing factor neuropathology diabetes. Methods: The BBZDR/Wor rat, diabetes, and age-matched controls were studied for changes permeability. QUTE-CE, vascular biomarker, generated angiographic images...
Abstract Background: This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance to evaluate the permeability of blood-brain barrier in rat model type 2 diabetes with presumption that small vessel disease contributing factor neuropathology diabetes. Methods: The BBZDR/Wor rat, diabetes, and age-matched controls were studied for changes permeability. QUTE-CE, vascular biomarker, generated angiographic images...