A5035441417- Marine Bivalve and Aquaculture Studies
- Marine and fisheries research
- Adenosine and Purinergic Signaling
- Aquaculture Nutrition and Growth
- Diet and metabolism studies
- Environmental Toxicology and Ecotoxicology
- Proteoglycans and glycosaminoglycans research
- Neonatal and Maternal Infections
- Tuberculosis Research and Epidemiology
- Autoimmune Neurological Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Cellular Mechanics and Interactions
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Medical Imaging Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Mercury impact and mitigation studies
- Ferroptosis and cancer prognosis
- Aging, Health, and Disability
- Amino Acid Enzymes and Metabolism
- Fire effects on ecosystems
- Respiratory viral infections research
- Cell Image Analysis Techniques
- Mycobacterium research and diagnosis
- Peroxisome Proliferator-Activated Receptors
CIC biomaGUNE
2021-2025
Andalusian Institute of Agricultural and Fisheries Research and Training
2011-2022
Centro Tecnológico del Agua
2019-2022
Hospital Universitario La Paz
2015
Gobierno del Principado de Asturias
2013
University of Pinar del Río
2011
University of Havana
2011
Consejería de Agricultura, Pesca, Agua y Desarrollo Rural
2011
Universidad de León
2007
Universidad de La Rioja
2005
Abstract The increased frequency of harmful algal blooms (HABs) is a major environmental concern worldwide, resulting not only in treatment costs for drinking water but also impacts on tourism, commercial fishing and aquaculture risks to human animal health. Traditional strategies with ship-based approaches based field sampling laboratory analysis have been adopted assess HABs. However, these methods are labour intensive costly do provide synoptic views the bloom conditions. Here, we show...
There remains a need for new drug targets treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury. Previous studies in mice reported that the antagonist JNJ-47965567 suppressed spontaneous seizures intraamygdala kainic acid model of epilepsy and reduced attendant gliosis hippocampus. drug-resistance profile this is not fully characterised, however, newer antagonists with superior pharmacokinetic profiles have recently...
Introduction Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease resulting from repeated mild brain injuries (rmTBI). The necessity for diagnosis of CTE, which can so far only be confirmed after post-mortem, pressing need. New approaches to early diagnose this are crucial facilitate the translation novel treatment strategies clinic. Several studies have found suitable candidate biomarkers, but results not straightforward. As biological sex suggested major...
Enveloped viruses enter cells by binding to receptors present on host cell membranes, which trigger internalization and membrane fusion. For many viruses, this either directly or indirectly involves interaction with membrane-anchored carbohydrates, such as heparan sulfate, providing a potential target for broad-spectrum antiviral approach. Based hypothesis, we screened library of functionalized chitosan sulfates that mimic sulfate in cellular membranes inhibition SARS-CoV-2 respiratory...
Ruminant infection by Mycobacterium avium subsp. paratuberculosis (MAP) causes a granulomatous inflammatory response in the intestine and associated lymph nodes. Differences either affected organs or infiltrate were observed between species individuals. Such differences are usually attributed to variations host immune responses inconsistent effects among different MAP strains. To evaluate if strains induce immuno-pathological lambs, 28 one-month-old individuals divided into six groups...
The cofilin pathway plays a central role in the regulation of actin polymerization and formation cell membrane protrusions that are essential for migration. Overexpression has been linked to aggressiveness variety different cancers. In these cancers, phosphorylation at Ser3 is key regulatory mechanism modulating activity. activation status directly tumor invasion. Accordingly, this study, we examined expression its astrocytoma lines astrocytic tumors. We show was increased correlated with...
Purpose:The increase in butyrylcholinesterase (BChE) activity the brain of Alzheimer disease (AD) patients and animal models AD position this enzyme as a potential biomarker disease.However, information on ability BChE to serve is contradicting, also due scarce longitudinal studies abundance.Here, we report 11 C-labeling, vivo stability, biodistribution, study abundance brains control 5xFAD (AD model) animals, using potent selective inhibitor, [ C]4, positron emission tomography (PET)...
The P2X7 receptor (P2X7R) is an important contributor to neuroinflammation, responding extracellularly released adenosine triphosphate. Expression of the P2X7R increased in brain experimental and human epilepsy, genetic or pharmacologic targeting can reduce seizure frequency severity preclinical models. Experimentally induced seizures also increase levels blood. Here, we tested 18 F-JNJ-64413739, a positron emission tomography (PET) antagonist, as potential noninvasive biomarker...
This paper describes the lipid composition of commercial bivalve Donax trunculus and differences originated when animals were fed with two phytoplankton species (Tetraselmis suecica Chaetoceros sp.) in a hatchery. We also analysed sex-related classes fatty acid profile. Total lipids higher females than males. Triglycerides phospholipids major components, former dominated latter The main acids both sexes 16:0, 20:5n-3 (eicosapentaenoic acid) 22:6n-3 (docosahexaenoic acid). Females showed...
The increase of aquaculture production is associated with a growing interest in improving physiological status and welfare fish. For this reason, the search for strategies mitigating stress has been intensified, one these being food supplementation different amino acids (AA). objective study was to evaluate effects dietary phenylalanine (Phe) tyrosine (Tyr) supplements on endocrine state seabreams (Sparus aurata) subjected chronic stress. fish were stocked at 30 fish/tank recirculation...
In this study, the influence of food availability on gonadal development smooth clam Callista chione was analyzed for first time. adults were maintained 60 days under controlled conditions with two different diet rations: a scarce (3% dry weight algae by meat per day) and high (6%). The condition index, stage, oocyte size measured throughout experiment. Maturation gonad achieved in both groups. Nevertheless, index diameter significantly less scarce-diet group. These low values seem to be...
Abstract Donax trunculus is a much‐appreciated commercial clam whose natural populations have been overexploited in southern–western Spain during the last decades. In order to control decrease of beds, local governments establish annual closed seasons based on socioeconomic reasons, such as economic necessity or tourism interest. The objective this study was develop an efficient tool for predicting gonadal stages environmental condition data. This will allow improvement fishery management...
<title>Abstract</title> Enveloped viruses enter cells by binding to receptors present on host cell membranes, which trigger internalization and membrane fusion. For many viruses, this either directly or indirectly involves interaction with membrane-anchored carbohydrates, such as heparan sulfate, providing a potential target for broad-spectrum antiviral approach. Based hypothesis, we screened library of functionalized chitosan sulfates that mimic sulfate in cellular membranes inhibition...
Purpose: Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences traumatic brain injury (TBI). However, to date there are no pharmacological approaches predict or prevent development PTE. The P2X7 receptor (P2X7R) a cationic ATP-dependent membrane channel that expressed throughout brain. While increasing evidence suggests role for P2X7R during seizures and epilepsy, it unclear if changes in expression can TBI-induced development, whether antagonism protect...
Metal concentrations were measured in seawater the Piedras River estuary (southwest Spain) for 15 mo during 2005 to 2006. A significant sinusoidal seasonal variation of Cu and Zn was observed. The levels up 30 µg/L. Effects concentrations, ranging from 0–100 µg/L, exposure times 48 h, 72 96 h on both mortality a lethal concentration (LC50) Venerupis decussata (Linnaeus 1758) larvae studied. Larval 100% after 100 µg Cu/L, mobility decreased Cu/L or longer. Lethal set at 190, 97, 49...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)